Nematodes as Model Organisms

Nematodes as Model Organisms

Author: Itamar Glazer

Publisher: CABI

Published: 2022-05-16

Total Pages: 386

ISBN-13: 1789248795

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Nematodes are small multicellular organisms that have been used as biological models since the 1960s. For example, Caenorhabditis elegans is a free-living nematode worm, about 1mm in length, that lives in temperate soil environments. It is made up of about 1000 cells, and has a short life cycle of only two weeks. It was the first multicellular organism to have its whole genome sequenced. The book summarizes the importance of nematodes as model organisms in the fields of genetics, developmental biology, neurobiology, pharmacology, nutrition, ecology and parasitology. Of interest to a broad audience across a wide spectrum of disciplines, this book is useful for biologists working on comparative studies to investigate biological processes across organisms; medical scientists and pharmacologists for exploration of drugs and medicine (including the use of genome editing to eliminate diseases); ecologists considering nematodes as indicators for environment changes; and parasitologists for host-parasite interactions. Many other researchers can use this book as a benchmark for the broad implications of nematology research on other aspects of science.


C. Elegans II

C. Elegans II

Author: Donald L. Riddle

Publisher: Firefly Books

Published: 1997

Total Pages: 1252

ISBN-13: 9780879695323

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Defines the current status of research in the genetics, anatomy, and development of the nematode C. elegans, providing a detailed molecular explanation of how development is regulated and how the nervous system specifies varied aspects of behavior. Contains sections on the genome, development, neural networks and behavior, and life history and evolution. Appendices offer genetic nomenclature, a list of laboratory strain and allele designations, skeleton genetic maps, a list of characterized genes, a table of neurotransmitter assignments for specific neurons, and information on codon usage. Includes bandw photos. For researchers in worm studies, as well as the wider community of researchers in cell and molecular biology. Annotation copyrighted by Book News, Inc., Portland, OR


Scientific Frontiers in Developmental Toxicology and Risk Assessment

Scientific Frontiers in Developmental Toxicology and Risk Assessment

Author: National Research Council

Publisher: National Academies Press

Published: 2000-11-21

Total Pages: 347

ISBN-13: 0309171806

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Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.


Fluorescent Nanodiamonds

Fluorescent Nanodiamonds

Author: Huan-Cheng Chang

Publisher: John Wiley & Sons

Published: 2018-11-12

Total Pages: 294

ISBN-13: 1119477085

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The most comprehensive reference on fluorescent nanodiamond physical and chemical properties and contemporary applications Fluorescent nanodiamonds (FNDs) have drawn a great deal of attention over the past several years, and their applications and development potential are proving to be manifold and vast. The first and only book of its kind, Fluorescent Nanodiamonds is a comprehensive guide to the basic science and technical information needed to fully understand the fundamentals of FNDs and their potential applications across an array of domains. In demonstrating the importance of FNDs in biological applications, the authors bring together all relevant chemistry, physics, materials science and biology. Nanodiamonds are produced by powerful cataclysmic events such as explosions, volcanic eruptions and meteorite impacts. They also can be created in the lab by high-pressure high-temperature treatment of graphite or detonating an explosive in a reactor vessel. A single imperfection can give a nanodiamond a specific, isolated color center which allows it to function as a single, trapped atom. Much smaller than the thickness of a human hair, a nanodiamond can have a huge surface area that allows it to bond with a variety of other materials. Because of their non-toxicity, nanodiamonds may be useful in biomedical applications, such as drug delivery and gene therapy. The most comprehensive reference on a topic of rapidly increasing interest among academic and industrial researchers across an array of fields Includes numerous case studies and practical examples from many areas of research and industrial applications, as well as fascinating and instructive historical perspectives Each chapter addresses, in-depth, a single integral topic including the fundamental properties, synthesis, mechanisms and functionalisation of FNDs The first book published by the key patent holder with his research group in the field of FNDs Fluorescent Nanodiamonds is an important working resource for a broad range of scientists and engineers in industry and academia. It will also be a welcome reference for instructors in chemistry, physics, materials science, biology and related fields.


Pristionchus pacificus

Pristionchus pacificus

Author:

Publisher: BRILL

Published: 2015-03-20

Total Pages: 438

ISBN-13: 9004260307

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This edited volume on the nematode model Pristionchus pacificus describes an integrative approach to evolutionary biology. It aims for a merger of evolutionary and comparative biology with mechanistic approaches based on genetics and molecular biology. Insight into the function of biological systems obtained from laboratory studies when complemented with ecology, natural variation and natural history of an organism, can provide detailed knowledge of the proximate and ultimate causations of species. Ralf J. Sommer developed P. pacificus as model system for integrative evolutionary biology with case studies in evo-devo and population genetics on La Réunion Island. Similarly, ecological interactions with scarab beetles revealed examples for the evolution of novelty at the morphological and behavioural level and their underlying molecular mechanisms. Contributors include Paul W. Sternberg, Ralf J. Sommer, Jagan Srinivasan, Christian Rödelsperger, Frank C. Schroeder, Robin M. Giblin-Davis, Natsumi Kanzaki, Matthias Herrmann, Angela McGaughran, Katy Morgan, Akira Ogawa, Federico D. Brown, Ray E. Hong, Robbie Rae, Amit Sinha, David Rudel, and Erik J. Ragsdale.


Animal Evolution

Animal Evolution

Author: Claus Nielsen

Publisher: Oxford University Press on Demand

Published: 2012

Total Pages: 421

ISBN-13: 0199606021

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Using modern phylogenetic reasoning based on an extensive review of morphology, including ultrastructure, and embryology, each phylum is analysed to ascertain its monophyly and hence its ancestral characters.


Nematode Models of Development and Disease

Nematode Models of Development and Disease

Author:

Publisher: Academic Press

Published: 2021-05-13

Total Pages: 452

ISBN-13: 0128161787

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Nematode Models of Development and Disease, Volume 144 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters surrounding Transgenerational inheritance, Oscillatory expression and function, Concepts and functions of small RNA pathways in C. elegans, Exploring the nuclear lamina in health and pathology using C. elegans, Cellular Plasticity, Morphogenesis, Tubulogenesis, Organogenesis forces, Programmed cell fusion in development and homeostasis, One template, two outcomes: how does the sex-shared nervous system generate sex-specific behaviors?, Metabolic Cellular Coordination of Gene-Environment Interactions, and much more. Other chapters cover Chemical and physical cues and micro-evolution in early embryogenesis, Innate immunity, Sex and Death, Dendrites maturation, axonal growth and extracellular glycoproteins, Autophagocytosis, Spermatogenesis, and the developmental and physiological roles of phagocytosis in Caenorhabditis elegans. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Current Topics in Developmental Biology


Agrobiodiversity Conservation

Agrobiodiversity Conservation

Author: Nigel Maxted

Publisher: CABI

Published: 2012

Total Pages: 387

ISBN-13: 1845938518

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Based on the 2010 conference "Towards the establishment of genetic reserves for crop wild relatives and landraces in Europe", this book is the cutting edge discussion of agrobiodiversity conservation. By considering the benefits of understanding and preserving crop wild relatives and landraces, it encompasses issues as wide-ranging and topical as habitat protection, ecosystem health and food security. Focusing on Europe, but globally relevant, Agrobiodiversity Conservation is ideal for postgraduate students of conservation and environmental studies, conservation professionals, policy makers and researchers.