Pharmacology of the Skin II
Pharmacology of the Skin II

Author:

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 602

ISBN-13: 3642740545

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The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.

Advances in Molecular Toxicology
Advances in Molecular Toxicology

Author: Claude Reiss

Publisher: VSP

Published: 1998-02

Total Pages: 590

ISBN-13: 9789067642781

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Molecular toxicology is on the way to setting a new standard in toxic risk assessment, with the powerful help of concepts and methods developed in the fields of molecular and cellular biology. The methods of molecular toxicology are endowed with qualities not always secured in more traditional approaches to toxicity assessment. These methods are easily standardized, reliable, reproducible and require only tiny amounts of the xenobiotic. They are much simpler, faster and less costly than current tests on animals and can be implemented with modest laboratory resources. This volume of Advances in Molecular Toxicology represents a collection of invited papers presented at the First European Workshop on Molecular Toxicology in Sophia Antipolis, France, The book covers 8 selected topics in molecular toxicology. The first two are devoted to ''physics'', dealing respectively with advanced instrumentation enabling location and quantification of xenobiotics in cells and organs with ultimate precision, and computer-assisted assessment of risk (QSAR). A comprehensive and up-to-date survey of molecular toxicology in the pharmaceutical industry is contributed by a pioneer in this field. The third section addresses the effect of xenobiotics on cell-cycle actors. Sections 4--6 deal with molecular toxicology in skin, kidney, nerve, liver and pancreatic cells. The last two sections describe methods to probe DNA damage and repair, and immunotoxicity.

Comprehensive Dermatologic Drug Therapy
Comprehensive Dermatologic Drug Therapy

Author: Stephen E Wolverton, MD

Publisher: Elsevier Health Sciences

Published: 2012-11-16

Total Pages: 1015

ISBN-13: 143772003X

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Safely and effectively treat a full range of skin disorders with Comprehensive Dermatologic Drug Therapy, 3rd Edition! This trusted dermatology reference provides concise, complete, up-to-date guidance on today's full spectrum of topical, intralesional, and systemic drugs. Dr. Steven E. Wolverton and a team of leading international experts clearly explain what drugs to use, when to use them, and what to watch out for. Prescribe with confidence thanks to quick-access summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Assess your knowledge and prepare for certification or recertification with more than 800 review questions and answers throughout the book. Contain costs and meet patient expectations with purchase information provided for major drugs. Quickly evaluate drug options for each disease discussed using a highly detailed, disease-specific index. Discover the best uses for new biologic therapeutics such as ustekinumab and rituximab, as well as newly improved TNF inhibitors. Offer your patients the very latest in cosmetic procedures, including chemical peels, intradermal fillers, and botulinum toxin. Use the safest and most effective drugs possible with new chapters on irritants and allergens in topical therapeutic agents, plus a new, separate chapter on mycophenolate mofetil. Review drugs recently taken off the market by the FDA, and use that knowledge to improve your current dermatologic drug therapy. Access the complete contents online at www.expertconsult.com and perform rapid searches for drug indications, interactions, monitoring guidelines, and much more.

Comprehensive Dermatologic Drug Therapy
Comprehensive Dermatologic Drug Therapy

Author: Stephen E. Wolverton

Publisher: Elsevier Health Sciences

Published: 2007-03-08

Total Pages: 2451

ISBN-13: 1437720706

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Safely and effectively prescribe today's full spectrum of topical, intralesional, and systemic drugs for dermatologic disorders! Dr. Steven E. Wolverton and a team of leading international experts explain what drugs to use, when to use them...and what to watch out for. Handheld software - included with the book - provides full-text explanations as well as at-a-glance summaries of key pharmacologic information, instantly accessible wherever and whenever questions about skin pharmaceuticals arise. Provides at-a-glance access to key information including summaries of indications/contraindications, dosage guidelines, drug interactions, drug monitoring guidelines, adverse effects, and treatment protocols. Features a consistent organization throughout to expedite fast reference. Provides purchase information for major drugs, to help you and your patients. Includes a highly detailed, disease-specific index, helping you to evaluate drug options for each disease discussed. .Highlights key controversies and provides expert guidance in a Question and Answer feature. Presents new chapters on TNF Inhibitors, Signal II Cytokine Inhibitors, Pimicrolimus, IV Immunoglobulin, Drug-Induced Malignancies, Polymorphisms, and non-dermatologic drugs related to dermatologic problems. Features updates on new drug findings and new research, especially findings on predicting an individual response to drugs on the basis of ethnicity and gender.