OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Author: OECD

Publisher: OECD Publishing

Published: 2023-07-04

Total Pages: 28

ISBN-13: 9264203869

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The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the Classification and ...

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification
OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 492B: Reconstructed Human Cornea-like Epithelium (RHCE) Test Method for Eye Hazard Identification

Author: OECD

Publisher: OECD Publishing

Published: 2024-06-25

Total Pages: 35

ISBN-13: 9264542027

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This Test Guideline describes an in vitro procedure the identification on its own of chemicals (substances and mixtures) not requiring classification (No Cat), requiring classification for eye irritation (Cat 2) and requiring classification for serious eye damage (Cat 1) according to the UN GHS ocular hazard categories. It makes use of reconstructed human cornea-like epithelium (RhCE) which closely mimics the histological, morphological, biochemical and physiological properties of the human corneal epithelium.

A Practical Guide to Toxicology and Human Health Risk Assessment
A Practical Guide to Toxicology and Human Health Risk Assessment

Author: Laura Robinson

Publisher: John Wiley & Sons

Published: 2018-11-20

Total Pages: 402

ISBN-13: 1118882024

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Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.

Cosmetic Formulation
Cosmetic Formulation

Author: Heather A.E. Benson

Publisher: CRC Press

Published: 2019-04-05

Total Pages: 571

ISBN-13: 0429529082

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Cosmetics are the most widely applied products to the skin and include creams, lotions, gels, and sprays. Their formulation, design, and manufacturing ranges from large cosmetic houses to small private companies. This book covers the current science in the formulations of cosmetics applied to the skin. It includes basic formulation, skin science, advanced formulation, and cosmetic product development, including both descriptive and mechanistic content with an emphasis on practical aspects.

Globally Harmonized System of Classification and Labelling of Chemicals (GHS).
Globally Harmonized System of Classification and Labelling of Chemicals (GHS).

Author:

Publisher: Columbia Books. Incorporated

Published: 2015

Total Pages: 532

ISBN-13:

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The Globally Harmonized System of Classification and Labelling of Chemicals (GHS) addresses classification and labelling of chemicals by types of hazards. It provides the basis for worldwide harmonization of rules and regulations on chemicals and aims at enhancing the protection of human health and the environment during their handling, transport and use by ensuring that the information about their physical, health and environmental hazards is available. The sixth revised edition includes, inter alia, a new hazard class for desensitized explosives and a new hazard category for pyrophoric gases; miscellaneous amendments intended to further clarify the criteria for some hazard classes (explosives, specific target organ toxicity following single exposure, aspiration hazard, and hazardous to the aquatic environment) and to complement the information to be included in section 9 of the Safety Data Sheet; revised and further rationalized precautionary statements; and an example of labelling of a small packaging in Annex 7.

Organotypic Models in Drug Development
Organotypic Models in Drug Development

Author: Monika Schäfer-Korting

Publisher: Springer Nature

Published: 2021-03-25

Total Pages: 325

ISBN-13: 3030700631

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This book provides latest findings in organotypic models in drug development and provides the scientific resonance needed in an emerging field of research in disciplines, such as molecular medicine, physiology, and pathophysiology. Today the research on human-based test systems has gained major interest and funding in the EU and the US has increased over the last years. Moreover, so-called 3R (reduce, replace, refine animal experiments) centres have been established worldwide.