This book is written specifically for audiologists. It is designed as a one semester course for AuD students but is also ideal for practicing professionals. It is also appropriate for other professionals wishing to know more about this area, such as clinical trials coordinators.
Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
An invaluable reference for diagnosing common auditory disorders Written by the foremost authorities in the field, Audiology: Diagnosis presents the basic concepts and essential clinical information for diagnosing auditory disorders, otologic diseases, and vestibular dysfunction. The book provides a thorough review of fundamental principles of diagnosis, including the basic procedures, the anatomy and physiology of the auditory system, imaging techniques, instrumentation, calibration, and more. It also covers the clinical tests essential for assessing the type and degree of hearing loss and for determining the etiological factors underlying the patient's disorder. Chapters address such important topics as ototoxicity and pharmacology in the audiology practice, and utilizing functional brain imaging and radiologic techniques. Highlights: New information on effective methods for neonatal hearing screening, assessment of vestibular disorders, the genetics of hearing loss, and recent advances in testing for auditory processing disorders in children and adults Chapter outlines to rapidly acquaint reader with topics to be discussed Pearls, pitfalls, controversial points, and special considerations providing recommendations and comments on key aspects of patient care Audiology: Diagnosis is one part of a three-volume series, which is completed by Audiology: Treatment and Audiology: Practice Management. Together these books provide audiologists and students in graduate programs with an invaluable resource for each stage of management.
Hearing Loss: Causes, Prevention, and Treatment covers hearing loss, causes and prevention, treatments, and future directions in the field, also looking at the cognitive problems that can develop. To avoid the "silent epidemic of hearing loss, it is necessary to promote early screening, use hearing protection, and change public attitudes toward noise. Successful treatments of hearing loss deal with restoring hearing sensitivity via hearing aids, including cochlear, brainstem, or midbrain implants. Both the technical aspects and effects on the quality of life of these devices are discussed. The integration of all aspects of hearing, hearing loss, prevention, and treatment make this a perfect one-volume course in audiology at the graduate student level. However, it is also a great reference for established audiologists, ear surgeons, neurologists, and pediatric and geriatric professionals. - Presents an in-depth overview of hearing loss, causes and prevention, treatments, and future directions in the field - Written for researchers and clinicians, such as auditory neuroscientists, audiologists, neurologists, speech pathologists, pediatricians, and geriatricians - Presents the benefits and problems with hearing aids and cochlear implants - Includes important quality of life issues
Using a case-oriented approach, this practical text provides evidence-based guidance related to the evaluation and management of persons with balance and vestibular disorders. The text benefits by the combined expertise of a neurologist, a neurotological surgeon, and a physical therapist.
The first anatomy and physiology text just for audiologists, this new text brings together some of the best professional minds in the field to consider the structures and mechanisms of the auditory system. Basic science is covered in the foundations section of the text, giving a much needed examination of the biological processes in terms the audiologist needs most. Detailed examination of the anatomy and physiology of hearing follows with diagrams and in-depth discussions. The text concludes with chapters on the pathology of hearing, covering the different causes of hearing loss, from noise-induced hearing loss to genetic aspects of hearing loss. From start to finish this text is written specifically for the audiologist, making it an essential foundational resource.
This book provides up-to-date scientific information on the pathways by which psychosocial stress can affect the auditory system and describes current approaches to the management of patients with stress-related tinnitus. The latest evidence is presented on aspects such as the role of stress hormones in auditory function, the effects of allostatic load, circadian sensitivity to auditory trauma, and the association between stress-related biomarkers and tinnitus. The clinically oriented chapters discuss psychometric instruments of value in the tinnitus clinic and present stress-related tinnitus treatment protocols and outcome measures. It is widely acknowledged that the tinnitus percept acts as a stressor. However, it is also now evident that psychosocial stress can play a causative role in tinnitus and that the impact varies according to the level, duration, and quality of the stress. Assessment of the types and levels of stress in tinnitus patients before, during, and after treatment is therefore very important. Healthcare professionals attending tinnitus patients will benefit from the information that this book provides on the relationship between tinnitus and stress and from the practical guidance that it offers.
An Essential Guide to Hearing and Balance Disorders consolidates the most significant clinical aspects of hearing and balance disorders, ranging from cause and diagnosis to treatment and cure. Experts in various subspecialties of this extensive topic introduce readers to the most sophisticated and state of the art methods of diagnosis and treatment. Each chapter expands on a specific topic area along the continuum of how medical personnel diagnose hearing and balance disorders, to how surgical implantation of the cochlea and rehabilitation can remedy various conditions. In concise format, the book begins with a case history and follows with comprehensive descriptions of current knowledge regarding fundamental causes of hearing loss and balance disorders, as well as a thorough examination of objective assessment. The latter half of the volume presents specialized treatment and rehabilitative options for various disorders. The chapters in this part cover special topics and conclude with pertinent case studies. Unique areas of discussion in a text of this kind include: genetics of deafness pediatric hearing loss and hearing loss later in life business essentials in audiology private practice professional issues, such as ethics, methods of practice, and conflicts of interest. As its title implies, this book is critically important for all students and professionals in hearing/balance related disciplines, including audiology, otolaryngology, general medicine, and rehabilitation oriented allied health care occupations.
This book illustrates, in a comprehensive manner, the most current areas of importance to Safety Pharmacology, a burgeoning unique pharmacological discipline with important ties to academia, industry and regulatory authorities. It provides readers with a definitive collection of topics containing essential information on the latest industry guidelines and overviews current and breakthrough topics in both functional and molecular pharmacology. An additional novelty of the book is that it constitutes academic, pharmaceutical and biotechnology perspectives for Safety Pharmacology issues. Each chapter is written by an expert in the area and includes not only a fundamental background regarding the topic but also detailed descriptions of currently accepted, validated models and methods as well as innovative methodologies used in drug discovery.
Tuberculosis (TB) strains with drug resistance (DR-TB) are more difficult to treat than drug-susceptible ones, and threaten global progress towards the targets set by the End TB Strategy of the World Health Organization (WHO). There is thus a critical need for evidence-based policy recommendations on the treatment and care of patients with DR-TB, based on the most recent and comprehensive evidence available. In this regard, the WHO consolidated guidelines on drug-resistant tuberculosis treatment fulfil the mandate of WHO to inform health professionals in Member States on how to improve treatment and care for patients with DR-TB. Between 2011 and 2018, WHO has developed and issued evidence-based policy recommendations on the treatment and care of patients with DR-TB. These policy recommendations have been presented in several WHO documents and their associated annexes, including the WHO treatment guidelines for multidrug- and rifampicin-resistant tuberculosis, 2018 update, issued by WHO in December 2018. The policy recommendations in each of these guidelines have been developed by WHO-convened Guideline Development Groups (GDGs), using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach to summarize the evidence, and formulate policy recommendations and accompanying remarks. The present Consolidated guidelines include a comprehensive set of WHO recommendations for the treatment and care of DR-TB, derived from these WHO guidelines documents. The consolidated guidelines include policy recommendations on treatment regimens for isoniazid-resistant TB (Hr-TB) and MDR/RR-TB, including longer and shorter regimens, culture monitoring of patients on treatment, the timing of antiretroviral therapy (ART) in MDR/RR-TB patients infected with the human immunodeficiency virus (HIV), use of surgery for patients receiving MDR-TB treatment, and optimal models of patient support and care.