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Author: Reginald B. Garvey
Publisher: Nova Publishers
Published: 2007
Total Pages: 202
ISBN-13: 9781600214011
DOWNLOAD EBOOKThis book presents research on cell growth and the ageing process. Emphasis is given to implications for cancer therapy, abnormal mitosis and aberrant nuclear morphology, neoplastic transformations, negative charges on various malignant cell types.
Author: Trygve O. Tollefsbol
Publisher: Springer Science & Business Media
Published: 2008-02-03
Total Pages: 844
ISBN-13: 1597453617
DOWNLOAD EBOOKThis book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.
Author: J. Robin Harris
Publisher: Springer
Published: 2019-02-18
Total Pages: 526
ISBN-13: 9811328358
DOWNLOAD EBOOKThis new volume in the Subcellular Biochemistry series will focus on the biochemistry and cellular biology of aging processes in human cells. The chapters will be written by experts in their respective fields and will focus on a number of the current key areas of research in subcellular aging research. Main topics for discussion are mitochondrial aging, protein homeostasis and aging and the genetic processes that are involved in aging. There will also be chapters that are dedicated to the study of the roles of a variety of vitamins and minerals on aging and a number of other external factors (microbiological, ROS, inflammation, nutrition). This book will provide the reader with a state of the art overview of the subcellular aging field. This book will be published in cooperation with a second volume that will discuss the translation of the cell biology of aging to a more clinical setting and it is hoped that the combination of these two volumes will bring a deeper understanding of the links between the cell and the body during aging.
Author: Nikki J. Holbrook
Publisher: John Wiley & Sons
Published: 1995-12-20
Total Pages: 344
ISBN-13: 9780471121237
DOWNLOAD EBOOKCellular AGING AND CELL DEATH Edited by Nikki J. Holbrook, George R. Martin, and Richard A.Lockshin Cellular Aging and Cell Death provides a thorough understanding ofthe mechanisms responsible for cellular aging, covering the recentresearch on programmed cell death and senescence, and describingtheir role in the control of cell proliferation and the agingprocess. This one-of-a-kind book is the first to combine the twohottest research areas of cell biology into one comprehensivetext. Leading experts contribute to give readers an authoritativeoverview of the distinct fields of cellular aging and programmedcell death, as well as to demonstrate how both fields are criticalto understanding the aging process. They address the large andgrowing interest in apoptosis, especially with regard to themolecular signals that induce and regulate programmed cell death,and the role of apoptosis in a variety of age-associated diseasesand disabilities. Throughout the book, a strong emphasis is placedon the interrelationship of the molecular, cellular, andphysiological aspects of senescence. Individual chapters discuss such topics as the role and regulationof apoptosis in development, the potential impact of cell death onsuch postmitotic tissues as nerve and muscle, and suggest thatprogrammed cell death plays an important role in both pathologicaland nonpathological aspects of aging, including neurodegenerativediseases. One important chapter focuses on the most recent research involvingthe study of telomeres, whose reduction in length with age and celldivision may underlie cellular senescence. The subject of neuronalcell death is also put into the perspective of aging. Cellular Aging and Cell Death bridges the rapidly growing fields ofcellular aging and programmed cell death. This thorough, yetconcise book will be of particular interest to graduate studentsand researchers within the fields of cell and developmentalbiology, neurobiology, immunology, and physiology. Physicians andmedical students involved in the fields of gerontology andpathology will also find this an informative reference.
Author: Roman Strakos̆
Publisher:
Published: 2018
Total Pages: 181
ISBN-13: 9781536136272
DOWNLOAD EBOOKNew Research on Cell Aging and Death reviews previous literature to describe the main behavioral and biochemical characteristics of the SAMP8 mouse model, discussing its main advantages as well as potential weaknesses to model age-related diseases. The subsequent chapter discusses the effect of the mechanism of cell death of neutrophil granulocytes on the realization of the inflammatory process. Neutrophil granulocytes play a central role in the innate nonspecific defense response of the human organism. In addition, neutrophils infiltrate secondary lymphoid organs where they regulate the development of adaptive immunity. Later, the authors suggest that in C. albicans, apoptotic mechanisms are valuable as major strategies with several characteristics such as phosphatidylserine exposure, DNA fragmentation, and activation of metacaspase. Studying antifungal agents with varying mechanisms of action can be effective in appropriately treating potentially fatal candidiasis. In one study, the authors evaluated the effects of natural and chemical compounds on promoter activities of several human DNA repair-associated genes in HeLa S3 cells. . The results indicated that naturally occurring compounds, for example, trans-resveratrol, upregulate TP53 promoter activity. Sustaining an appropriate level of genes encoding DNA repair factors is thought to be necessary for cell survival by preventing the accumulation of DNA mismatches and epigenetic alterations. The concluding review focuses on the effects of aging on adult neurogenesis, a process of producing new neurons from neural stem cells and neural progenitor cells in the neocortex, comparing the dentate gyrus and subventricular zone.
Author: Michael B. Fossel M.D.
Publisher: Oxford University Press
Published: 2004-06-10
Total Pages: 504
ISBN-13: 0190286261
DOWNLOAD EBOOKCells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.
Author: Paola S. Timiras
Publisher: CRC Press
Published: 2007-08-16
Total Pages: 426
ISBN-13: 1420007092
DOWNLOAD EBOOKExtensively revised and updated to reflect the current state of knowledge in the study of aging, this Fourth Edition offers a complete profile of the aging process at all levels, from molecules and cells to demography and evolution. Written by international experts in current basic and clinical aging research, this text includes aspects of individual, comparative, and differential aging, and discussions of theories and mechanisms of aging. This invaluable reference illustrates how bodily systems, organs, and functions are affected with aging, describes how genetic and environmental factors influence age-related changes, and addresses some of the clinical consequences of these changes for health and longevity. Well illustrated, with numerous tables and graphs, this book presents up-to-date information from internationally renowned experts in various bio-medical fields.
Author: A.I. Yashin
Publisher: Karger Medical and Scientific Publishers
Published: 2014-10-14
Total Pages: 208
ISBN-13: 3318027308
DOWNLOAD EBOOKAging is a major risk factor for chronic diseases, which in turn can provide information about the aging of a biological system. This publication serves as an introduction to systems biology and its application to biological aging. Key pathways and processes that impinge on aging are reviewed, and how they contribute to health and disease during aging is discussed. The evolution of this situation is analyzed, and the consequences for the study of genetic effects on aging are presented. Epigenetic programming of aging, as a continuation of development, creates an interface between the genome and the environment. New research into the gut microbiome describes how this interface may operate in practice with marked consequences for a variety of disorders. This analysis is bolstered by a view of the aging organism as a whole, with conclusions about the mechanisms underlying resilience of the organism to change, and is expanded with a discussion of circadian rhythms in aging. Finally, the book presents an outlook for the development of interventions to delay or to reverse the features of aging. The publication is recommended to students, researchers as well as professionals dealing with public health and public policy related to an aging society.
Author: Tom Kirkwood Professor of Biological Gerontology University of Manchester
Publisher: Oxford University Press, USA
Published: 1999-06-23
Total Pages: 290
ISBN-13: 019802939X
DOWNLOAD EBOOKAs recent articles about "the graying of America" suggest, a demographic revolution is well underway. The number of people living into extreme old age is increasing dramatically. By the year 2050 one in five of the world's population, including the developing countries, will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood unfolds some of the deepest mysteries of medical science while demolishing some of the most persistent misconceptions. He overturns the almost universally held belief that aging is either necessary or inevitable--it isn't--and debunks the idea that there exists a "death gene" that evolved to inhibit population growth. Instead, Kirkwood shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. Expanding his thesis of the "disposable soma," developed over twenty years of research, Kirkwood makes sense of the evolution of aging, explains how aging occurs, and answers fundamental questions like why women live longer than men. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.
Author: Alvaro Macieira-Coelho
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 198
ISBN-13: 3642189946
DOWNLOAD EBOOKThe survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.
