Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves
Modeling Human Atrial Patho-Electrophysiology from Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Author: Loewe, Axel

Publisher: KIT Scientific Publishing

Published: 2016-08-03

Total Pages: 342

ISBN-13: 3731505282

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Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF.

Cardiac Modeling: Aiming for Optimization of Therapy
Cardiac Modeling: Aiming for Optimization of Therapy

Author: Javier Saiz

Publisher: Frontiers Media SA

Published: 2020-12-15

Total Pages: 248

ISBN-13: 2889662195

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This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms
Multiscale Cohort Modeling of Atrial Electrophysiology : Risk Stratification for Atrial Fibrillation through Machine Learning on Electrocardiograms

Author: Nagel, Claudia

Publisher: KIT Scientific Publishing

Published: 2023-04-24

Total Pages: 280

ISBN-13: 3731512815

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An early detection and diagnosis of atrial fibrillation sets the course for timely intervention to prevent potentially occurring comorbidities. Electrocardiogram data resulting from electrophysiological cohort modeling and simulation can be a valuable data resource for improving automated atrial fibrillation risk stratification with machine learning techniques and thus, reduces the risk of stroke in affected patients.

Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach
Characterizing Cardiac Electrophysiology during Radiofrequency Ablation : An Integrative Ex vivo, In silico, and In vivo Approach

Author: Pollnow, Stefan

Publisher: KIT Scientific Publishing

Published: 2019-04-23

Total Pages: 296

ISBN-13: 3731508869

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Catheter ablation is a major treatment for atrial tachycardias. Hereby, the precise monitoring of the lesion formation is an important success factor. This book presents computational, wet-lab, and clinical studies with the aim of evaluating the signal characteristics of the intracardiac electrograms (IEGMs) recorded around ablation lesions from different perspectives. The detailed analysis of the IEGMs can optimize the description of durable and complex lesions during the ablation procedure.

A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy
A Multiscale In Silico Study to Characterize the Atrial Electrical Activity of Patients With Atrial Fibrillation : A Translational Study to Guide Ablation Therapy

Author: Sánchez Arciniegas, Jorge Patricio

Publisher: KIT Scientific Publishing

Published: 2022-05-30

Total Pages: 162

ISBN-13: 3731511703

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The atrial substrate undergoes electrical and structural remodeling during atrial fibrillation. Detailed multiscale models were used to study the effect of structural remodeling induced at the cellular and tissue levels. Simulated electrograms were used to train a machine-learning algorithm to characterize the substrate. Also, wave propagation direction was tracked from unannotated electrograms. In conclusion, in silico experiments provide insight into electrograms' information of the substrate.

Modeling Human Atrial Patho-Electrophysiology From Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves
Modeling Human Atrial Patho-Electrophysiology From Ion Channels to ECG - Substrates, Pharmacology, Vulnerability, and P-Waves

Author: Axel Loewe

Publisher:

Published: 2020-10-09

Total Pages: 334

ISBN-13: 9781013283864

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Half of the patients suffering from atrial fibrillation (AF) cannot be treated adequately, today. This book presents multi-scale computational methods to advance our understanding of patho-mechanisms, to improve the diagnosis of patients harboring an arrhythmogenic substrate, and to tailor therapy. The modeling pipeline ranges from ion channels on the subcellular level up to the ECG on the body surface. The tailored therapeutic approaches carry the potential to reduce the burden of AF. This work was published by Saint Philip Street Press pursuant to a Creative Commons license permitting commercial use. All rights not granted by the work's license are retained by the author or authors.

Atrial Fibrillation
Atrial Fibrillation

Author: Rodney H. Falk

Publisher: Lippincott Williams & Wilkins

Published: 1997

Total Pages: 554

ISBN-13:

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This revised edition offers guidance on evaluation and management of atrial fibrillation and describes pharmacological, electrophysical, and surgical therapies. Coverage includes revised chapters on echocardiography, anti-coagulant therapy, and catheter ablation, and new chapters on atrial flutter, basic electrophysiology of antiarrhythmic drugs, implantable atrial defibrillators, and conduction through the atrioventricular node. Also included are chapters on decision analysis in the treatment of atrial fibrillation and on the special problems of paroxysmal atrial fibrillation.

Modeling and Simulating Cardiac Electrical Activity
Modeling and Simulating Cardiac Electrical Activity

Author: David J. Christini

Publisher:

Published: 2020

Total Pages: 0

ISBN-13: 9780750320641

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This book provides a thorough introduction to the topic of mathematical modeling of electrical activity in the heart, from molecular details of ionic channel dynamics to clinically derived patient-specific models. It discusses how cellular ionic models are formulated, introduces commonly used models and explains why there are so many different models available. The chapters cover modeling of the intracellular calcium handling that underlies cellular contraction as well as modeling molecular-level details of cardiac ion channels, and also focus on specialized topics such as cardiomyocyte energetics and signalling pathways. It is an excellent resource for experienced and specialised researchers in the field, but also biological scientists with a limited background in mathematical modelling and computational methods. Part of Biophysical Society-IOP series.

Cardiology Explained
Cardiology Explained

Author: Euan A. Ashley

Publisher: Remedica

Published: 2004

Total Pages: 258

ISBN-13: 1901346226

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One of the most time-consuming tasks in clinical medicine is seeking the opinions of specialist colleagues. There is a pressure not only to make referrals appropriate but also to summarize the case in the language of the specialist. This book explains basic physiologic and pathophysiologic mechanisms of cardiovascular disease in a straightforward manner, gives guidelines as to when referral is appropriate, and, uniquely, explains what the specialist is likely to do. It is ideal for any hospital doctor, generalist, or even senior medical student who may need a cardiology opinion, or for that ma.