Organometallics in Synthesis
Organometallics in Synthesis

Author: Bruce H. Lipshutz

Publisher: John Wiley & Sons

Published: 2013-12-02

Total Pages: 528

ISBN-13: 1118651448

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Provides detailed procedures and useful hints on organometallic reactions of Cu, Rh, Ni, and Au With contributions from leading organic chemists who specialize in the use of organometallics in organic synthesis, this acclaimed Manual offers an especially valuable resource for all synthetic chemists, providing a practical reference for conducting transition metal mediated synthetic reactions. This Fourth Manual is divided into four chapters: Chapter I: Organocopper Chemistry Chapter II: Organorhodium Chemistry Chapter III: Organonickel Chemistry Chapter IV: Organogold Chemistry Each of these newly written chapters features detailed, practical examples from the literature that guide readers through the preparation of organometallic reagents and their applications in organic synthesis. Procedures are presented in the Manual's acclaimed step-by-step recipe format, enabling both novices and experienced synthetic chemists to perform all the reactions with ease. In addition, the Manual features: Extensive background information on the organometallic chemistry of Cu, Rh, Ni, and Au References to the primary literature facilitating further investigation of all the reactions covered in the Manual Mechanistic considerations to help readers better understand how the desired products are formed Future research opportunities for each organometallic class Organometallics in Synthesis provides extensive and detailed information enabling synthetic chemists to readily assess the applicability of a synthetic method to a given need, and then to perform the reaction with confidence. The Manual covers both established organometallic procedures along with the most recently published protocols. Industrial processes are increasingly relying on organometallic chemistry. In this Manual, readers will find applications to such fields as natural products total synthesis, pharmaceuticals, fine chemicals, biotechnology, agricultural science, polymers, and materials science.

Organometallics in Synthesis
Organometallics in Synthesis

Author: Manfred Schlosser

Publisher: John Wiley & Sons

Published: 2013-04-15

Total Pages: 1028

ISBN-13: 047012217X

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WINNER of the 2013 PROSE Award in Chemistry & Physics This latest edition enables readers to master new classes of organometallic compounds and syntheses A popular resource used by synthetic organic chemists around the world, this book enables readers to conduct seamless synthetic reactions involving key organometallics. Each reaction is set forth in the book's acclaimed recipe-style format so that readers can easily replicate the results in their own labs. Moreover, each chapter has been written by a world leader in the field of organometallics in organic synthesis. These authors offer hands-on guidance and practical examples illustrating the preparation of organometallics and its application in organic synthesis. This Third Manual of Organometallics in Synthesis features completely new content and topics, with an eye towards providing researchers with the most useful and practical reference on the synthesis of organometallics. Organized into chapters by type of organometallic compound, the book covers: Organoalkali chemistry Organomagnesium and organozinc chemistry Organosilicon and relating organotin chemistry Organoiron chemistry Organopalladium chemistry Within each chapter, readers will find background information to learn more about the class of organometallics as well as mechanistic considerations. The authors thoroughly discuss the various methods of preparing the organometallic compounds presented in the book and outline their uses in synthetic reactions. In addition to current applications, the authors explore future research opportunities for each organometallic class. References at the end of each chapter enable readers to explore all the topics in greater depth. More and more industrial processes rely on organometallic chemistry. As a result, readers will find this book's step-by-step instructions essential in such fields as natural product synthesis, pharmaceuticals, fine chemicals, biotechnology, polymers, and materials science.

Transition metal Organometallics In Organic Synthesis
Transition metal Organometallics In Organic Synthesis

Author: Howard Alper

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 270

ISBN-13: 9780323161930

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Transition Metal Organometallics in Organic Synthesis: Volume I reviews the literature in the field of organic synthesis with a focus on the most effective synthetic transformations. The text covers topics such as the general considerations in organic synthesis, C-C and C-X bond formations, and the isomerization and reorganization reactions of olefins. Also covered are topics such as displacement reactions with transition metal complexes, electrophilic reactions of organopalladium complexes, carbonylation reactions, and metal-carbene complexes — its structure, spectra, bonding, and direct synthesis. The book is recommended as a reference for chemists and inorganic chemists who would like to learn the applications of organometallic complexes as reagents and catalysts.

Synthesis of Organometallic Compounds
Synthesis of Organometallic Compounds

Author: Sanshiro Komiya

Publisher: John Wiley & Sons

Published: 1997-05-28

Total Pages: 450

ISBN-13: 0471971952

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Inorganic Chemistry: Inorganic Chemistry: A Textbook Series This series reflects the breadth of modern research in inorganic chemistry and fulfils the need for advanced texts. The series covers the whole range of inorganic and physical chemistry, solid state chemistry, coordination chemistry, main group chemistry and bioinorganic chemistry. Synthesis of Organometallic Compounds A Practical Guide Edited by Sanshiro Komiya Tokyo University of Agriculture and Technology, Japan. This book describes the concepts of organometallic chemistry and provides an overview of the chemistry of each metal including the synthesis and handling of its important organometallic compounds. Synthesis of Organometallic Compounds: A Practical Guide provides: an excellent introduction to organometallic synthesis detailed synthetic protocols for the most important organometallic syntheses an overview of the reactivity, applications and versatility of organometallic compounds a survey of metals and their organometallic derivatives The purpose of this book is to serve as a practical guide to understanding the general concepts of organometallics for graduate students and scientists who are not necessarily specialists in organometallic chemistry.

Organometallic Chemistry in Industry
Organometallic Chemistry in Industry

Author: Thomas J. Colacot

Publisher: John Wiley & Sons

Published: 2020-05-26

Total Pages: 336

ISBN-13: 3527345175

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Showcases the important role of organometallic chemistry in industrial applications and includes practical examples and case studies This comprehensive book takes a practical approach to how organometallic chemistry is being used in industrial applications. It uniquely offers numerous, real-world examples and case studies that aid working R&D researchers as well as Ph.D. and postdoc students preparing to ace interviews in order to enter the workforce. Edited by two world-leading and established industrial chemists, the book covers flow chemistry (catalytic and non-catalytic organometallic chemistry), various cross-coupling reactions (C-C, C-N, and C-B) in classical batch chemistry, conjugate addition reactions, metathesis, and C-H arylation and achiral hydrogenation reactions. Beginning with an overview of the many industrial milestones within the field over the years, Organometallic Chemistry in Industry: A Practical Approach provides chapters covering: the design, development, and execution of a continuous flow enabled API manufacturing route; continuous manufacturing as an enabling technology for low temperature organometallic chemistry; the development of a nickel-catalyzed enantioselective Mizoroki-Heck coupling; and the development of iron-catalyzed Kumada cross-coupling for the large scale production of Aliskiren intermediates. The book also examines aspects of homogeneous hydrogenation from industrial research; the latest industrial uses of olefin metathesis; and more. -Includes rare industrial case studies difficult to find in current literature -Helps readers successfully carry out their own reactions -Covers topics like flow chemistry, cross-coupling reactions, and dehydrative decarbonylation -Features a foreword by Nobel Laureate R. H. Grubbs -A perfect resource for every R&D researcher in industry -Useful for PhD students and postdocs: excellent preparation for a job interview Organometallic Chemistry in Industry: A Practical Approach is an excellent resource for all chemists, including those working in the pharmaceutical industry and organometallics.

Organometallic Mechanisms and Catalysis
Organometallic Mechanisms and Catalysis

Author: Jay Kochi

Publisher: Elsevier

Published: 2012-12-02

Total Pages: 642

ISBN-13: 0323144101

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Organometallic Mechanisms and Catalysis: The Role of Reactive Intermediates in Organic Processes covers the mechanistic delineation of organometallic chemistry and catalysis. This book is organized into three parts encompassing 18 chapters. The first part describes first the oxidation-reduction process of organometals, followed by discussions on the catalytic reactions of peroxides, metal-catalyzed addition to olefins, and reduction of organic halides. This part also explores other reactions involving transition metal carbonyls and metal-catalyzed reactions of aromatic diazonium salts. The second part deals with some chemical aspects of organometals, such as their stability, thermochemistry, decomposition, hemolytic pathways, and the formation of carbon-carbon bonds. The third part examines the charge transfer processes and interactions of organometals with electron acceptors. This part further looks into the cleavage and insertion reactions of organometals with electrophiles, as well as the electrophilic and electron transfer mechanisms of organometals. Organic and inorganic chemists, teachers, and students will greatly benefit from this book.

Carbon Dioxide and Organometallics
Carbon Dioxide and Organometallics

Author: Xiao-Bing Lu

Publisher: Springer

Published: 2015-08-26

Total Pages: 313

ISBN-13: 3319220780

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The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics of pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors. All chapters from Topics in Organometallic Chemistry are published OnlineFirst with an individual DOI. In references, Topics in Organometallic Chemistry is abbreviated as Top Organomet Chem and cited as a journal

Transition Metals in the Synthesis of Complex Organic Molecules
Transition Metals in the Synthesis of Complex Organic Molecules

Author: Louis S. Hegedus

Publisher: University Science Books

Published: 1999

Total Pages: 358

ISBN-13: 9781891389047

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This second edition offers easy access to the field of organotransition metal chemistry. The book covers the basics of transition metal chemistry, giving a practical introduction to organotransition reaction mechanisms.

Organometallics as Catalysts in the Fine Chemical Industry
Organometallics as Catalysts in the Fine Chemical Industry

Author: Matthias Beller

Publisher: Springer

Published: 2012-08-31

Total Pages: 165

ISBN-13: 3642328334

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Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoît Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

Main-Group Metal Organometallics in Organic Synthesis
Main-Group Metal Organometallics in Organic Synthesis

Author: A. McKillop

Publisher: Elsevier

Published: 2004-09-16

Total Pages: 698

ISBN-13: 9780080423180

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The individual chapters in this volume cover the scope and impact of main group organometallic compounds and reagents on organic synthesis during the last ten to fifteen years. In a number of chapters, topics are dealt with in detail that either were not covered at all in COMC (eg selenium, tellurium) or were given scant attention (eg oxymercuration, organoantimony compounds). Certain topics, like directed metallation and LiKOR bases have only achieved prominence in synthesis in the last ten years, and are now reviewed by leading experts.