Statistical Analysis of Ecotoxicity Studies
Statistical Analysis of Ecotoxicity Studies

Author: John W. Green

Publisher: John Wiley & Sons

Published: 2018-08-14

Total Pages: 416

ISBN-13: 1119088348

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A guide to the issues relevant to the design, analysis, and interpretation of toxicity studies that examine chemicals for use in the environment Statistical Analysis of Ecotoxicity Studies offers a guide to the design, analysis, and interpretation of a range of experiments that are used to assess the toxicity of chemicals. While the book highlights ecotoxicity studies, the methods presented are applicable to the broad range of toxicity studies. The text contains myriad datasets (from laboratory and field research) that clearly illustrate the book's topics. The datasets reveal the techniques, pitfalls, and precautions derived from these studies. The text includes information on recently developed methods for the analysis of severity scores and other ordered responses, as well as extensive power studies of competing tests and computer simulation studies of regression models that offer an understanding of the sensitivity (or lack thereof) of various methods and the quality of parameter estimates from regression models. The authors also discuss the regulatory process indicating how test guidelines are developed and review the statistical methodology in current or pending OECD and USEPA ecotoxicity guidelines. This important guide: Offers the information needed for the design and analysis to a wide array of ecotoxicity experiments and to the development of international test guidelines used to assess the toxicity of chemicals Contains a thorough examination of the statistical issues that arise in toxicity studies, especially ecotoxicity Includes an introduction to toxicity experiments and statistical analysis basics Includes programs in R and excel Covers the analysis of continuous and Quantal data, analysis of data as well as Regulatory Issues Presents additional topics (Mesocosm and Microplate experiments, mixtures of chemicals, benchmark dose models, and limit tests) as well as software Written for directors, scientists, regulators, and technicians, Statistical Analysis of Ecotoxicity Studies provides a sound understanding of the technical and practical issues in designing, analyzing, and interpreting toxicity studies to support or challenge chemicals for use in the environment.

Marine Ecotoxicology
Marine Ecotoxicology

Author: Julián Blasco

Publisher: Academic Press

Published: 2016-08-05

Total Pages: 334

ISBN-13: 012803372X

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Marine Ecotoxicology: Current Knowledge and Future Issues is the first unified resource to cover issues related to contamination, responses, and testing techniques of saltwater from a toxicological perspective. With its unprecedented focus on marine environments and logical chapter progression, this book is useful to graduate students, ecotoxicologists, risk assessors, and regulators involved or interested in marine waters. As human interaction with these environments increases, understanding of the pollutants and toxins introduced into the oceans becomes ever more critical, and this book builds a foundation of knowledge to assist scientists in studying, monitoring, and making decisions that affect both marine environments and human health. A team of world renowned experts provide detailed analyses of the most common contaminants in marine environments and explain the design and purpose of toxicity testing methods, while exploring the future of ecotoxicology studies in relation to the world’s oceans. As the threat of increasing pollution in marine environments becomes an ever more tangible reality, Marine Ecotoxicology offers insights and guidance to mitigate that threat. Provides practical tools and methods for assessing and monitoring the accumulation and effects of contaminants in marine environments Unites world renowned experts in marine ecotoxicology to deliver thorough and diverse perspectives Builds the foundation required for risk assessors and regulators to adequately assess and monitor the impact of pollution in marine environments Offers helpful insights and guidance to graduate students, ecotoxicologists, risk assessors, and regulators interested in mitigating threats to marine waters

OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 249: Fish Cell Line Acute Toxicity - The RTgill-W1 cell line assay
OECD Guidelines for the Testing of Chemicals, Section 2 Test No. 249: Fish Cell Line Acute Toxicity - The RTgill-W1 cell line assay

Author: OECD

Publisher: OECD Publishing

Published: 2021-06-18

Total Pages: 51

ISBN-13: 9264714138

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The RTgill-W1 cell line assay describes a 24-well plate format fish cell line acute toxicity test using the permanent cell line from rainbow trout (Oncorhynchus mykiss) gill, RTgill-W1. After 24 h of exposure to the test chemical, cell viability is assessed based on three fluorescent cell viability indicator dyes, measured on the same set of cells. Resazurin enters the cells in its non-fluorescent form and is converted to the fluorescent product, resorufin, by mitochondrial, microsomal or cytoplasmic oxidoreductases.

OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Report of the OECD Workshop on Statistical Analysis of Aquatic Toxicity Data
OECD Guidelines for the Testing of Chemicals / OECD Series on Testing and Assessment Report of the OECD Workshop on Statistical Analysis of Aquatic Toxicity Data

Author: OECD

Publisher: OECD Publishing

Published: 2002-05-10

Total Pages: 133

ISBN-13: 9264078282

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The workshop report reviews the options available for the analysis of data from ecotoxicity tests; compares their advantages and disadvantages; a recommends (a) the most appropriate approach for deriving summary parameter(s) and (b) further work to be undertaken.

OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment
OECD Series on Testing and Assessment Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment

Author: OECD

Publisher: OECD Publishing

Published: 2017-04-13

Total Pages: 23

ISBN-13: 9264274820

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With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to testing and assessment that can be used as one of ...