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Publisher: Academic Press
Published: 2011-07-13
Total Pages: 558
ISBN-13: 0123855330
DOWNLOAD EBOOKThis is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. - Authors are the leading authorities in their fields - Subject matter is important for understanding tissue protection - Subject matter is of intense interest for new drug development
Author: Robson Faria
Publisher: BoD – Books on Demand
Published: 2020-03-11
Total Pages: 112
ISBN-13: 1789845343
DOWNLOAD EBOOKThis book aims to provide a brief update on the functions of purinergic receptors in various systems, in addition to the signaling pathway activated to mediate these functions. We address the influence of hypoxia by modulating the activity of these receptors under physiological and pathophysiological conditions. Additionally, we describe the mechanisms of induction of pain and inflammation in different systems. Finally, the book discusses some of the main bioinformatics tools currently used to improve or discover new prototypes capable of selectively acting on these receptors with estimated parameters of satisfactory solubility and toxicity for possible commercial implementation.
Author: George J. Siegel
Publisher: Lippincott Raven
Published: 1999
Total Pages: 1216
ISBN-13:
DOWNLOAD EBOOKIllustrations by Lorie M. Gavulic, MFA Sponsored by the American Society for Neurochemistry.
Author: Matthew E. Cross
Publisher: Cambridge University Press
Published: 2014-03-06
Total Pages: 439
ISBN-13: 1107615887
DOWNLOAD EBOOKA quick reference to basic science for anaesthetists, containing all the key information needed for FRCA exams.
Author: Constance N. Wilson
Publisher: Springer Science & Business Media
Published: 2009-07-28
Total Pages: 656
ISBN-13: 3540896155
DOWNLOAD EBOOKSince their discovery approximately 25 years ago, adenosine receptors have now emerged as important novel molecular targets in disease and drug discovery. These proteins play important roles in the entire spectrum of disease from inflammation to immune suppression. Because of their expression on a number of different cell types and in a number of different organ systems they play important roles in specific diseases, including asthma, rheumatoid arthritis, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, heart disease, stroke, cancer, sepsis, and obesity. As a result of intense investigations into understanding the molecular structures and pharmacology of these proteins, new molecules have been synthesized that have high specificity for these proteins and are now entering clinical trials. These molecules will define the next new classes of drugs for a number of diseases with unmet medical needs.
Author: Evamarie Hey-Hawkins
Publisher: John Wiley & Sons
Published: 2018-07-23
Total Pages: 490
ISBN-13: 1119275555
DOWNLOAD EBOOKNoted experts review the current status of boron-containing drugs and materials for molecular medical diagnostics Boron-Based Compounds offers a summary of the present status and promotes the further development of new boron-containing drugs and advanced materials, mostly boron clusters, for molecular medical diagnostics. The knowledge accumulated during the past decades on the chemistry and biology of bioorganic and organometallic boron compounds laid the foundation for the emergence of a new area of study and application of boron compounds as lipophilic pharmacophores and modulators of biologically active molecules.This important text brings together in one comprehensive volume contributions from renowned experts in the field of medicinal chemistry of boron compounds. The authors cover a range of the most relevant topics including boron compounds as modulators of the bioactivity of biomolecules, boron clusters as pharmacophores or for drug delivery, boron compounds for boron neutron capture therapy (BNCT) and for diagnostics, as well as in silico molecular modeling of boron- and carborane-containing compounds in drug design. Authoritative and accessible, Boron-Based Compounds: Contains contributions from a panel of internationally renowned experts in the field Offers a concise summary of the current status of boron-containing drugs and materials used for molecular diagnostics Highlights the range and capacity of boron-based compounds in medical applications Includes information on boron neutron capture therapy and diagnostics Designed for academic and industrial scientists, this important resource offers the cutting-edge information needed to understand the current state of boron-containing drugs and materials for molecular medical diagnostics.
Author: Pier Andrea Borea
Publisher: Humana Press
Published: 2018-07-28
Total Pages: 603
ISBN-13: 3319908081
DOWNLOAD EBOOKThis book traces the history of adenosine receptor research from molecular biology to medicinal chemistry to behavior, including their implications in disease and potential strategies as therapeutic targets. It provides the reader with a comprehensive overview of the adenosine receptors that includes information on all subtypes - A1, A2A, A2B and A3. Aspects addressed include the most up to date information on their functional distribution in the nervous and peripheral systems, behavioral roles in inflammation, cancer, pain and neurological diseases such as Huntington’s disease, Epilepsy, Parkinson’s disease and Alzheimer’s disease.
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Publisher:
Published: 2001
Total Pages:
ISBN-13:
DOWNLOAD EBOOKAuthor: Fazal-I-Akbar Danish
Publisher: CRC Press
Published: 2018-05-08
Total Pages: 160
ISBN-13: 1138031143
DOWNLOAD EBOOKPharmacological knowledge among medical students can have a very short 'half life': students often fail not because they have failed to study, but because they have been unable to retain key knowledge and reproduce it in an exam setting. This book takes an alternative route to the conventional approach of comprehensively exploring each individual drug and its features: not only can such an approach overwhelm and make knowledge retention difficult, but the current exam format makes questions structured in this way unlikely anyway. Instead of aiming to be completely comprehensive, it examines drugs systematically by classifications, mechanisms of action, therapeutic uses and side effects, enabling students to gain the distilled, functional grasp of pharmacology that their exams actually demand quickly and clearly.
Author: Stefan Bräse
Publisher: Royal Society of Chemistry
Published: 2015-11-20
Total Pages: 486
ISBN-13: 1782620303
DOWNLOAD EBOOKThis book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.
