Molecular Dynamics in Biosystems
Molecular Dynamics in Biosystems

Author: Kenneth H. Norwich

Publisher: Elsevier

Published: 2013-10-22

Total Pages: 418

ISBN-13: 1483151654

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Molecular Dynamics in Biosystems: The Kinetics of Tracers in Intact Organisms focuses on the measurement of the transport and turnover of molecules in an intact biological organism, emphasizing the kinetics of tracers, which is the primary tool used for such studies. Organized into seven chapters, the book begins by elucidating the relationship between tracer and tracee. The text then tackles the biokinetics of distributed systems; the theory of multicompartment systems; and the rates of appearance of tracee in both steady and nonsteady state systems. Lastly, this book explains the study of blood flow and the tracers utilized that are called indicators. This material forms part of a course on biokinetics offered by the University of Toronto. It will serve both as a text to students and as a reference for those engaged in research.

NanoBioMaterials
NanoBioMaterials

Author: Bhupinder Singh

Publisher: CRC Press

Published: 2018-06-14

Total Pages: 0

ISBN-13: 1351138642

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The present book volume presents a holistic view of the aspects of nanobiomaterials incl. their stellar merits and limitations, applications in diverse fields, their futuristic promise in the fields of biomedical science and drug delivery. The federal & regulatory issues on the usage of nanobiomaterials have been assigned due consideration.

Free Energy Calculations
Free Energy Calculations

Author: Christophe Chipot

Publisher: Springer Science & Business Media

Published: 2007-01-08

Total Pages: 528

ISBN-13: 3540384472

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Free energy constitutes the most important thermodynamic quantity to understand how chemical species recognize each other, associate or react. Examples of problems in which knowledge of the underlying free energy behaviour is required, include conformational equilibria and molecular association, partitioning between immiscible liquids, receptor-drug interaction, protein-protein and protein-DNA association, and protein stability. This volume sets out to present a coherent and comprehensive account of the concepts that underlie different approaches devised for the determination of free energies. The reader will gain the necessary insight into the theoretical and computational foundations of the subject and will be presented with relevant applications from molecular-level modelling and simulations of chemical and biological systems. Both formally accurate and approximate methods are covered using both classical and quantum mechanical descriptions. A central theme of the book is that the wide variety of free energy calculation techniques available today can be understood as different implementations of a few basic principles. The book is aimed at a broad readership of graduate students and researchers having a background in chemistry, physics, engineering and physical biology.

Molecular Dynamics
Molecular Dynamics

Author: Perla Balbuena

Publisher: Elsevier

Published: 1999-04-22

Total Pages: 971

ISBN-13: 0080536840

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The latest developments in quantum and classical molecular dynamics, related techniques, and their applications to several fields of science and engineering. Molecular simulations include a broad range of methodologies such as Monte Carlo, Brownian dynamics, lattice dynamics, and molecular dynamics (MD).Features of this book:• Presents advances in methodologies, introduces quantum methods and lists new techniques for classical MD• Deals with complex systems: biomolecules, aqueous solutions, ice and clathrates, liquid crystals, polymers• Provides chemical reactions, interfaces, catalysis, surface phenomena and solidsAlthough the book is not formally divided into methods and applications, the chapters are arranged starting with those that discuss new algorithms, methods and techniques, followed by several important applications.

RNA Polymerases as Molecular Motors
RNA Polymerases as Molecular Motors

Author: Robert Landick

Publisher: Royal Society of Chemistry

Published: 2021-11-23

Total Pages: 295

ISBN-13: 1839160667

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To thrive, every living cell must continuously gauge and respond to changes in its environment. These changes are ultimately implemented by modulating gene expression, a process that relies on transcription by Nature’s most multivalent molecular machine, the RNA polymerase. This book covers progress made over the past decade understanding how this machine functions to compute the cellular state, from the atomistic structural level responsible for chemistry to the integrative level at which RNA polymerase interacts with the other key molecular machineries of the cell.

Quantitative Understanding of Biosystems
Quantitative Understanding of Biosystems

Author: Thomas M. Nordlund

Publisher: CRC Press

Published: 2019-04-16

Total Pages: 870

ISBN-13: 1351801171

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Praise for the prior edition "The author has done a magnificent job... this book is highly recommended for introducing biophysics to the motivated and curious undergraduate student." ―Contemporary Physics "a terrific text ... will enable students to understand the significance of biological parameters through quantitative examples―a modern way of learning biophysics." ―American Journal of Physics "A superb pedagogical textbook... Full-color illustrations aid students in their understanding" ―Midwest Book Review This new edition provides a complete update to the most accessible yet thorough introduction to the physical and quantitative aspects of biological systems and processes involving macromolecules, subcellular structures, and whole cells. It includes two brand new chapters covering experimental techniques, especially atomic force microscopy, complementing the updated coverage of mathematical and computational tools. The authors have also incorporated additions to the multimedia component of video clips and animations, as well as interactive diagrams and graphs. Thomas Nordlund is professor emeritus in the Department of Physics at The University of Alabama at Birmingham. He is an elected fellow of the American Physical Society and has been studying biomolecular dynamics for over thirty years. Peter M. Hoffmann is a professor in the Department of Physics and Astronomy at Wayne State University in Detroit, Michigan, where he founded the biomedical physics program. He has been involved in soft matter and biophysics research for twenty-five years, and earned his PhD in materials science and engineering from Johns Hopkins University.

Fuzziness
Fuzziness

Author: Monika Fuxreiter

Publisher: Springer Science & Business Media

Published: 2012-03-07

Total Pages: 210

ISBN-13: 1461406595

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Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsically disordered proteins in complex eukaryotic signaling networks. In this volume, Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions. These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity. These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions.

Self-Organized Biological Dynamics and Nonlinear Control
Self-Organized Biological Dynamics and Nonlinear Control

Author: Jan Walleczek

Publisher: Cambridge University Press

Published: 2006-04-20

Total Pages: 444

ISBN-13: 1139427598

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The growing impact of nonlinear science on biology and medicine is fundamentally changing our view of living organisms and disease processes. This book introduces the application to biomedicine of a broad range of interdisciplinary concepts from nonlinear dynamics, such as self-organization, complexity, coherence, stochastic resonance, fractals and chaos. It comprises 18 chapters written by leading figures in the field and covers experimental and theoretical research, as well as the emerging technological possibilities such as nonlinear control techniques for treating pathological biodynamics, including heart arrhythmias and epilepsy. This book will attract the interest of professionals and students from a wide range of disciplines, including physicists, chemists, biologists, sensory physiologists and medical researchers such as cardiologists, neurologists and biomedical engineers.

Mucoadhesive Materials and Drug Delivery Systems
Mucoadhesive Materials and Drug Delivery Systems

Author: Vitaliy V. Khutoryanskiy

Publisher: John Wiley & Sons

Published: 2014-06-12

Total Pages: 424

ISBN-13: 1118794397

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Mucoadhesion defined as attachment of synthetic or natural materials to mucosal tissues has been widely exploited in pharmaceutical forms. This multi-author book provides an up-to-date account of current research on mucoadhesive materials and drug delivery systems. The introductory section describes the structure and physiology of various mucosal surfaces (oral, nasal, ocular, gastrointestinal and vaginal mucosa). This is followed by chapters on the various methods used to study mucoadhesion and to characterise mucoadhesive properties of various dosage forms. The final section will summarise information on traditional and novel types of mucoadhesive materials, such as chitosan, thiomers, and liposome-based formulations. This book is unique as there is currently no modern book considering mucoadhesion - all other existing books on the topic are either narrowly focused or more than 10 years old. Furthermore, each contributor offers specialist perspectives from a variety of global locations in both industrial and academic research centres.

Solving Software Challenges for Exascale
Solving Software Challenges for Exascale

Author: Stefano Markidis

Publisher: Springer

Published: 2015-02-18

Total Pages: 154

ISBN-13: 3319159763

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This volume contains the thoroughly refereed post-conference proceedings of the Second International Conference on Exascale Applications and Software, EASC 2014, held in Stockholm, Sweden, in April 2014. The 6 full papers presented together with 6 short papers were carefully reviewed and selected from 17 submissions. They are organized in two topical sections named: toward exascale scientific applications and development environment for exascale applications.