The supplement to 'The NOC Trilogy'. Seen through the uncommon perspective of a British covert action MI6 intelligence officer as a one-man station overseas, who is occasionally operational in hostile environments for queen and country. See author's website: www.NicholasAnderson.info
Proteins are indispensable players in virtually all biological events. The functions of proteins are coordinated through intricate regulatory networks of transient protein-protein interactions (PPIs). To predict and/or study PPIs, a wide variety of techniques have been developed over the last several decades. Many in vitro and in vivo assays have been implemented to explore the mechanism of these ubiquitous interactions. However, despite significant advances in these experimental approaches, many limitations exist such as false-positives/false-negatives, difficulty in obtaining crystal structures of proteins, challenges in the detection of transient PPI, among others. To overcome these limitations, many computational approaches have been developed which are becoming increasingly widely used to facilitate the investigation of PPIs. This book has gathered an ensemble of experts in the field, in 22 chapters, which have been broadly categorized into Computational Approaches, Experimental Approaches, and Others.
Characterizes the toxicologic and adverse health effects for arsenic, which has been found in many sites targeted for long-term fed. cleanup activities. Contents: (1) The examination, summary, and interpretation of available toxicologic info. and epidemiologic evaluations on arsenic to ascertain the levels of significant human exposure for the substance and the associated chronic health effects; (2) A determination of whether adequate info. on the health effects of arsenic is available to determine levels of exposure that present a significant risk to human health of chronic health effects; and (3) Identification of toxicologic testing needed to identify the types or levels of exposure that may present significant risk of adverse health effects in humans. Illus.
New Challenges for Future Sustainability and Wellbeing is a collection of studies about sustainability and related challenges, such as income, wealth, the environment, education and regional equality that influence the pace of economic development and affects the well-being of people and organisations all over the world.
Drosophila--the scientist's favorite laboratory organism--is a key subject for studying genetics, development, and behavior. The second edition of this popular hands-on guide brings the methodology up-to-date, with contributions from the leading researchers in the field. Chapters include the elements of Drosophila biology and genetics; mutagenesis; transposons--gene tagging and mutagenesis; chromosome mechanics: the genetic manipulation of aneuploid stocks; enhancer traps; looking at embryos; immunolabelling of Drosophila; population and ecological genetics; behavior, learning, and memory; cell culture; and preparation of nucleic acids.