Models of Scientific Development and the Case of Nuclear Magnetic Resonance

Models of Scientific Development and the Case of Nuclear Magnetic Resonance

Author: Henk Zandvoort

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 318

ISBN-13: 940094764X

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From the nineteen sixties onwards a branch of philosophy of science has come to development, called history-oriented philosophy of science. This development constitutes a reaction on the then prevailing logical empiricist conception of scientific knowledge. The latter was increasingly seen as suffering from insurmountable internal problems, like e. g. the problems with the particular "observational-theoretical distinction" on which it drew. In addition the logical empiricists' general approach was increasingly criticized for two external shortcomings. Firstly, the examples of scientific knowledge that the logical empiricists were focusing on were con sidered as too simplistic to be informative on the nature of real life science. Secondly, it was felt that the attention of these philosophers of science was restricted to the static aspects of scientific knowledge, while neglecting its developmental aspects. History-oriented philosophy of science has taken up the challenge implicit in the latter two criticisms, i. e. to develop accounts of science that would be more adequate for understanding the development 1 of real life science. One of the more successful products of this branch of philosophy of science is Lakatos's theory of scientific development, sometimes called the "methodology of scientific research programmes". This theory conceives science as consisting of so called research program mes developing in time, and competing with each other over the issue which one generates the best explan~tions of the phenomena that they address.


Biological NMR Spectroscopy

Biological NMR Spectroscopy

Author: John L. Markley

Publisher: Oxford University Press

Published: 1997-01-30

Total Pages: 375

ISBN-13: 0195094689

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This book presents a critical assessment of progress on the use of nuclear magnetic resonance spectroscopy to determine the structure of proteins, including brief reviews of the history of the field along with coverage of current clinical and in vivo applications. The book, in honor of Oleg Jardetsky, one of the pioneers of the field, is edited by two of the most highly respected investigators using NMR, and features contributions by most of the leading workers in the field. It will be valued as a landmark publication that presents the state-of-the-art perspectives regarding one of today's most important technologies.


Compact NMR

Compact NMR

Author: Bernhard Blümich

Publisher: Walter de Gruyter GmbH & Co KG

Published: 2014-08-22

Total Pages: 305

ISBN-13: 3110374587

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The goal of this book is to provide an introduction to the practical use of mobile NMR at a level as basic as the operation of a smart phone. Each description follows the same didactic pattern: introduction, basic theory, pulse sequences and parameters, beginners-level measurements, advanced-level measurements, and data processing. Nuclear Magnetic Resonance (NMR) spectroscopy is the most popular method for chemists to analyze molecular structures while Magnetic Resonance Imaging (MRI) is a non-invasive diagnostic tool for medical doctors that provides high-contrast images of biological tissue depicting the brain function and the beating heart. In both applications large super-conducting magnets are employed which magnetize atomic nuclei of an object positioned inside the magnet. Their circulating motion is interrogated by radio-frequency waves. Depending on the operating mode, the frequency spectrum provides the chemist with molecular information, the medical doctor with anatomic images, while the materials scientist is interested in NMR relaxation parameters, which scale with material properties and determine the contrast in magnetic resonance images. Recent advances in magnet technology led to a variety of small permanent magnets, by which NMR spectra, images, and relaxation parameters can be measured with mobile and low-cost instruments.


High-resolution NMR Techniques in Organic Chemistry

High-resolution NMR Techniques in Organic Chemistry

Author: T. Claridge

Publisher: Elsevier

Published: 1999-12-24

Total Pages: 408

ISBN-13: 9780080427997

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From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.


Experimental Approaches of NMR Spectroscopy

Experimental Approaches of NMR Spectroscopy

Author: The Nuclear Magnetic Resonance Society of Japan

Publisher: Springer

Published: 2017-11-23

Total Pages: 634

ISBN-13: 9811059667

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This book describes the advanced developments in methodology and applications of NMR spectroscopy to life science and materials science. Experts who are leaders in the development of new methods and applications of life and material sciences have contributed an exciting range of topics that cover recent advances in structural determination of biological and material molecules, dynamic aspects of biological and material molecules, and development of novel NMR techniques, including resolution and sensitivity enhancement. First, this book particularly emphasizes the experimental details for new researchers to use NMR spectroscopy and pick up the potentials of NMR spectroscopy. Second, the book is designed for those who are involved in either developing the technique or expanding the NMR application fields by applying them to specific samples. Third, the Nuclear Magnetic Resonance Society of Japan has organized this book not only for NMR members of Japan but also for readers worldwide who are interested in using NMR spectroscopy extensively.


Nuclear Magnetic Resonance Spectroscopy of Liquid Crystals

Nuclear Magnetic Resonance Spectroscopy of Liquid Crystals

Author: Ronald Y. Dong

Publisher: World Scientific

Published: 2010

Total Pages: 462

ISBN-13: 981427366X

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This edited volume provides an extensive overview of how nuclear magnetic resonance can be an indispensable tool to investigate molecular ordering, phase structure, and dynamics in complex anisotropic phases formed by liquid crystalline materials. The chapters, written by prominent scientists in their field of expertise, provide a state-of-the-art scene of developments in liquid crystal research. The fantastic assortment of shape anisotropy in organic molecules leads to The discoveries of interesting new soft materials made at a rapid rate which not only inject impetus to address the fundamental physical and chemical phenomena, but also the potential applications in memory, sensor and display devices. The review volume also covers topics ranging from solute studies of molecules in nematics and biologically ordered fluids to theoretical approaches in treating elastic and viscous properties of liquid crystals. This volume is aimed at graduate students, novices and experts alike, and provides an excellent reference material for readers interested in the liquid crystal research. it is, indeed, a reference book for every science library to have.


Optical Magnetometry

Optical Magnetometry

Author: Dmitry Budker

Publisher: Cambridge University Press

Published: 2013-03-07

Total Pages: 431

ISBN-13: 1107010357

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Comprehensive coverage of the principles, technology and diverse applications of optical magnetometry for graduate students and researchers in atomic physics.


Applications of NMR Spectroscopy

Applications of NMR Spectroscopy

Author: Atta-ur-Rahman

Publisher: Bentham Science Publishers

Published: 2016-11-22

Total Pages: 289

ISBN-13: 168108287X

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Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The fifth volume of the series features several reviews focusing on NMR spectroscopic techniques for identifying natural and synthetic compounds (polymer and peptide characterization, GABA in tinnitus affected mice), medical diagnosis and therapy (gliomas) and food analysis. The spectroscopic methods highlighted in this volume include high resolution proton magnetic resonance spectroscopy and solid state NMR.


Calculation of NMR and EPR Parameters

Calculation of NMR and EPR Parameters

Author: Martin Kaupp

Publisher: John Wiley & Sons

Published: 2006-03-06

Total Pages: 621

ISBN-13: 3527604960

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This is the first book to present the necessary quantum chemical methods for both resonance types in one handy volume, emphasizing the crucial interrelation between NMR and EPR parameters from a computational and theoretical point of view. Here, readers are given a broad overview of all the pertinent topics, such as basic theory, methodic considerations, benchmark results and applications for both spectroscopy methods in such fields as biochemistry, bioinorganic chemistry as well as with different substance classes, including fullerenes, zeolites and transition metal compounds. The chapters have been written by leading experts in a given area, but with a wider audience in mind. The result is the standard reference on the topic, serving as a guide to the best computational methods for any given problem, and is thus an indispensable tool for scientists using quantum chemical calculations of NMR and EPR parameters. A must-have for all chemists, physicists, biologists and materials scientists who wish to augment their research by quantum chemical calculations of magnetic resonance data, but who are not necessarily specialists in these methods or their applications. Furthermore, specialists in one of the subdomains of this wide field will be grateful to find here an overview of what lies beyond their own area of focus.