Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes
Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes

Author: Wim E. Crusio

Publisher: Cambridge University Press

Published: 2013-04-25

Total Pages: 361

ISBN-13: 1107355575

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The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders
Behavioral Genetics of the Mouse: Volume 2, Genetic Mouse Models of Neurobehavioral Disorders

Author: Susanna Pietropaolo

Publisher: Cambridge University Press

Published: 2014-09-25

Total Pages: 471

ISBN-13: 131606140X

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The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders: from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

What's Wrong With My Mouse?
What's Wrong With My Mouse?

Author: Jacqueline N. Crawley

Publisher: John Wiley & Sons

Published: 2007-03-23

Total Pages: 540

ISBN-13: 0471471925

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Dr. Jacqueline N. Crawley, author of the First and Second Editions of What’s Wrong with My Mouse? Behavioral Phenotyping of Transgenic and Knockout Mice,continues to field calls and e-mails from molecular geneticists who ask: how do I run behavioral assays to find out what’s wrong with my mouse? Turn to What’s Wrong with My Mouse? to discover the wealth of mouse behavioral tasks and to get the guidance you need to select the best methods and necessary controls. Chapters are organized by behavioral domain, including measurements of general health, motor functions, sensory abilities, learning and memory, feeding and drinking, reproductive, social, emotional, and reward behaviors in mutant mice. Throughout the chapters, new behavioral tasks and new research discoveries have been added, bringing the Second Edition up to date with the latest science. In addition, the Second Edition includes two new chapters: "Neurodevelopment and Neurodegeneration" discusses mouse behavioral tasks relevant to neurodevelopmental diseases, such as mental retardation and autism, and to neurodegenerative diseases, such as Alzheimers, Parkinsons, Huntingtons, and amyotrophic lateral sclerosis. "Putting It All Together" recommends strategies for optimizing a battery of behavioral phenotyping tests to address your specific hypotheses about gene functions. The final chapter, "The Next Generation," examines new and emerging technologies. Throughout the book, the use of behavioral testing equipment is illustrated with photographs, diagrams, and representative data. Examples of behavioral tasks successfully applied to transgenic and knockout mouse models are provided, as well as references to the primary literature and step-by-step methods protocols. These features, along with a comprehensive index, listings of database and vendor websites, and an extensive list of references, make this book a valuable and practical resource for students and researchers.

I Moved Your Cheese
I Moved Your Cheese

Author: Deepak Malhotra

Publisher: Berrett-Koehler Publishers

Published: 2013-09-02

Total Pages: 70

ISBN-13: 1609940679

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The author of Negotiating the Impossible “tackles our assumptions about business and life with humor, zest, and wisdom in this delightful fable” (Daniel H. Pink, New York Times-bestselling author). If you were a mouse trapped in a maze and someone kept moving the cheese, what would you do? In a world where most mice dutifully accept their circumstances, ask no questions, and keep chasing the cheese, Deepak Malhotra tells an inspiring story about three unique and adventurous mice—Max, Big, and Zed—who refuse to accept their reality as given. I Moved Your Cheese reveals what is possible when we finally discard long-held and widely accepted assumptions about how we should live our lives. After all, achieving extraordinary success, personal or professional, has always depended on the ability to challenge assumptions, reshape the environment, and play by a different set of rules—our own. But rejecting deeply ingrained beliefs is not easy. As Zed explains, “You see, Max, the problem is not that the mouse is in the maze, but that the maze is in the mouse.” “Deepak Malhotra allows you to glimpse a world of your own making without the limits and barriers that others create.” —Stephen R. Covey, New York Times-bestselling author of The 7 Habits of Highly Effective People “A magnificent story with a powerful message. As someone who has encouraged scores of professionals into breaking through the maze and defining their own pursuits, I find this to be a gem of a book.” —Vinod Khosla, cofounder, former CEO and Chairman, Sun Microsystems, and founder, Khosla Ventures “This book’s message is both profound and durable. Malhotra has left the maze, and so can we.” —Foreword Reviews

Degenerative Disorders of the Brain
Degenerative Disorders of the Brain

Author: Darren Hocking

Publisher: Routledge

Published: 2019-04-05

Total Pages: 283

ISBN-13: 135120890X

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Covering a wide range of diverse age-related disorders, Degenerative Disorders of the Brain addresses disabilities that occur or have their roots in the later stages of life. The book brings together an internationally recognised group of contributors to discuss frontostriatal, fronto-cerebellar and other major brain systems and structures which control and direct normal behaviour, and which can fail during the aging process, as well as addressing behavioural, clinical, pathophysiological and technical aspects. Discussing the latest clinical and behavioural findings of disorders which are largely, though not necessarily entirely, age related, including Alzheimer’s disease and other dementias, Parkinson’s disease and related disorders, and Huntington’s disease, the book covers information vital to the understanding, diagnosis, and management of degenerative disorders of the brain. It also considers the role of epigenetics, neural plasticity, and environmental enrichment in neurodegenerative disorders alongside the role of ground-breaking intervention methods, including transcranial magnetic stimulation and deep brain stimulation. Degenerative Disorders of the Brain will be of great interest to, and use for, clinicians, researchers, students, lecturers, and affected individuals and their relatives.

Therapeutic Relevance and Mechanisms of Neuro-Immune Communication in Brain Injury
Therapeutic Relevance and Mechanisms of Neuro-Immune Communication in Brain Injury

Author: Zhang Pengyue

Publisher: Frontiers Media SA

Published: 2023-08-25

Total Pages: 132

ISBN-13: 2832532535

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The brain is a critical organ with neuro-immune communication. The nervous system and immune system evolved to provide regulation of physiological homeostasis and protect against threats. Neuro-immune communication is correlated with physiological functions of various tissues and organs, and the internal environment balance. In brain trauma, the neural network is destroyed and the neuro-immune communication process is impaired. However, the research on this process is insufficient and limited. A thorough clarification of the cellular and molecular mechanisms of neuro-immune communication in brain injury is an essential necessary endeavor in the search for new therapeutic targets for brain injury. This Research Topic is devoted to the cellular and molecular mechanisms of neuro-immune communication in brain injury and on the meaningful exploration of how the nervous system regulates the immune system to promote neurofunctional recovery after brain injury.

HIV-Associated Neurocognitive Disorders
HIV-Associated Neurocognitive Disorders

Author: Guoku Hu

Publisher: Elsevier

Published: 2024-02-21

Total Pages: 654

ISBN-13: 0323997457

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HIV-Associated Neurocognitive Disorders: Molecular and Cellular Mechanisms and Clinical Manifestations is a comprehensive volume on the field of HIV-Associated Neurocognitive Disorders (HAND) as well as its associated comorbidities. Covering clinical manifestations as well as molecular and cellular mechanisms, this book discusses available macaque and rodent animal models of HAND, epigenetic regulation, and signaling pathways underlying symptoms. Chapters also cover prevention and therapeutic strategies, as well as diagnosis and biomarkers associated with disease outcomes. This volume is appropriate for basic research and clinical investigators working in the area of HIV-1 infection. - Provides an in-depth exploration of the clinical manifestations of HAND and its comorbidities - Includes detailed assessments of the molecular and cellular mechanisms underlying HAND symptoms - Examines animal models for studying HAND, including macaque and rodent models - Presents insights into epigenetic regulation and signaling pathways implicated in HAND - Covers prevention, therapeutic strategies, and diagnostic approaches