Peptide Growth Factors and Their Receptors II
Peptide Growth Factors and Their Receptors II

Author: Michael B. Sporn

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 740

ISBN-13: 3642747817

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This two-volume treatise, the collected effort of more than 50 authors, represents the first comprehensive survey of the chemistry and biology of the set of molecules known as peptide growth factors. Although there have been many symposia on this topic, and numerous publications of reviews dealing with selected subsets of growth factors, the entired field has never been covered in a single treatise. It is essential to do this at the present time, as the number of journal articles on peptide growth factors now makes it almost im anyone person to stay informed on this subject by reading the possible for At the same time it is becoming increasingly apparent that primary literature. these substances are of universal importance in biology and medicine and that the original classification of these molecules, based on the laboratory setting of their discovery, as "growth factors," "lymphokines," "cytokines," or "colony-stimulating factors," was quite artifactual; they are in fact the basis of a common language for intercellular communication. As a set they affect es sentially every cell in the body, and in this regard they provide the basis to develop a unified science of cell biology, germane to all of biomedical research.

Nuclear Localization of Growth Factors and of Monoclonal Antibodies
Nuclear Localization of Growth Factors and of Monoclonal Antibodies

Author: Ewa Rakowicz-Szulczynska

Publisher: CRC Press

Published: 1993-10-13

Total Pages: 224

ISBN-13: 9780849347139

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Nuclear Localization of Growth Factors and of Monoclonal Antibodies focuses on how an additional class of chromatin receptors is directly involved in mediation of the action of growth factors on the gene regulation level. The book describes a new intracellular pathway of growth factors and presents methods for identifying nuclear antigens with an epitopic homology of the cell surface antigens. It teaches how to distinguish monoclonal antibodies that penetrate the cell and localize in the nucleus from those that act only on the cell surface. New light is shed on the mechanisms of malignant transformation, and new approaches to developing anti-cancer and anti-HIV drugs are covered. The book will be important for oncologists, biochemists, cell biologists, pharmaceutical researchers, investigative pathologists, neurochemists, and immunologists.

Regulation of Gastrointestinal Mucosal Growth
Regulation of Gastrointestinal Mucosal Growth

Author: Rao N. Jaladanki

Publisher: Biota Publishing

Published: 2016-11-30

Total Pages: 150

ISBN-13: 1615047352

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The mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.

Proteins, Peptides and Amino Acids SourceBook
Proteins, Peptides and Amino Acids SourceBook

Author: John Stephen White

Publisher: Springer Science & Business Media

Published: 2002-04-15

Total Pages: 1071

ISBN-13: 1592591701

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Proteins, Pep tides and Amino Acids SourceBook is the second in a series of reference books conceived to cover the explosive growth in commercially available biological reagents. The success of our first reference work, Source Book of Enzymes published in 1997, encouraged us to continue this series. Choosing proteins, peptides, and amino acids as the subject matter for the second volume was simple, given their preeminence in regulating biochemical processes and their importance to modern molecular biology. The SourceBook series was inspired by our difficulty in locating a suitable replacement for a depleted reagent in the midst of an urgent research project. To our dismay, we found the reagent supplier out of business and the product line no longer available. Other reagent catalogs on our library bookshelf offered a narrow selection and incom plete functional information. We were ultimately able to locate a satisfactory alternative only by making countless inquiries and paging through innumerable product catalogs and technical data sheets. We needed-but could not find-a single resource that cataloged available compounds, organized them in a logical and accessible format, provided critical technical information to distinguish one from another, and told us where we could buy them.

Handbook of Growth Factors
Handbook of Growth Factors

Author: Enrique Pimentel

Publisher: CRC Press

Published: 1994-06-02

Total Pages: 386

ISBN-13: 9780849325052

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Volume I of this book provides a comprehensive discussion of the factors involved in regulation of the cell cycle, the general biological properties of growth factors, and the receptor and postreceptor mechanisms of action of these signaling agents. It evaluates the possible role of growth factors in the regulation of proto-oncogene and tumor suppressor gene expression, and the development of neoplastic processes is discussed in detail.

Molecular Pathology in Clinical Practice
Molecular Pathology in Clinical Practice

Author: Debra G.B. Leonard

Publisher: Springer Science & Business Media

Published: 2007-11-25

Total Pages: 589

ISBN-13: 0387332278

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This authoritative textbook embodies the current standard in molecular testing for practicing pathologists, and residents and fellows in training. The text is organized into eight sections: genetics, inherited cancers, infectious disease, neoplastic hematopathology, solid tumors, HLA typing, identity testing, and laboratory management. Discussion of each diagnostic test includes its clinical significance, available assays, quality control and lab issues, interpretation, and reasons for testing. Coverage extends to HIV, hepatitis, developmental disorders, bioterrorism, warfare organisms, lymphomas, breast cancer and melanoma, forensics, parentage, and much more. Includes 189 illustrations, 45 in full-color. This textbook is a classic in the making and a must-have reference.

Regulatory Peptides
Regulatory Peptides

Author: J.M. Polak

Publisher: Birkhäuser

Published: 2013-03-07

Total Pages: 419

ISBN-13: 3034891369

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J. M. Polak and S. R. Bloom For some time Experientia has published, as a unique feature, interdis ciplinary multi-author reviews, giving a comprehensive overview of sub jects regarded as 'growing edges' of science. The enthusiasm shown by the readers was contagious and thus it was felt necessary to compile a special volume dealing with the novel aspects of regulatory peptides. This book covers some of the growing areas in regulatory peptide research and, although it is based on the original volume of Experientia, it is expanded and updated. The topic of 'regulatory peptides' is relatively young and has grown at an unprecedented pace, from the embryonic conception of 'gut hor mones' or 'brain neuropeptides' some 15 years ago to the realisation that these active pep tides are found, almost without exception, in every part of l8 23 the body in all vertebrate and many invertebrate species • Why the term 'regulatory peptides'? It represents a convenient label encompassing both the active peptides present in nerves, which are re leased as (putative) neurotransmitters, and those in endocrine cells, which act locally or at a distance as circulating hormones, these being the l8 main components of the so-called diffuse neuroendocrine or APUD 17 system • Morphological studies support this physiological viewpoint.

Tissue Growth Factors
Tissue Growth Factors

Author: R. Baserga

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 647

ISBN-13: 3642679862

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From a logical point of view, cell division is regulated by the environment and by the ability of the cell to respond to the environmental signals. The terminology of the cell cycle, the elaborate mathematical models, and the kinetic analyses are all convenient notations and descriptions of the behavior of populations of cells. However, they tell us very little about the fundamental molecular mechanisms that control cell proliferation. Stated in other terms, what controls cell reproduction are growth factors in the environment and genes and gene products inside the cell or at its surface. This book examines the aforementioned growth factors, the study of which has made very rapid progress in the past few years. The selection of topics has been influenced by logistic considerations, but the book, as a whole, gives a broad survey of the state of the art of this exciting field. For this, thanks are due to the contributors, who have given much time to the preparation of the manuscripts and have met the deadline with a punctuality that is uncommon among biomedical scientists. I would also like to thank Ms. NORA PERRETT and the staff of Springer-Verlag for their help in editing the manuscripts and in preparing the production of the book.

Comprehensive Medicinal Chemistry III
Comprehensive Medicinal Chemistry III

Author:

Publisher: Elsevier

Published: 2017-06-03

Total Pages: 4609

ISBN-13: 0128032014

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Comprehensive Medicinal Chemistry III, Eight Volume Set provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Peptides and Protein Phosphorylation
Peptides and Protein Phosphorylation

Author: B.E. Kemp

Publisher: CRC Press

Published: 2018-01-18

Total Pages: 332

ISBN-13: 1351083899

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This comprehensive volume focuses on the ways in which synthetic peptides have been exploited in order to expand our understanding of the molecular mechanisms involved in protein phosphorylation. It recognizes that virtually all physiological processes are regulated by protein phosphorylation. It discusses the use of synthetic peptides in studying the catalytic mechanism and regulation of protein kinases. It also includes the chemical synthesis of phosphorylated peptides and preparation of specific antisera. This incredible work has lead to the development of a new generation of peptide inhibitors with potencies of greater magnitude than those previously known. Everyone involved with biochemistry and molecular biology will find this one-of-a-kind resource fascinating and filled with useful information.