Non-Coding RNAs in Reproductive Biology
Author: Linjun Hong
Publisher: Frontiers Media SA
Published: 2021-08-25
Total Pages: 126
ISBN-13: 2889712273
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Non-coding RNA and the Reproductive System
Author: Dagmar Wilhelm
Publisher: Springer
Published: 2015-12-11
Total Pages: 201
ISBN-13: 940177417X
DOWNLOAD EBOOKThis book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.
Non-Coding RNAs
Author: Jan Barciszewski
Publisher: Springer Science & Business Media
Published: 2003-08-31
Total Pages: 302
ISBN-13: 9780306478352
DOWNLOAD EBOOKGeneral inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: I. protein-coding mRNAs, II. non-coding housekeeping and III. regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Non-coding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term non-coding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of Non-Coding RNAs and their relationship to Molecular Biology and Molecular Biology.
Long Noncoding RNAs in Plants
Author: Santosh Kumar Upadhyay
Publisher: Academic Press
Published: 2020-11-13
Total Pages: 392
ISBN-13: 0128214635
DOWNLOAD EBOOKThe growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. - Includes the latest advances and research in long noncoding RNAs in plants - Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops - Focuses on the application and uses of long noncoding RNAs
Non-Coding RNAs
Author: Lütfi Tutar
Publisher: BoD – Books on Demand
Published: 2020-03-04
Total Pages: 150
ISBN-13: 1789856558
DOWNLOAD EBOOKNoncoding RNAs (ncRNAs) are an attractive research field in the RNA world. ncRNAs play important roles in regulating gene expression in animals, plants, and various human diseases. It is clear that current and further research on ncRNAs will change our knowledge of the nature of genome composition by editing previous dogmas. This book provides an overview of current knowledge on ncRNA research by dealing with miRNA and ncRNA-related human diseases, plant miRNA markers, and the roles of lncRNAs in cancer and epigenetics.
Small Non-Coding RNAs
Author: Mathieu Rederstorff
Publisher: Humana
Published: 2016-10-05
Total Pages: 0
ISBN-13: 9781493949038
DOWNLOAD EBOOKThis volume contains state-of-the-art methods tackling all aspects of small non-coding RNAs biology. Small Non-Coding RNAs: Methods and Protocols guides readers through customized dedicated protocols and technologies that will be of valuable help to all those willing to contribute deciphering the numerous functions of small non-coding RNAs. Written in the highly successful Methods of Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubles troubleshooting and avoiding known pitfalls. Instructive and practical, Small Non-Coding RNAs: Methods and Protocols reaches out to biochemists, cellular and molecular biologists already working in the field of RNA biology and to those just starting to study small non-coding RNAs.
Regulatory Non-Coding RNAs
Author: Gordon G. Carmichael
Publisher: Humana Press
Published: 2014-09-20
Total Pages: 181
ISBN-13: 9781493913701
DOWNLOAD EBOOKRegulatory Non-Coding RNAs: Methods and Protocols offers a collection of methods for those interested in the discovery, localization, and functional analysis of these non-coding transcripts that have the potential and ability to orchestrate and control gene expression. After a review of the field, this detailed volume continues with methods useful for the study of siRNAs, microRNAs and their targets, techniques concerned with long non-coding RNAs, as well as studies of the critical parameters of functional non-coding RNA protein-RNA interactions and the environment in which they act. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips for troubleshooting and avoiding known pitfalls. Dependable and easy to use, Regulatory Non-Coding RNAs: Methods and Protocols provides a current, state-of-the-art collection of methods and approaches that will be of value to researchers in this expanding and fascinating field.
Non Coding RNA Biology
Author: Boston Carter
Publisher: Callisto Reference
Published: 2023-09-26
Total Pages: 0
ISBN-13: 9781641167611
DOWNLOAD EBOOKNon-coding RNAs (ncRNAs) are RNA molecules that are not translated into proteins. They are divided into two categories, namely, housekeeping ncRNAs and regulatory ncRNAs. The main function of the ncRNAs is to maintain the normal cell functionalities. Small RNAs, ribosomal RNAs (rRNAs), long ncRNAs and transfer RNAs are some types of non-coding RNAs, which are abundant and functionally significant. Numerous types of small and long non-coding RNAs are considered important regulators of gene expression in a variety of processes, which range from embryonic development to innate immunity. This promotion of gene expression is done by a special ncRNA named enhancer RNA, which is transcribed from the enhancer region of the gene. The human genome is encoded with thousands of small and long RNA transcripts that do not code for proteins. This book explores all the important aspects of regulatory non-coding RNAs. It will prove to be immensely beneficial to students and researchers studying this topic.
Long Non-coding RNA
Author: Antonin Morillon
Publisher: Elsevier
Published: 2018-02-01
Total Pages: 192
ISBN-13: 0081023553
DOWNLOAD EBOOKThe dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function. This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology. Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms. - This book offers a large review about the long non-coding RNA - It presents the broad functional diversities of those molecules - It presents pioneer works from the field - Provides a comprehensive review of the field - Presents fundamental and therapeutic interests
Non-Protein Coding RNAs
Author: Nils Walter
Publisher: Springer Science & Business Media
Published: 2008-11-18
Total Pages: 400
ISBN-13: 3540708405
DOWNLOAD EBOOKThe 2006 Nobel Prize in Physiology or Medicine was awarded to the discoverers of RNA interference, Andrew Fire and Craig Mello. This prize, which follows “RNA” Nobels for splicing and RNA catalysis, highlights just one class of recently discovered non-protein coding RNAs. Remarkably, non-coding RNAs are thought to outnumber protein coding genes in mammals by perhaps as much as four-fold. In fact, it appears that the complexity of an organism correlates with the fraction of its genome devoted to non-protein coding RNAs. Essential biological processes as diverse as cell differentiation, suppression of infecting viruses and parasitic tra- posons, higher-level organization of eukaryotic chromosomes, and gene expression are found to be largely directed by non-protein coding RNAs. Currently, bioinformatic, high-throughput sequencing, and biochemical approaches are identifying an increasing number of these RNAs. Unfortunately, our ability to characterize the molecular details of these RNAs is significantly lacking. The biophysical study of these RNAs is an emergent field that is unraveling the molecular underpinnings of how RNA fulfills its multitude of roles in sustaining cellular life. The resulting understanding of the physical and chemical processes at the molecular level is critical to our ability to harness RNA for use in biotechnology and human therapy, a prospect that has recently spawned a multi-billion dollar industry.
