Skin Tissue Engineering and Regenerative Medicine
Skin Tissue Engineering and Regenerative Medicine

Author: Mohammad Albanna

Publisher: Academic Press

Published: 2016-01-14

Total Pages: 468

ISBN-13: 012801797X

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The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. - Explores cellular and molecular processes of wound healing, scar formation, and dermal repair - Includes examples of animal models for wound healing and translation to the clinical world - Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management - Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages
On Tissue Engineering and Regenerative Medicine of Skin and Its Appendages

Author: Marianna Bei

Publisher: Frontiers Media SA

Published: 2019-11-01

Total Pages: 109

ISBN-13: 2889631079

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Skin is the largest organ of the body and is necessary for survival, since it performs many functions such as providing a physical barrier to the external environment, sensation, retention of normal hydration and thermal regulation. Significant skin loss is associated with high mortality and morbidity in the acute phase, and with physically and cosmetically drastic scarring in the long term. Although there are a number of tissue-engineered products in the clinic that are used as skin substitutes to promote healing of traumatic burn and diabetic wounds, yet they lack several important functions including those provided by the appendages such as the hair follicles, sebaceous and sweat glands. The understanding of cellular, molecular and engineering aspects of the pathology, repair and/or regeneration of skin after wound induction is of paramount importance in order to develop the next generation of tissue engineered products with gene-enhanced capacity. In that context, we brought together scientists from basic research, translational and bioengineering fields, whose work focus on cutting-edge research associated with the acquisition of new therapeutic approaches towards skin regeneration.

Skin Tissue Engineering
Skin Tissue Engineering

Author: Sophie Böttcher-Haberzeth

Publisher: Springer Nature

Published: 2019-05-30

Total Pages: 260

ISBN-13: 1493994735

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This volume provides protocols describing the isolation and culture of diverse cell types stemming from the skin and the use of these cells and cell constructs for wound healing, bioengineering applications, and translational medicine purposes. The book is divided into three sections describing the isolation and culture of diverse skin cells, managing these cells within co-culture systems and skin models, as well as using these skin models in a test setting. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Skin Tissue Engineering: Methods and Protocols serves as a vital aid to basic and clinical researchers such as biologists, physicians, and biomedical engineers working with and being interested in basic science, and clinically and laboratory-applicable translational regenerative medicine.

Regenerative Biology and Medicine
Regenerative Biology and Medicine

Author: David L. Stocum

Publisher: Academic Press

Published: 2012-06-07

Total Pages: 474

ISBN-13: 012384861X

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Regenerative Biology and Medicine, Second Edition — Winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — discusses the fundamentals of regenerative biology and medicine. It provides a comprehensive overview, which integrates old and new data into an ever-clearer global picture. The book is organized into three parts. Part I discusses the mechanisms and the basic biology of regeneration, while Part II deals with the strategies of regenerative medicine developed for restoring tissue, organ, and appendage structures. Part III reflects on the achievements of regenerative biology and medicine; future challenges; bioethical issues that need to be addressed; and the most promising developments in regenerative medicine. The book is designed for multiple audiences: undergraduate students, graduate students, medical students and postdoctoral fellows, and research investigators interested in an overall synthesis of this field. It will also appeal to investigators from fields not directly related to regenerative biology and medicine, such as chemistry, informatics, computer science, mathematics, physics, and engineering. - Highly Commended 2013 BMA Medical Book Award for Medicine - Includes coverage of skin, hair, teeth, cornea, and central neural tissues - Provides description of regenetive medicine in digestive, respiratory, urogenital, musculoskeletal, and cardiovascular systems - Includes amphibians as powerful research models with discussion of appendage regeneration in amphibians and mammals

Textbook on Scar Management
Textbook on Scar Management

Author: Luc Téot

Publisher: Springer Nature

Published: 2020-12-07

Total Pages: 553

ISBN-13: 3030447669

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This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners

Stem Cells
Stem Cells

Author: Mary Clarke

Publisher: Garland Science

Published: 2020-07-27

Total Pages: 966

ISBN-13: 1000062651

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Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Nanotechnology Applications for Tissue Engineering
Nanotechnology Applications for Tissue Engineering

Author: Sabu Thomas

Publisher: William Andrew

Published: 2015-01-03

Total Pages: 336

ISBN-13: 0323353037

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Tissue engineering involves seeding of cells on bio-mimicked scaffolds providing adhesive surfaces. Researchers though face a range of problems in generating tissue which can be circumvented by employing nanotechnology. It provides substrates for cell adhesion and proliferation and agents for cell growth and can be used to create nanostructures and nanoparticles to aid the engineering of different types of tissue. Written by renowned scientists from academia and industry, this book covers the recent developments, trends and innovations in the application of nanotechnologies in tissue engineering and regenerative medicine. It provides information on methodologies for designing and using biomaterials to regenerate tissue, on novel nano-textured surface features of materials (nano-structured polymers and metals e.g.) as well as on theranostics, immunology and nano-toxicology aspects. In the book also explained are fabrication techniques for production of scaffolds to a series of tissue-specific applications of scaffolds in tissue engineering for specific biomaterials and several types of tissue (such as skin bone, cartilage, vascular, cardiac, bladder and brain tissue). Furthermore, developments in nano drug delivery, gene therapy and cancer nanotechonology are described. The book helps readers to gain a working knowledge about the nanotechnology aspects of tissue engineering and will be of great use to those involved in building specific tissue substitutes in reaching their objective in a more efficient way. It is aimed for R&D and academic scientists, lab engineers, lecturers and PhD students engaged in the fields of tissue engineering or more generally regenerative medicine, nanomedicine, medical devices, nanofabrication, biofabrication, nano- and biomaterials and biomedical engineering. - Provides state-of-the-art knowledge on how nanotechnology can help tackling known problems in tissue engineering - Covers materials design, fabrication techniques for tissue-specific applications as well as immunology and toxicology aspects - Helps scientists and lab engineers building tissue substitutes in a more efficient way

Skin Bioengineering
Skin Bioengineering

Author: Peter Elsner

Publisher: Karger Medical and Scientific Publishers

Published: 1998-01-01

Total Pages: 259

ISBN-13: 3805565194

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Non-invasive bioengineering techniques have become indispensable tools both in the development of drugs and cosmetics and in clinical dermatology. These techniques enable researchers to study the structure and function of human skin objectively and quantitatively. Recent technological developments have brought new techniques into the laboratory and the hospital, among them magnetic resonance imaging, optical coherence tomography and microdialysis. This book describes these state-of-the-art developments, details the application of skin bioengineering techniques for clinical purposes, shows their use in the testing of pharmaceutics and cosmetics and provides an overview of the design and legal aspects of skin bioengineering testing. It will be essential reading for dermatologists, cosmetologists, pharmacologists and toxicologists.