Peripheral Nerve Regeneration
Peripheral Nerve Regeneration

Author: Ana Colette Maurício

Publisher: BoD – Books on Demand

Published: 2017-05-31

Total Pages: 226

ISBN-13: 9535131656

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Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.

Modern Concepts of Peripheral Nerve Repair
Modern Concepts of Peripheral Nerve Repair

Author: Kirsten Haastert-Talini

Publisher: Springer

Published: 2017-06-19

Total Pages: 144

ISBN-13: 3319523198

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This book focuses on posttraumatic repair and reconstruction of peripheral nerves. Written by internationally respected specialists, it provides an overview of the challenges and the latest advances in diagnosis and treatment of traumatic peripheral nerve injuries. It presents an outline of state-of the-art procedures from diagnostics, including newest imaging techniques, over conventional and alternative surgical approaches to clinical follow-up and rehabilitation, including the latest concepts to improve functional recovery. The purely clinical topics are preceded by neuroanatomical principles and neurobiological events related to peripheral nerve transection injuries and followed by an outlook on current experimental developments in the area of biomaterials for artificial nerve grafts and peripheral nerve tissue engineering. Peripheral nerve injuries not only affect the nerve tissue at the site of injury, but also target tissue and parts of the central nervous system. They often have dramatic consequences for patients, including loss of sensory and motor functions combined with paresthesia or pain, and a reduced quality of life and ability to work. An adequate understanding of the procedures for proper decision-making and reconstructing peripheral nerves is therefore essential to ensure optimized functional recovery.

Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art
Scaffolds for Peripheral Nerve Regeneration, the Importance of In Vitro and In Vivo Studies for the Development of Cell-Based Therapies and Biomaterials: State of the Art

Author: Sílvia Santos Pedrosa

Publisher:

Published: 2017

Total Pages:

ISBN-13:

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Human adult peripheral nerve injuries are a high incidence clinical problem that greatly affects patients' quality of life. Although peripheral nervous system has intrinsic regenerative capacity, this occurs in an incomplete or poorly functional manner. When a nerve fiber loses its continuity with consequent damage of the basal lamina tubes, axon spontaneous regeneration is disorganized and mismatched. These phenomena translate in an inadequate nerve functional recovery and consequent musculoskeletal incapacity. Nerve grafts still remain the gold standard in peripheral injuries treatment. However, this approach contains its disadvantages such as the necessity of primary surgery to harvest the autografts, loss of a functional nerve, donor site morbidity and longer surgery procedures. Therefore, biomaterials and tissue engineering can provide efficient resources and alternatives to nerve injury repair not only by the development of biocompatible structures but also, introducing neurotrophic factors and cellular systems to stimulate optimum clinical outcome. In this chapter, a comprehensive state-of-the art picture of tissue-engineered nerve grafts scaffolds, their application in nerve regeneration along with latest advances in peripheral nerve repair and future perspectives will be discussed, including our own large experience in this field of knowledge.

Tissue Engineering of the Peripheral Nerve: Biomaterials and Physical Therapy
Tissue Engineering of the Peripheral Nerve: Biomaterials and Physical Therapy

Author:

Publisher: Academic Press

Published: 2013-10-01

Total Pages: 250

ISBN-13: 0124200443

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This issue of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. This volume covers the cutting-edge research on tissue engineering of the peripheral nerve

Biomaterials and Cellular Systems at the Forefront of Peripheral Nerve Regeneration
Biomaterials and Cellular Systems at the Forefront of Peripheral Nerve Regeneration

Author: Ana Colette Maurício

Publisher:

Published: 2019

Total Pages: 0

ISBN-13:

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Peripheral nerve injuries remain a common clinical complication, and currently available therapies present significant limitations, often resulting in poor and suboptimal outcomes. Despite significant developments in microsurgical approaches in the last decades, no effective treatment options have been disclosed. Current research focuses on the optimization of such microsurgical techniques and on their combination with other pro-regenerative factors, such as mesenchymal stem cells or biomaterials. Mesenchymal stem cells present a remarkable capacity for bioactive molecule production that modulates inflammatory and regenerative processes, stimulating peripheral nerve regeneration. In parallel, efforts have been directed towards the development of biomaterial nerve guidance channels and nerve conduits. These biomaterials have been optimized in terms of biodegradability, ability to release bioactive factors, incorporation of cellular agents, and internal matrix architecture (to enable cellular migration and mimic native tissue morphology and to generate and bear specific electrical activity). The current literature review presents relevant advances in the development of mesenchymal stem cell and biomaterial-based therapeutic approaches aiming at the peripheral nerve tissue regeneration in diverse lesion scenarios, also exploring the advances achieved by our research group in this field in recent years.

Peripheral Nerve Tissue Engineering and Regeneration
Peripheral Nerve Tissue Engineering and Regeneration

Author: James Phillips

Publisher: Springer

Published: 2022-07-09

Total Pages: 0

ISBN-13: 9783030210533

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This updatable book provides an accessible informative overview of the current state of the art in nerve repair research.The introduction includes history of nerve repair research and establishes key concepts and terminology and will be followed by sections that represent the main areas of interest in the field: (1) Biomaterials, (2) Therapeutic Cells, (3) Drug, Gene and Extracellular Vesicle Therapies, (4) Research Models and (5) Clinical Translation. Each section will contain 3 - 6 chapters, capturing the full breadth of relevant technology. Bringing together diverse disciplines under one overarching theme echoes the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. Each chapter will be written in an accessible manner that will facilitate interest and understanding, providing a comprehensive single reference source. The updatable nature of the work will ensure that it can evolve to accommodate future changes and new technologies. The main readership for this work will be researchers and clinicians based in academic, industrial and healthcare settings all over the world.

Cellular Biological Approaches to Treating Peripheral Nerve Injuries
Cellular Biological Approaches to Treating Peripheral Nerve Injuries

Author: P. J. Kingham

Publisher:

Published: 2015-05-22

Total Pages: 0

ISBN-13: 9783318054323

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Functional recovery after peripheral nerve injury is poor, and it has become clear that surgical reconstruction should be combined with novel therapies which address the problems of the limited rate and quantity of axonal regeneration, neuronal cell death and target organ atrophy. There is significant scope for the application of cellular and biological approaches towards peripheral nerve repair. This special topics issue begins with an introduction to the importance of Schwann cell-axon interactions which is followed by a series of papers highlighting the exciting therapeutic potential of various cell types including skin, adipose, bone marrow and hair follicle-derived adult stem cells, induced pluripotent stem cells and olfactory ensheathing cells. Another biological approach, the use of chondroitinase to overcome nerve scarring, is also described. Finally, noninvasive imaging methods, which will be necessary to determine the efficacy of these novel treatments, are reviewed. The publication will be of interest to a large number of interdisciplinary scientists including cell biologists, biomaterials scientists and chemists as well as surgeons who are involved in translational research aimed at improving the treatment of peripheral nerve injury.

Peripheral Nerve Injury An Anatomical and Physiological Approach for Physical Therapy Intervention
Peripheral Nerve Injury An Anatomical and Physiological Approach for Physical Therapy Intervention

Author: Stephen Carp

Publisher: F.A. Davis

Published: 2015-04-21

Total Pages: 384

ISBN-13: 0803645155

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Here’s everything you need to know about peripheral nerve injuries and how to recognize and treat acute and chronic injuries and conditions across the lifespan. In-depth discussions, organized in a streamlined format, ensure you understand the identification, pathophysiology, assessment, and procedural interventions associated with peripheral nerve injuries. Build the knowledge base you need to evaluate the most common to complex injuries, make a diagnosis, and implement a plan of care with this one-of-a-kind resource.