Molecular Evolution on Rugged Landscapes

Molecular Evolution on Rugged Landscapes

Author: Alan S. Perelson

Publisher: CRC Press

Published: 2018-03-08

Total Pages: 328

ISBN-13: 042996742X

DOWNLOAD EBOOK

This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.


Molecular Evolution on Rugged Landscapes

Molecular Evolution on Rugged Landscapes

Author: Alan S. Perelson

Publisher: CRC Press

Published: 2018-03-08

Total Pages: 242

ISBN-13: 0429978502

DOWNLOAD EBOOK

This book lays out a number of the general issues concerning the structure of rugged fitness landscapes and examines both the history and the current status of experimental work on somatic mutation and the maturation of the immune response.


Biodefense in the Age of Synthetic Biology

Biodefense in the Age of Synthetic Biology

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2019-01-05

Total Pages: 189

ISBN-13: 0309465184

DOWNLOAD EBOOK

Scientific advances over the past several decades have accelerated the ability to engineer existing organisms and to potentially create novel ones not found in nature. Synthetic biology, which collectively refers to concepts, approaches, and tools that enable the modification or creation of biological organisms, is being pursued overwhelmingly for beneficial purposes ranging from reducing the burden of disease to improving agricultural yields to remediating pollution. Although the contributions synthetic biology can make in these and other areas hold great promise, it is also possible to imagine malicious uses that could threaten U.S. citizens and military personnel. Making informed decisions about how to address such concerns requires a realistic assessment of the capabilities that could be misused. Biodefense in the Age of Synthetic Biology explores and envisions potential misuses of synthetic biology. This report develops a framework to guide an assessment of the security concerns related to advances in synthetic biology, assesses the levels of concern warranted for such advances, and identifies options that could help mitigate those concerns.


Epistasis and the Evolutionary Process

Epistasis and the Evolutionary Process

Author: Jason B. Wolf

Publisher: Oxford University Press, USA

Published: 2000

Total Pages: 348

ISBN-13: 9780195128062

DOWNLOAD EBOOK

Over the last two decades, research into epistasis has seen explosive growth and has moved the focus of research in evolutionary genetics from a traditional additive approach. We now know the effects of genes are rarely independent, and to reach a fuller understanding of the process of evolution we need to look at gene interactions as well as gene-environment interactions. This book is an overview of non-additive evolutionary genetics, integrating all work to date on all levels of evolutionary investigation of the importance of epistasis in the evolutionary process in general. It includes a historical perspective on this emerging field, in-depth discussion of terminology, discussions of the effects of epistasis at several different levels of biological organization and combinations of theoretical and experimental approaches to analysis.


The Origins of Order

The Origins of Order

Author: Stuart A. Kauffman

Publisher: Oxford University Press

Published: 1993-06-10

Total Pages: 958

ISBN-13: 0199826676

DOWNLOAD EBOOK

Stuart Kauffman here presents a brilliant new paradigm for evolutionary biology, one that extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. The book drives to the heart of the exciting debate on the origins of life and maintenance of order in complex biological systems. It focuses on the concept of self-organization: the spontaneous emergence of order that is widely observed throughout nature Kauffman argues that self-organization plays an important role in the Darwinian process of natural selection. Yet until now no systematic effort has been made to incorporate the concept of self-organization into evolutionary theory. The construction requirements which permit complex systems to adapt are poorly understood, as is the extent to which selection itself can yield systems able to adapt more successfully. This book explores these themes. It shows how complex systems, contrary to expectations, can spontaneously exhibit stunning degrees of order, and how this order, in turn, is essential for understanding the emergence and development of life on Earth. Topics include the new biotechnology of applied molecular evolution, with its important implications for developing new drugs and vaccines; the balance between order and chaos observed in many naturally occurring systems; new insights concerning the predictive power of statistical mechanics in biology; and other major issues. Indeed, the approaches investigated here may prove to be the new center around which biological science itself will evolve. The work is written for all those interested in the cutting edge of research in the life sciences.


The Adaptive Landscape in Evolutionary Biology

The Adaptive Landscape in Evolutionary Biology

Author: Erik Svensson

Publisher: Oxford University Press

Published: 2012-05-17

Total Pages: 338

ISBN-13: 0199595372

DOWNLOAD EBOOK

The 'Adaptive Landscape' has been a central concept in population genetics and evolutionary biology since this powerful metaphor was first formulated in 1932. This volume brings together historians of science, philosophers, ecologists, and evolutionary biologists, to discuss the state of the art from several different perspectives.


Theoretical Aspects of Evolutionary Computing

Theoretical Aspects of Evolutionary Computing

Author: Leila Kallel

Publisher: Springer Science & Business Media

Published: 2013-03-09

Total Pages: 495

ISBN-13: 366204448X

DOWNLOAD EBOOK

During the first week of September 1999, the Second EvoNet Summer School on Theoretical Aspects of Evolutionary Computing was held at the Middelheim cam pus of the University of Antwerp, Belgium. Originally intended as a small get together of PhD students interested in the theory of evolutionary computing, the summer school grew to become a successful combination of a four-day workshop with over twenty researchers in the field and a two-day lecture series open to a wider audience. This book is based on the lectures and workshop contributions of this summer school. Its first part consists of tutorial papers which introduce the reader to a num ber of important directions in the theory of evolutionary computing. The tutorials are at graduate level andassume only a basic backgroundin mathematics and com puter science. No prior knowledge ofevolutionary computing or its theory is nec essary. The second part of the book consists of technical papers, selected from the workshop contributions. A number of them build on the material of the tutorials, exploring the theory to research level. Other technical papers may require a visit to the library.


The Origins of Order

The Origins of Order

Author: Stuart A. Kauffman

Publisher:

Published: 1993

Total Pages: 744

ISBN-13: 9780195079517

DOWNLOAD EBOOK

This monograph extends the basic concepts of Darwinian evolution to accommodate recent findings and perspectives from the fields of biology, physics, chemistry and mathematics. It explains how complex systems, contrary to expectations, can spontaneously exhibit degrees of order.


Cellular Automata and Cooperative Systems

Cellular Automata and Cooperative Systems

Author: N. Boccara

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 545

ISBN-13: 9401116911

DOWNLOAD EBOOK

This book contains the lectures given at the NATO Advanced Study Institute on `Cellular Automata and Cooperative Systems', held at Les Houches, France, from June 22 to July 2, 1992. The book contains contributions by mathematical and theoretical physicists and mathematicians working in the field of local interacting systems, cellular probabilistic automata, statistical physics, and complexity theory, as well as the applications of these fields.