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Author: OECD
Publisher: OECD Publishing
Published: 2000-01-21
Total Pages: 16
ISBN-13: 9264070206
DOWNLOAD EBOOKThis Test Guideline is designed to assess the effects of prolonged exposure to chemicals on the growth of juvenile fish. Juvenile fish in exponential growth phase are placed, after being weighed, in test chambers and are normally exposed to five ...
Author: OECD
Publisher: OECD Publishing
Published: 2011-07-28
Total Pages: 44
ISBN-13: 9264122362
DOWNLOAD EBOOKThis Test Guideline describes an assay that assesses early life-stage effects and potential adverse consequences of putative endocrine disrupting chemicals (e.g. oestrogens, androgens and steroidogenesis inhibitors) on fish sexual development. In ...
Author: OECD
Publisher: OECD Publishing
Published: 2012-10-02
Total Pages: 72
ISBN-13: 9264185291
DOWNLOAD EBOOKThis Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...
Author: OECD
Publisher: OECD Publishing
Published: 2014-09-03
Total Pages: 174
ISBN-13: 9264221433
DOWNLOAD EBOOKThis document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Author: OECD
Publisher: OECD Publishing
Published: 2004-10-07
Total Pages: 244
ISBN-13: 9264017984
DOWNLOAD EBOOKThe OECD Guidelines for the Testing of Chemicals are a collection of internationally agreed methods for testing the safety of chemicals and chemical preparations, including pesticides and industrial chemicals. This 2005 update contains 11 new and 3 revised guidelines.
Author: Wael Mohamed
Publisher: CRC Press
Published: 2024-10-04
Total Pages: 315
ISBN-13: 1040115896
DOWNLOAD EBOOKThe increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the zebrafish (ZF) as a model for studying Parkinson’s disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource. Key Features Provides a comparative perspective of the zebrafish–Parkinson’s disease model Highlights the restrictions of available medicines Describes biochemical and histopathological characteristics, advantages, and disadvantages of this model Emphasizes distinct facets of histopathology Presents advances and developments of the future potential perspectives
Author: Zhengtao Liu
Publisher: Springer
Published: 2015-09-28
Total Pages: 175
ISBN-13: 9401772703
DOWNLOAD EBOOKThe book mainly introduces readers to the development and current status of water quality criteria (WQC) in China and other countries or areas, and proposes a minimum toxicity data requirement (MTDR; i.e., six species from three phyla) as the principle metric for deriving WQC in China. Further, ten model species from 4 different phyla are recommended as domestic test species, and the methodologies for deriving aquatic life criteria, sediment criteria, ecocriteria and nutrient criteria in China are also described in detail. In order to demonstrate the methods, several representative chemical pollutants and aquatic environments are highlighted as examples. The book provides important references for future WQC-related research in China, which will make it of great interest to researchers and graduate students in the fields of environmental science, ecology and aquatic science etc.
Author: Gowhar Hamid Dar
Publisher: CRC Press
Published: 2021-12-22
Total Pages: 389
ISBN-13: 1000291138
DOWNLOAD EBOOKThis new volume addresses the environmental impacts of pollution on freshwater aquatic ecosystems and presents sustainable management and remediation practices and advanced technology help to address the different types of pollutants. Freshwater Pollution and Aquatic Ecosystems: Environmental Impact and Sustainable Management considers the need for sustainable, efficient, and cost-effective tools and technologies to assess, monitor, and properly manage the increasing issues of aquatic pollution. It provides detailed accounts of the phenomena and mechanisms related to aquatic pollution and highlights the problems and threats associated with pollution contamination in freshwater. It provides useful insight into the sustainable and advanced pollution remediation technology adopted by different countries for the monitoring, assessment, and sustainable management of pollution. The chapters in the volume evaluate the sources of harmful pollutants, which include industrial effluents, sewage, and runoff from agricultural industries, which result in toxic microbes, organic waste, oils, and high load of nutrients. Unsustainable management practices of domestic sewage and indiscriminate use of chemical pesticides lead to the technological disturbance of aquatic biota. In addition to harming aquatic biota, these pollutants find their way into the human body through inhalation, ingestion, or absorption and finally tend to bio-accumulate in trophic levels of the food chain, which poses a major risk to human beings. This book will be a valuable resource for ecologists, environmentalists, scientists, and many others for their work in understanding and management of aquatic pollutants in freshwater biospheres.
Author: Saravana Babu Chidambaram
Publisher: Springer Nature
Published: 2022-02-11
Total Pages: 205
ISBN-13: 9811660921
DOWNLOAD EBOOKThis book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
Author: Carey N. Pope
Publisher: Academic Press
Published: 2020-02-18
Total Pages: 646
ISBN-13: 0128136030
DOWNLOAD EBOOKAn Introduction to Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology, from "simple molecular systems, to complex human communities, with expertise from a spectrum of interacting disciplines. Chapters are written by specialists within a given subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are also included. The book allows students to concurrently learn concepts in both biomedical and environmental toxicology fields, thus better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology. - Covers major topics and newer areas in toxicology, including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity - Includes a variety of perspectives to give a complete understanding of toxicology - Written by specialists within each subject area, e.g., a chemical engineer, to ensure concepts are clearly explained
