Nanostructured Biomaterials for Cranio-maxillofacial and Oral Applications examines the combined impact of materials science, biomedical and chemical engineering, and biology to provide enhanced biomaterials for applications in maxillo-facial rehabilitation and implantology. With a strong focus on a variety of material classes, it examines material processing and characterization techniques to decrease mechanical and biological failure in the human body. After an introduction to the field, the most commonly used materials for cranio-facial applications, including ceramics, polymers and glass ceramics are presented. The book then looks at nanostructured surfaces, functionally graded biomaterials and the manufacturing of nanostructured materials via 3-D printing. This book is a valuable resource for scientists, researchers and clinicians wishing to broaden their knowledge in this important and developing field. - Explores the techniques used to apply nanotechnology to biomaterials for cranio-maxillofacial and oral applications - Bridges the gap between fundamental materials science and medicine - Shows how nanostructured biomaterials respond when implanted in the human body
The majority of the global population is affected by repair or replacement of craniofacial structures caused by tooth decay or loss as well as major craniofacial defects, necessitating complex tissue augmentation or regeneration procedures. As a result of exciting developments and the increasing number of novel biomaterials and different clinical applications, it is extremely important to understand these biomaterials and their design. This publication integrates the application of biomaterials science and describes the recent advances, the role of cutting-edge biomaterials in engineering oral tissues, surface modification technologies, the emerging field of nanomaterials and clinical translation showing future directions in oral and craniomaxillofacial health care. Researchers active in dental, medical and biomaterials sciences, oral and maxillofacial surgeons, dentists, tissue engineers as well as materials scientists will find valuable information on the latest progress and novel approaches as will all those who are looking for better solutions to the problems associated with facial deformities.
This book provides a critical overview of the advances being made towards overcoming biological barriers through the contribution of nanosciences and nanotechnologies. Overcoming these barriers is of primary importance for solving the problems of many current drugs and vaccines and it is also especially relevant for the commercial exploitation of new therapeutic strategies i.e. gene and cellular therapies. Despite important information that has been covered in recently published books related to nanomedicine (mainly oriented to technologies and applications), there is still an important gap related to the relationship between the chemical properties of nanobiomaterials and their interaction with the biological environment. Thus, this comprehensive new book that is presented with a clear and organised structure dedicated to the different biological barriers relevant for drug delivery applications will focus on (i) mechanistic issues related to the interaction between drug delivery systems and biological barriers and (ii) the analysis of the critical factors determining the efficacy of nanobiomaterials for specific applications. Moreover, this field has become highly multidisciplinary over the last decade, leading to the development of new products, as well as to significant advances from the regulatory point of view. Moreover, this book will also provide an up-to-date view on the clinical relevance of nanomedicine and on its possible impact on global health.
Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine. This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine. - Classifies materials into three classes for comprehensive discussion - Discusses design techniques to create innovative nanostructured biomaterials - Looks at enabling technologies and strategies for emerging applications
This issue of Oral and Maxillofacial Surgery Clinics of North America focuses on Emerging Biomaterials in Oral and Maxillofacial Surgery, and is edited by Dr. Alan Herford. Articles will include: Basic Principles of Bioengineering and Regeneration; Soft Tissue Regeneration Incorporating 3D Biomimetic Scaffolds; Advances in Orofacial Stem Cells for Tissue Regeneration; Tissue Engineering for Vertical Ridge Reconstruction; Integrating Biomaterials in Trauma; Tissue Engineered Pre-vascularized Bone and Soft Tissue Flaps; Application of Biomaterials for Implant Therapy; Maxillofacial Defects and Use of Growth Factors; New Frontiers in Biomaterials; Soft Tissue Engineering; and much more!
- The first reference work ever published on nanostructured biomaterials and their applications. - A unique source of in-depth knowledge of recent advances in applications of nanostructured biomaterials. Most up-to-date emerging aspects of nanobiomaterials and their applications in the field of nanotechnology. - Contains 33 state-of-the-art chapters written by over 70 internationally renowned experts from 10 countries. - About 5,000 bibliographic citations and hundreds of illustrations, figures, tables, chemical structures and equations.
This book introduces readers to the structure and characteristics of nanomaterials and their applications in dentistry. With currently available implant materials, the clinical failure rate varies from a few percent to over 10 percent and new materials are clearly needed. Nanomaterials offer the promise of higher strength, better bonding, less toxicity, and enhanced cytocompatibility, leading to increased tissue regeneration. Mieczyslaw Jurczyk, director of the Institute of Materials Science and Engineering at the Poznan University of Technology in Poland, has drawn from work in his laboratory and elsewhere in Poland to show that nanomaterials have important biological applications including in the stomatognathic system consisting of mouth, jaws, and associated structures. The book is written from a materials science and medical point of view and has 13 chapters and about 400 pages. The book can be divided approximately into three sections: the first five chapters introduce nanobiomaterials, the next five chapters describe their dental applications, and the last chapters describe their biocompatibility. Chapter 3 is a compendium on metallic biomaterials such as stainless steel, cobalt alloys, and titanium alloys; bioactive, bioresorbable polymers; and composites and ceramic biomaterials. The "top-down" approach to producing nanomaterials such as high-energy ballmilling and severe plastic deformation, as well as Feynman’s "bottom-up technique" of building atom by atom, are discussed in the next chapter. Subsequent chapters discuss each material in depth and point out how new architectures and properties emerge at the nanoscale. Chapter 8 is devoted to shape-memory materials, which now include not only NiTi but also polymers and magnetic materials. In order to improve bonding, nanomaterials can be used to synthesize implants with surface roughness similar to that of natural tissues. Chapter 9 is devoted to different surface treatments for Ti-based nanomaterials, such as anodic oxidation to improve the bioactivity of titanium and improve the corrosion resistance of porous titanium and its alloys. The use of carbon in various forms—nanoparticles, nanofibers, nanotubes, and thin films—is discussed next with emphasis on the microstructure and properties of these materials, their implant applications, and their interaction with subcutaneous tissues. Nanomaterials can be used in preventive dentistry and therefore can reduce the amount of dental treatment that is necessary to maintain a healthy mouth as argued in chapter 11. In a subsequent chapter, the author explains osseointegration (direct bone-to-metal interface) from a biological point of view and early tissue response. The mechanism of the interaction between the implanted materials with the cellular protein in the tissues is described. The last chapter discusses the application of new nanostructured materials in permanent and bioresorbable implants, nanosurface dental implants, and nanostructured dental composite restorative materials. This book not only focuses on nanomaterials but also on nanoengineering to achieve the best results in dentistry. It is recommended to anyone interested in nanomaterials and their applications in dental science. People with a background in materials, chemistry, physics, and biology will benefit from it.
Biomaterials for Oral and Dental Tissue Engineering examines the combined impact of materials, advanced techniques and applications of engineered oral tissues. With a strong focus on hard and soft intraoral tissues, the book looks at how biomaterials can be manipulated and engineered to create functional oral tissue for use in restorative dentistry, periodontics, endodontics and prosthodontics. Covering the current knowledge of material production, evaluation, challenges, applications and future trends, this book is a valuable resource for materials scientists and researchers in academia and industry. The first set of chapters reviews a wide range of biomaterial classes for oral tissue engineering. Further topics include material characterization, modification, biocompatibility and biotoxicity. Part Two reviews strategies for biomaterial scaffold design, while chapters in parts three and four review soft and hard tissues. - Connects materials science with restorative dentistry - Focuses on the unique field of intraoral tissues - Highlights long-term biocompatibility and toxicity of biomaterials for engineered oral tissues
Nanobiomaterials: Nanostructured materials for biomedical applications covers an extensive range of topics related to the processing, characterization, modeling, and biomedical applications of nanostructured ceramics, polymers, metals, composites, self-assembled materials, and macromolecules. Novel approaches for bottom-up and top-down processing of nanostructured biomaterials are highlighted. In addition, innovative techniques for characterizing the in vitro behavior and in vivo behavior of nanostructured biomaterials are considered. Applications of nanostructured biomaterials in dentistry, drug delivery, medical diagnostics, surgery and tissue engineering are examined. - Provides a concise description of the materials and technologies used in the development of nanostructured biomaterials - Provides industrial researchers with an up-to-date and handy reference on current topics in the field of nanostructured biomaterials - Includes an integrated approach that is used to discuss both the biological and engineering aspects of nanostructured biomaterials
Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. - Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied - Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine - Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices
