Pesticide Biotransformation and Disposition
Pesticide Biotransformation and Disposition

Author: Ernest Hodgson

Publisher: Academic Press

Published: 2012-01-01

Total Pages: 236

ISBN-13: 0123854822

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Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. - Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment - Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides - Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations

Intentional Human Dosing Studies for EPA Regulatory Purposes
Intentional Human Dosing Studies for EPA Regulatory Purposes

Author: National Research Council

Publisher: National Academies Press

Published: 2004-06-04

Total Pages: 226

ISBN-13: 0309166411

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The EPA commissioned The National Academies to provide advice on the vexing question of whether and, if so, under what circumstances EPA should accept and consider intentional human dosing studies conducted by companies or other sources outside the agency (so-called third parties) to gather evidence relating to the risks of a chemical or the conditions under which exposure to it could be judged safe. This report recommends that such studies be conducted and used for regulatory purposes only if all of several strict conditions are met, including the following: The study is necessary and scientifically valid, meaning that it addresses an important regulatory question that can't be answered with animal studies or nondosing human studies; The societal benefits of the study outweigh any anticipated risks to participants. At no time, even when benefits beyond improved regulation exist, can a human dosing study be justified that is anticipated to cause lasting harm to study participants; and All recognized ethical standards and procedures for protecting the interests of study participants are observed. In addition, EPA should establish a Human Studies Review Board (HSRB) to evaluate all human dosing studiesâ€"both at the beginning and upon completion of the experimentsâ€"if they are carried out with the intent of affecting the agency's policy-making.

Pesticides in the Diets of Infants and Children
Pesticides in the Diets of Infants and Children

Author: National Research Council

Publisher: National Academies Press

Published: 1993-02-01

Total Pages: 402

ISBN-13: 0309048753

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Many of the pesticides applied to food crops in this country are present in foods and may pose risks to human health. Current regulations are intended to protect the health of the general population by controlling pesticide use. This book explores whether the present regulatory approaches adequately protect infants and children, who may differ from adults in susceptibility and in dietary exposures to pesticide residues. The committee focuses on four major areas: Susceptibility: Are children more susceptible or less susceptible than adults to the effects of dietary exposure to pesticides? Exposure: What foods do infants and children eat, and which pesticides and how much of them are present in those foods? Is the current information on consumption and residues adequate to estimate exposure? Toxicity: Are toxicity tests in laboratory animals adequate to predict toxicity in human infants and children? Do the extent and type of toxicity of some chemicals vary by species and by age? Assessing risk: How is dietary exposure to pesticide residues associated with response? How can laboratory data on lifetime exposures of animals be used to derive meaningful estimates of risk to children? Does risk accumulate more rapidly during the early years of life? This book will be of interest to policymakers, administrators of research in the public and private sectors, toxicologists, pediatricians and other health professionals, and the pesticide industry.

Recognition and Management of Pesticide Poisonings (5th Ed. )
Recognition and Management of Pesticide Poisonings (5th Ed. )

Author: J. Routt Reigart

Publisher: DIANE Publishing

Published: 2009-06

Total Pages: 238

ISBN-13: 1437914527

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This 5th ed. is an update and expansion of the 1989 4th ed. This EPA manual provides health professionals with information on the health hazards of pesticides currently in use, and current consensus recommendations for management of poisonings and injuries caused by them. As with previous updates, this new ed. incorporates new pesticide products that are not necessarily widely known among health professionals. Contents: (1) General Information: Introduction; General Principles in the Management of Acute Pesticide Poisonings; Environmental and Occupational History; (2) Insecticides; (3) Herbicides; (4) Other Pesticides; (5) Index of Signs and Symptoms; Index of Pesticide Products. Charts and tables.

Some Organophosphate Insecticides and Herbicides
Some Organophosphate Insecticides and Herbicides

Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Publisher: World Health Organization

Published: 2017

Total Pages: 0

ISBN-13: 9789283201502

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This volume of the IARC Monographs provides evaluations of the carcinogenicity of some organophosphate insecticides and herbicides, including diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. Diazinon acts on a wide range of insects on crops, gardens, livestock, and pets, but most uses have been restricted in the USA, Canada, and the European Union since the 1980s. Glyphosate is the most heavily used agricultural and residential herbicide in the world, and has been detected in soil, air, surface water, and groundwater, as well as in food. Malathion is one of the oldest and most widely used organophosphate insecticides, and has a broad spectrum of applications in agriculture and public health, notably mosquito control. The insecticide parathion has been largely banned or restricted throughout the world due to toxicity to wildlife and humans. Tetrachlorvinphos is banned in the European Union, but continues to be used in the USA and elsewhere as an insecticide on animals, including in pet flea collars. The IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of these agents.

Pesticide Toxicology and Risk Assessment
Pesticide Toxicology and Risk Assessment

Author: Muneeb U. Rehman

Publisher: CRC Press

Published: 2024-05-29

Total Pages: 301

ISBN-13: 1003858910

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With the emergence of new pesticide combinations and application methods, assessing their potential risks to non-target organisms and human well-being becomes paramount. Pesticide Toxicology and Risk Assessment focuses on the need and strategies for safe and efficient use of pesticides. It offers insights from toxicogenomics, enabling an understanding of the genetic and epigenetic factors influencing human susceptibility to chemical toxicity, thereby quantifying their impacts. This book underscores the significance of risk assessment methodologies considering real-time variables influencing pesticide exposure to the environment and humans. It provides comprehensive details about models designed to evaluate risks across a spectrum of scenarios, from worst-case to real-time situations, while outlining strategies to mitigate these risks proactively. Furthermore, this book delves into the critical need for conducting field studies, particularly in addressing innovative combinations and application techniques. Key Features: • Covers toxicogenomic insights, delving into genetic and epigenetic impacts on human susceptibility to chemical toxicity • Provides insight into necessary field studies for new pesticide approaches • Aids pesticide manufacturers with risk assessment and effective formulation insights As an aid for regulatory bodies, the book facilitates the evaluation of risks linked to both established and innovative pesticides, promoting informed decisions on usage by integrating risk reduction approaches. Simultaneously, it serves as a valuable guide for pesticide manufacturers, offering insights into using risk assessment tools to develop secure and effective pesticide blends. This guidance expedites the introduction of novel pesticides that are efficient and safe for various applications.

Chemical Pesticides Mode of Action and Toxicology
Chemical Pesticides Mode of Action and Toxicology

Author: Jørgen Stenersen

Publisher: CRC Press

Published: 2004-05-27

Total Pages: 298

ISBN-13: 9780203646830

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Environmental-friendliness, issues of public health, and the pros and cons of genetically-modified crops all receive regular coverage in the world's media. This, in turn, has led to increased questioning and investigation of chemical pesticides. Stenersen's concise and timely introduction to chemical pesticides describes these compounds according to their mode of action at the cellular and biochemical level. Chemical Pesticides provides answers to questions such as why pesticides are toxic to the target organism and why pesticides are toxic to some organisms and not others. It describes how various poisons interfere with biochemical processes in organisms. The book also explores how resistance to pesticides develops, how resistance can be used to illustrate the theory of evolution, and how it can be used to produce herbicide-resistant crop plants. Legal matters and potential environmental problems are also discussed. By providing an integrated, yet simple description of modern chemical pesticides, the author provides a relevant text for professionals and students in biological disciplines such as biochemistry, medicine, agriculture, and veterinary science.

Weed and Crop Resistance to Herbicides
Weed and Crop Resistance to Herbicides

Author: Rafael de Prado

Publisher: Springer Science & Business Media

Published: 1997-05-31

Total Pages: 366

ISBN-13: 9780792345817

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In recent decades, repeated use of herbicides in the same field has imposed selection for resistance in species that were formerly susceptible. On the other hand, considerable research in the private and public sectors has been directed towards introducing herbicide tolerance into susceptible crop species. The evolution of herbicide resistance, understanding its mechanisms, characterisation of resistant weed biotypes, development of herbicide-tolerant crops and management of resistant weeds are described throughout the 36 chapters of this book. It has been written by leading researchers based on the contributions made at the International Symposium on Weed and Crop Resistance to Herbicides held at Córdoba, Spain. This book will be a good reference source for research scientists and advanced students.

The Future Role of Pesticides in US Agriculture
The Future Role of Pesticides in US Agriculture

Author: National Research Council

Publisher: National Academies Press

Published: 2000-11-02

Total Pages: 325

ISBN-13: 0309172942

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Although chemical pesticides safeguard crops and improve farm productivity, they are increasingly feared for their potentially dangerous residues and their effects on ecosystems. The Future Role of Pesticides explores the role of chemical pesticides in the decade ahead and identifies the most promising opportunities for increasing the benefits and reducing the risks of pesticide use. The committee recommends R&D, program, and policy initiatives for federal agriculture authorities and other stakeholders in the public and private sectors. This book presents clear overviews of key factors in chemical pesticide use, including: Advances in genetic engineering not only of pest-resistant crops but also of pests themselves. Problems in pesticide useâ€"concerns about the health of agricultural workers, the ability of pests to develop resistance, issues of public perception, and more. Impending shifts in agricultureâ€"globalization of the economy, biological "invasions" of organisms, rising sensitivity toward cross-border environmental issues, and other trends. With a model and working examples, this book offers guidance on how to assess various pest control strategies available to today's agriculturist.