The Evolution of Vertebrate Blood Clotting

The Evolution of Vertebrate Blood Clotting

Author: Russell F. Doolittle

Publisher: University Science Books

Published: 2012-11-15

Total Pages: 0

ISBN-13: 9781891389818

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llluminated by a great assortment of original illustrations, this remarkable book charts the step-by-step evolution of vertebrate blood coagulation. Intended for readers with a background in biological science, it is specifically targeted for those in the field of molecular evolution as well as for researchers in the area of blood clotting. After providing some general background in the areas of blood clotting, protein structure, animal systematics, and simple genomics, the book focusses in on the search for blood clotting genes in the genomes of non-mammalian vertebrates, including fish, amphibians, reptiles and birds. The inventory of genes found allows a reconstruction of events culminating in the complex clotting system observed in humans and other mammals. Also examined are the genomes of protochordates like the sea squirt, leading to conjecture about how blood clotting was first initiated. The orderly way in which gene duplications provided new genes for fine-tuning the system serves as a model for how complex physiological systems in general have evolved. The book ends with suggestions for specific genetic engineering experiments that can be done to illustrate how molecular evolution works. An extensive glossary and guide to the current literature combine to make this book ideal for course use as well as for self study.


Pediatric Hematology

Pediatric Hematology

Author: Robert Wynn

Publisher: Cambridge University Press

Published: 2017-02-16

Total Pages: 299

ISBN-13: 1107439361

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A succinct summary of the key principles and facts that guide the everyday practice of modern, clinical paediatric hematology. Covering all the information necessary for examinations in the topic, this book is ideal for postgraduates studying paediatric hematology, as well as for junior doctors in training.


Trauma Induced Coagulopathy

Trauma Induced Coagulopathy

Author: Hunter B. Moore

Publisher: Springer Nature

Published: 2020-10-12

Total Pages: 802

ISBN-13: 3030536068

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The first edition of this publication was aimed at defining the current concepts of trauma induced coagulopathy by critically analyzing the most up-to-date studies from a clinical and basic science perspective. It served as a reference source for any clinician interested in reviewing the pathophysiology, diagnosis, and management of the coagulopathic trauma patient, and the data that supports it. By meticulously describing the methodology of most traditional as well as state of the art coagulation assays the reader is provided with a full understanding of the tests that are used to study trauma induced coagulopathy. With the growing interest in understanding and managing coagulation in trauma, this second edition has been expanded to 46 chapters from its original 35 to incorporate the massive global efforts in understanding, diagnosing, and treating trauma induced coagulopathy. The evolving use of blood products as well as recently introduced hemostatic medications is reviewed in detail. The text provides therapeutic strategies to treat specific coagulation abnormalities following severe injury, which goes beyond the first edition that largely was based on describing the mechanisms causing coagulation abnormalities. Trauma Induced Coagulopathy 2nd Edition is a valuable reference to clinicians that are faced with specific clinical challenges when managing coagulopathy.


Only a Theory

Only a Theory

Author: Kenneth Raymond Miller

Publisher: Penguin

Published: 2008

Total Pages: 260

ISBN-13: 9780670018833

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Evaluates the debate between advocates for evolution and intelligent design which occured during the 2005 Dover evolution trial, dissecting the claims of the intelligent design movement and explaining why the conflict is compromising America's position a


Mutation and Evolution

Mutation and Evolution

Author: Ronny C. Woodruff

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 561

ISBN-13: 9401152101

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Although debated since the time of Darwin, the evolutionary role of mutation is still controversial. In over 40 chapters from leading authorities in mutation and evolutionary biology, this book takes a new look at both the theoretical and experimental measurement and significance of new mutation. Deleterious, nearly neutral, beneficial, and polygenic mutations are considered in their effects on fitness, life history traits, and the composition of the gene pool. Mutation is a phenomenon that draws attention from many different disciplines. Thus, the extensive reviews of the literature will be valuable both to established researchers and to those just beginning to study this field. Through up-to-date reviews, the authors provide an insightful overview of each topic and then share their newest ideas and explore controversial aspects of mutation and the evolutionary process. From topics like gonadal mosaicism and mutation clusters to adaptive mutagenesis, mutation in cell organelles, and the level and distribution of DNA molecular changes, the foundation is set for continuing the debate about the role of mutation, fitness, and adaptability. It is a debate that will have profound consequences for our understanding of evolution.


Why Evolution is True

Why Evolution is True

Author: Jerry A. Coyne

Publisher: OUP Oxford

Published: 2010-01-14

Total Pages: 416

ISBN-13: 019164384X

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For all the discussion in the media about creationism and 'Intelligent Design', virtually nothing has been said about the evidence in question - the evidence for evolution by natural selection. Yet, as this succinct and important book shows, that evidence is vast, varied, and magnificent, and drawn from many disparate fields of science. The very latest research is uncovering a stream of evidence revealing evolution in action - from the actual observation of a species splitting into two, to new fossil discoveries, to the deciphering of the evidence stored in our genome. Why Evolution is True weaves together the many threads of modern work in genetics, palaeontology, geology, molecular biology, anatomy, and development to demonstrate the 'indelible stamp' of the processes first proposed by Darwin. It is a crisp, lucid, and accessible statement that will leave no one with an open mind in any doubt about the truth of evolution.


Darwin's Black Box

Darwin's Black Box

Author: Michael J. Behe

Publisher: Simon and Schuster

Published: 1996

Total Pages: 353

ISBN-13: 9780684827544

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Behe argues that the complexity of cellular biochemistry argues against Darwin's gradual evolution.


Creationism's Trojan Horse

Creationism's Trojan Horse

Author: Barbara Forrest

Publisher: Oxford University Press

Published: 2007

Total Pages: 447

ISBN-13: 0195319737

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The Wedge has intruded itself successfully into educational politics at the local, state, and now national levels."--BOOK JACKET.