Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor
Nicotinoid Insecticides and the Nicotinic Acetylcholine Receptor

Author: I. Yamamoto

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 300

ISBN-13: 4431679332

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The nicotinoids are the most important new class of pesticides, joining the organophosphorus compounds, methylcarbamates, and pyrethroids as the major insecticides. Recently, imidacloprid and related nicotinoids have begun replacing organophosphorus and methylcarbamate compounds as insecticides to control insect pests on major crops. Nicotinoids act on the nicotinic acetylcholine receptor, as does naturally occurring nicotine, but with remarkable effectiveness against insects while being safe for mammals; they are quickly degraded and do not persist in the environment. This volume describes the relationship of nicotinoids to botanical insecticidal alkaloids, their discovery and development as insecticides, and the prospects for their expanded use and for the development of resistance. This book is the first to provide concise, comprehensive information on nicotinoids, their chemistry, mode of action, metabolism, and application in agriculture.

Nicotinic Receptors
Nicotinic Receptors

Author: Robin A.J. Lester

Publisher: Springer

Published: 2014-11-11

Total Pages: 468

ISBN-13: 1493911678

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A comprehensive overview of nicotinic receptors that addresses their history from crystal structure to behavior as well as their implications in disease and potential as therapeutic targets. It includes background information on all subtypes of nicotinic receptors, the most recent information on the distribution throughout the nervous system and discussion of their implications in learning and memory, addiction and neurological and psychiatric disease such as Alzheimer's and Parkinson's. Takes advantage of several recent developments in the fields of optogenetics, viral expression and gene analysis to focus on current knowledge on the functional aspects of nicotinic receptors.

Insect Nicotinic Acetylcholine Receptors
Insect Nicotinic Acetylcholine Receptors

Author: Steeve Hervé Thany

Publisher: Springer Science & Business Media

Published: 2011-01-11

Total Pages: 127

ISBN-13: 1441964452

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The aim of this book is to summarize our understanding on the insect nicotinic acetylcholine receptors. This area of research received great impetus from the identification of the first subunit sequences to be used as neonicotinoid insecticide target sites. Although a book of this nature can provide the details only of commonly published results, it is hoped that it may provide a useful guide to the newcomer to the field as well as to point out some of the future challenges. For example, we need to determine the precise subunit nomenclature of insect nicotinic receptors. This nomenclature varies amongst species and this led to some of the early confusion that persists. We need to be precise in identifying the subunit composition of native insect nicotinic receptor subtypes, their functional properties and physiological roles.

Cellular and Molecular Neurophysiology
Cellular and Molecular Neurophysiology

Author: Constance Hammond

Publisher: Academic Press

Published: 2014-12-30

Total Pages: 444

ISBN-13: 0123973228

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Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. - 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations - Fifteen appendices describing neurobiological techniques are interspersed in the text

Neuronal Nicotinic Receptors
Neuronal Nicotinic Receptors

Author: F. Clementi

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 837

ISBN-13: 3642570798

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Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.

Jasper's Basic Mechanisms of the Epilepsies
Jasper's Basic Mechanisms of the Epilepsies

Author: Jeffrey Noebels

Publisher: OUP USA

Published: 2012-06-29

Total Pages: 1258

ISBN-13: 0199746540

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Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.

Conn's Translational Neuroscience
Conn's Translational Neuroscience

Author: P. Michael Conn

Publisher: Academic Press

Published: 2016-09-28

Total Pages: 778

ISBN-13: 0128025964

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Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment

Neuroscience of Nicotine
Neuroscience of Nicotine

Author: Victor R Preedy

Publisher: Academic Press

Published: 2019-03-20

Total Pages: 568

ISBN-13: 0128130369

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Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse. With an estimated one billion individuals worldwide classified as tobacco users—and tobacco use often being synonymous with nicotine addiction—nicotine is one of the world's most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process. - Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function - Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse - Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects

Biochemical Sites of Insecticide Action and Resistance
Biochemical Sites of Insecticide Action and Resistance

Author: Isaac Ishaaya

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 353

ISBN-13: 3642595499

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In recent years many of the conventional methods of insect control by broad spectrum synthetic chemicals have come under scrutiny because of their unde sirable effects on human health and the environment. In addition, some classes of pesticide chemistry, which generated resistance problems and severely affected the environment, are no longer used. It is against this background that the authors of this book present up-to-date findings-relating to biochemical sites that can serve as targets for developing insecticides with selective prop erties, and as the basis for the elucidation of resistance mechanisms and countermeasures. The book consists of eight chapters relating to biochemical targets for insec ticide action and seven chapters relating to biochemical modes of resistance and countermeasures. The authors of the chapters are world leaders in pesti cide chemistry, biochemical modes of action and mechanisms of resistance. Biochemical sites such as chitin formation, juvenile hormone and ecdysone receptors, acetylcholine and GABA receptors, ion channels, and neuropeptides are potential targets for insecticide action. The progress made in recent years in molecular biology (presented in depth in this volume) has led to the iden tification of genes that confer mechanisms of resistance, such as increased detoxification, decreased penetration and insensitive target sites. A combina tion of factors can lead to potentiation of the resistance level. Classifications of these mechanisms are termed gene amplification, changes in structural genes, and modification of gene expression.

Understanding Drug Action
Understanding Drug Action

Author: Peter J. Rice

Publisher: Amer Pharmacists Assn

Published: 2013-11-11

Total Pages: 335

ISBN-13: 9781582121123

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Understanding Drug Action: An Introduction to Pharmacology provides readers with a survey of the scientific understanding of drug action. This readable introduction to pharmacology is simple enough to be understood without having to take a class to follow the material, but can also be used to complement a course in pharmacology. The approach to pharmacology is at a basic scientific level to build a framework of how drugs work supplemented with information on some representative drugs that are used clinically. Each chapter includes review questions and many chapters include tables of important drugs with brand and generic names.