OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay

Author: OECD

Publisher: OECD Publishing

Published: 2022-06-30

Total Pages: 37

ISBN-13: 9264366067

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This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene mutation. In vivo gene mutation tests, such as the Pig-a assay, are especially relevant for assessing mutagenicity because physiological factors, such as absorption of the test chemical from the site of exposure, distribution of the test chemical throughout the test system via systemic circulation, and in vivo metabolism and DNA repair processes, all contribute to the mutagenic responses.

Essentials of Pharmatoxicology in Drug Research, Volume 1
Essentials of Pharmatoxicology in Drug Research, Volume 1

Author: Rakesh Kumar Tekade

Publisher: Elsevier

Published: 2023-03-23

Total Pages: 754

ISBN-13: 044315841X

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Toxicity and Toxicodynamics, Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on the essentials of toxicology, risk assessment and the mechanisms. Topics discussed include the types of cellular responses to chemical toxicants, mechanisms of drug toxicity, and their relevance to pharmaceutical product development. The book examines omics and computer-aided technologies for mechanistic and predictive toxicology and covers state-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, as well as the role of regulatory agencies in toxicity studies. In addition, there is also discussion on clinical interventions such as pharmacotherapy and managed care strategies for acute poisoning. This volume is a valuable resource to those learning more about the drug development process related to toxicology and those who want to get an update on newer concepts on the toxicology aspect of drug research. - Examines toxicological risk assessment in drug research - Discusses toxicity mechanisms - Covers risk assessment and the use of omics and computational technologies in mechanistic and predictive toxicology - Offers clinical interventions and managed care as a result of toxic injury and acute poisoning

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 474: Mammalian Erythrocyte Micronucleus Test

Author: OECD

Publisher: OECD Publishing

Published: 2016-07-29

Total Pages: 21

ISBN-13: 9264264760

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The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood cells of animals, usually rodents (mice or rats).

Genetic Toxicology
Genetic Toxicology

Author: Albert P. Li

Publisher: CRC Press

Published: 1991-03-27

Total Pages: 508

ISBN-13: 9780849388156

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Genetic Toxicology is a comprehensive book covering the historical perspective of genetic toxicology; basic mechanisms of mutations and chromosomal effects; health consequences of genetic damage, including cancer and inheritable mutations; properties of physical, chemical, and biological mutagens; risk assessment of human exposure to genotoxicants; and the current position of some government regulatory agencies in the United States on the issues of genetic toxicology. The book will be a useful reference for students and researchers in toxicology, genetics, cancer biology, and medicine who are interested in the basic and applied principles of genetic toxicology. It will also benefit industrial toxicologists, products registration specialists, and government regulatory specialists with responsibility for the safety evaluation of industrial and environmental agents.

Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances
Some Chemicals that Cause Tumours of the Kidney Or Urinary Bladder in Rodents and Some Other Substances

Author: IARC Working Group on the Evaluation of Carcinogenic Risks to Humans

Publisher: World Health Organization

Published: 1999

Total Pages: 696

ISBN-13:

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Allyl isothiocyanate; ortho-Anisidine; Atrazine; Butyl benzyl phthalate; Chloroform; Chlorothalonil;Cyclamates;Dichlorobenzenes;Hexachlorobutadiene; Hexachloroethane; d-Limonene; Melamine; Methyl tert-butyl ether; Nitrilotriaceticacid andits salts;Paracetamol; ortho-Phenylphenol and its sodium salt; Potassium bromate ;Quercetin; Saccharin and its salts;Simazine

Guidelines for Canadian Drinking Water Quality
Guidelines for Canadian Drinking Water Quality

Author:

Publisher:

Published: 2023

Total Pages: 0

ISBN-13: 9780660460239

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"Malathion is a registered insecticide and acaricide used on a wide variety of sites including agricultural and non-agricultural sites. In 2018 (the most recent year for which data are available), over 25 000 kg of malathion was sold in Canada. Malathion may be released into surface water or soil as runoff from the application site. Malathion is not usually found in drinking water sources in Canada. Low levels of malathion have been found in several Canadian provinces. The maximum reported concentrations are well below the MAC. Malathion is rarely detected in foods"--Executive summary.

Soil Ecotoxicology
Soil Ecotoxicology

Author: Joseph Tarradellas

Publisher: CRC Press

Published: 1996-12-23

Total Pages: 406

ISBN-13: 9781566701341

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Soils are receptacles for a wide range of hazardous chemicals generated by human activities. Whether or not this contamination is deliberate, accurate toxicity assessments are important for health and economic reasons. Soil Ecotoxicology discusses the sources, fate, and transport of hazardous chemicals in soils. The fate (biodegradation and modeling) and the potential impacts of pesticides on soil ecosystems are emphasized, and methodologies for performing toxicity assessments are provided.

Nutritional Antioxidant Therapies: Treatments and Perspectives
Nutritional Antioxidant Therapies: Treatments and Perspectives

Author: Kaïs Hussain Al-Gubory

Publisher: Springer

Published: 2018-03-10

Total Pages: 572

ISBN-13: 3319676253

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This book offers a collection of expert reviews on the use of plant-based antioxidant therapies in disease prevention and treatment. Topics discussed include the uses of plant and nutritional antioxidants in the contexts of reproductive health and prenatal development, healthcare and aging, noncommunicable chronic diseases, and environmental pollution. The text is complemented by a wealth of color figures and summary tables.