Exploring breakthroughs in fungal detection and control, this book covers fungal nomenclature, population instability, and phylogeny, as well as investigative research on Peronosporomycetes, Zygomycetes, Filamentous Ascomycetes, Basidiomycetous Yeasts, Endomycetes and Blastomycetes, and Miscellaneous Opportunistic Fungi. It offers methods to identi
The importance of fungal infections in both human and animals has increased over the last few decades. This book presents an overview of the different categories of fungal infections that can be encountered in animals (including lower vertebrates) originating from environmental sources with or without transmission to humans. In addition, the endemic infections with indirect transmission from the environment, the zoophilic fungal pathogens with near-direct transmission, the zoonotic fungi that can be directly transmitted from animals to humans, mycotoxicoses and antifungal resistance in animals will also be discussed. This book includes case studies and reviews the current state of knowledge on the mechanism of fungal attraction, recognition, infection, extracellular hydrolytic enzymes and pathogenesis of nematophagous fungi. The book also covers diagnostics, fungal formulations, as well as prevention methods. It discusses strategies to access the fungal pathogen groups, metagenomic analyses, genomics, secretomics, metabolomics, proteomics and transcriptomics. In addition, pathogen description, understanding, distribution and recent research results are provided.
Fungal diseases have contributed to death and disability in humans, triggered global wildlife extinctions and population declines, devastated agricultural crops, and altered forest ecosystem dynamics. Despite the extensive influence of fungi on health and economic well-being, the threats posed by emerging fungal pathogens to life on Earth are often underappreciated and poorly understood. On December 14 and 15, 2010, the IOM's Forum on Microbial Threats hosted a public workshop to explore the scientific and policy dimensions associated with the causes and consequences of emerging fungal diseases.
This book provides in-depth insights into epidemic and emerging mycoses in various animal groups. The different categories of pathogens and outbreak fungi are discussed. In an introductory chapter, the reader will be provided basic information on fungal infections that are non-transmissible, infections from a common environmental source known as sapronoses, and zoophilic fungal pathogens in various animal species and populations, worldwide Chapter 2 details the vocabulary and terminology that is required in the scientific literature in order to maintain clarity of expression to the field of Mycology. Chapters 3 to 9 discuss epidemic mycoses with a reservoir in animals and occasional outbreaks, including dermatophytoses, coccidioidomycosis, histoplasmosis, paracoccidioidomycosis, adiaspiromycosis and similar diseases, blastomycosis, and paracoccidioidomycosis ceti (lacaziosis/lobomycosis). Chapters 10 to 15 comprise emerging mycoses in animals that include feline sporotrichosis, lethargic crab disease, emergence of C. gattii in animals and zoonotic potential, white-nose syndrome in hibernating bats, chytridiomycosis in frogs and salamanders and aspergillosis in cats. The last chapter is about treatment possibilities, antifungal use in veterinary practice, and emergence of resistance. The book will address medical and veterinary mycologists, microbiologists, veterinarians, infectious disease specialists, epidemiologists, ecologists, public health scientists from academia and industry as well as graduate students, PhD students and postdocs in the field.
This treatise is focused on early aspects of fungal pathogenesis in plant and animal hosts. Our aim in choosing the topics and contributors was to demonstrate common approaches to studies of fungal-plant and fungal-animal interactions, particularly at the biochemical and molecular Ievels. For example, the initial events of adh«sion of fungal spores to the exposed surface tissues of the host are essential for subsequent invasion of the plant or animal and establishment of pathogenesis. A point of consensus among investigators who have directed their attention to such events in plants, insects, and vertebrates isthat spore adhesion to the host cuticle or epithelium is more than a simple binding event. lt is a complex and potentially pivotal process in fungal-plant interactions which "may involve the secretion of ftuids that prepare the infection court for the development of morphological stages of the germling" and subsequent invasion of the host (Nicholson and Epstein, Chapter 1). The attachment of the fungal propagule to the arthropod cuticle is also "mediated by the chemical components present on the outer layer of the spore wall and the epicuticle . . . . Initial attachment may be reinforced further by either the active secretion of adhesive materials or the modification of spore wall materiallocated at the [fungal spore arthropod] cuticle interface (Boucias and Pendland, Chapter 5).
Fungal pathogens pose an on-going and serious threat for poikilotherms and homeotherms, and can cause a broad spectrum of diseases ranging from innocuous to life-threatening. In addition, long-term exposure to some mycotoxigenic moulds can lead to mycotoxicoses in human and animals. Given the expanding population of immune compromised hosts, the list of fungal opportunists grows longer every year. Moreover, antifungal resistance, drug-related toxicity and our limited arsenal of antifungals have exacerbated the situation. To address these problems, strategies such as the identification of novel targets, use of the structure-activity relationship in rational drug design, development of new formulations, modification of existing antifungals to combat resistance, and bioavailability enhancement are called for. For the reader’s convenience, this book has been divided into three sections. The first six chapters of Section I provide a timely review of mycoses, from endemic to cosmopolitan and from generalized to specific, while both chapters of Section II focus on risks associated with mycotoxins. In closing, the two chapters of Section III describe potential antifungal leads and drug candidates based on phytochemicals and coumarin scaffold.
Fungi research and knowledge grew rapidly following recent advances in genetics and genomics. This book synthesizes new knowledge with existing information to stimulate new scientific questions and propel fungal scientists on to the next stages of research. This book is a comprehensive guide on fungi, environmental sensing, genetics, genomics, interactions with microbes, plants, insects, and humans, technological applications, and natural product development.
The Oxford Textbook of Medical Mycology is a comprehensive reference text which brings together the science and medicine of human fungal disease. Written by a leading group of international authors to bring a global expertise, it is divided into sections that deal with the principles of mycology, the organisms, a systems based approach to management, fungal disease in specific patient groups, diagnosis, and treatment. The detailed clinical chapters take account of recent international guidelines on the management of fungal disease. With chapters covering recent developments in taxonomy, fungal genetics and other 'omics', epidemiology, pathogenesis, and immunology, this textbook is well suited to aid both scientists and clinicians. The extensive illustrations, tables, and in-depth coverage of topics, including discussion of the non-infective aspects of allergic and toxin mediated fungal disease, are designed to aid the understanding of mechanisms and pathology, and extend the usual approach to fungal disease. This textbook is essential reading for microbiologists, research scientists, infectious diseases clinicians, respiratory physicians, and those managing immunocompromised patients. Part of the Oxford Textbook in Infectious Disease and Microbiology series, it is also a useful companion text for students and trainees looking to supplement mycology courses and microbiology training.
This substantially updated edition now in full colour provides key techniques used when working with fungal and fungal-like plant pathogens. As a practical manual it also deals with disease recognition, detection and identification of fungi, plus methods to characterise and curate fungi and handle them under quarantine and quality assurance systems. Fungal Plant Pathogens: Applied Techniques, 2nd edition provides a valuable guide to investigating fungal plant diseases and interpreting laboratory findings for postgraduate and advanced undergraduate students, extension plant pathologists, consultants and advisers in agriculture, forestry and horticulture, and the food supply chain.
