This volume, developed by the Observatory together with OECD, provides an overall conceptual framework for understanding and applying strategies aimed at improving quality of care. Crucially, it summarizes available evidence on different quality strategies and provides recommendations for their implementation. This book is intended to help policy-makers to understand concepts of quality and to support them to evaluate single strategies and combinations of strategies.
The book begins by placing clinical guidelines within the context of the broader movement towards evidence based practice; it explores the concept of evidence, and defines clinical guidelines and care protocols. These are then examined in the clinical situation. The book goes on to discuss the relationship between them and the exercise of individual autonomy and expertise, and with individualised care and patient involvement and choice. The influence of cost on decision making is reviewed, and a chapter discusses the political aspects of care guidelines and protocols. Finally the book describes the implementation of guidelines and protocols and the barriers to implementation, and makes suggestions for the future.
This book provides a comprehensive overview of the proteases involved in programmed cell death. It presents a focused yet extensive discussion on proteolytic enzymes such as caspases, HtrAs, granzymes, calpains and cathepsins as well as laboratory protocols related to enzymology and apoptosis. Mouse model systems and non-invasive imaging techniques in apoptosis-related diseases such as cancer and neurodegeneration are also covered in this book. While slowly unravelling the complexities of apoptosis in chapter one, the next three chapters individually elaborate on different classes of proteases that play key roles in the initiation, progression and execution of programmed cell death. The last two chapters complete this discussion by describing different laboratory methodologies and therapeutic advances involving apoptotic proteases. Protocols portraying in vitro and ex vivo colorimetric and fluorescence-based enzyme kinetic studies as well as cell death assays are explained in the fifth chapter. Preclinical in vivo models and non-invasive imaging in apoptosis to understand the complexities of disease progression and their contribution toward therapeutics is recounted in the last chapter. The book spans topics related to both fundamental and applied biology. It would therefore be equally appealing and informative to scientists working in the field of apoptosis and those who are investigating mechanisms of proteases and enzymes in general. The protocols would certainly benefit both graduate and undergraduate students working in the related fields and provide useful leads for drug design to translational biologists involved in neurodegeneration and cancer research.
Care Pathways are being developed throughout the health service to improve the quality and effectiveness of care. Are they being developed efficiently and making the most of the latest clinical computing systems? This is the first practical guide on how Information Technology and systems methods can support the development, implementation and maintenance of Care Pathways. Case studies throughout highlight team approaches to facilitation, clinical knowledge management, process analysis and redesign, and computerisation - providing insights into how e-Pathways can be used to support high quality patient care. The information is presented in an easy-to-read style, and requires no prior knowledge of IT systems. Doctors, nurses and managers throughout primary and secondary care, as well as healthcare information technology specialists and suppliers will find this to be essential reading.
Go beyond layer 2 broadcast domains with this in-depth tour of advanced link and internetwork layer protocols, and learn how they enable you to expand to larger topologies. An ideal follow-up to Packet Guide to Core Network Protocols, this concise guide dissects several of these protocols to explain their structure and operation. This isn’t a book on packet theory. Author Bruce Hartpence built topologies in a lab as he wrote this guide, and each chapter includes several packet captures. You’ll learn about protocol classification, static vs. dynamic topologies, and reasons for installing a particular route. This guide covers: Host routing—Process a routing table and learn how traffic starts out across a network Static routing—Build router routing tables and understand how forwarding decisions are made and processed Spanning Tree Protocol—Learn how this protocol is an integral part of every network containing switches Virtual Local Area Networks—Use VLANs to address the limitations of layer 2 networks Trunking—Get an indepth look at VLAN tagging and the 802.1Q protocol Routing Information Protocol—Understand how this distance vector protocol works in small, modern communication networks Open Shortest Path First—Discover why convergence times of OSPF and other link state protocols are improved over distance vectors
The only reference tool of its kind for psychiatric health care professionals and agencies, Psychiatric Clinical Pathways: An Interdisciplinary Approach gives a wealth of practical guidance and useful real-world models you can put to work immediately. You and your staff will discover the many ways clinical pathways can be used to deliver cost-effective, quality care in a variety of settings. You'll benefit from useful models of outcomes-based care delivery systems, and practical guidelines For The delivery of quality health care and continuous quality improvement. This book is packed with information you can use immediately, including a bonus Clinical Pathways Diskette -- packed with formats and checklists your can customize to meet your needs.
Violent conflicts today are complex and increasingly protracted, involving more nonstate groups and regional and international actors. It is estimated that by 2030—the horizon set by the international community for achieving the Sustainable Development Goals—more than half of the world’s poor will be living in countries affected by high levels of violence. Information and communication technology, population movements, and climate change are also creating shared risks that must be managed at both national and international levels. Pathways for Peace is a joint United Nations†“World Bank Group study that originates from the conviction that the international community’s attention must urgently be refocused on prevention. A scaled-up system for preventive action would save between US$5 billion and US$70 billion per year, which could be reinvested in reducing poverty and improving the well-being of populations. The study aims to improve the way in which domestic development processes interact with security, diplomacy, mediation, and other efforts to prevent conflicts from becoming violent. It stresses the importance of grievances related to exclusion—from access to power, natural resources, security and justice, for example—that are at the root of many violent conflicts today. Based on a review of cases in which prevention has been successful, the study makes recommendations for countries facing emerging risks of violent conflict as well as for the international community. Development policies and programs must be a core part of preventive efforts; when risks are high or building up, inclusive solutions through dialogue, adapted macroeconomic policies, institutional reform, and redistributive policies are required. Inclusion is key, and preventive action needs to adopt a more people-centered approach that includes mainstreaming citizen engagement. Enhancing the participation of women and youth in decision making is fundamental to sustaining peace, as well as long-term policies to address the aspirations of women and young people.
"This practical guide is essential reading for all filmmakers shooting in Australia. Research and written by lawyer Terri Janke, Pathways & Protocols provides advice about the ethical and legal issues involved in transferring Indigenous cultural material to the screen. Whether shooting in country or city, with an Indigenous cast or not, practitioners of film, TV and digital media projects are encouraged to recognise and respect Indigenous people's images, knowledge, stories and land in the production of audiovisual material."--Back cover.
This volume outlines key steps associated with the design, building, and testing of synthetic metabolic pathways for optimal cell factory performance and robustness, and illustrates how data-driven learning from these steps can be used for rational cost-effective engineering of cell factories with improved performance. Chapters are divided into four sections focusing on the four steps of the iterative design-build-test-learn cycle related to modern cell factory engineering. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Metabolic Pathways: Methods and Protocols aims to ensure successful results in the further study of this vital field.
