Mineralizing Vesicles
Mineralizing Vesicles

Author: Massimo Bottini

Publisher: Elsevier

Published: 2023-11-17

Total Pages: 450

ISBN-13: 0323991599

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Mineralizing Vesicles: From Biochemical and Biophysical Properties to Their Roles in Physiology and Disease presents the state-of-the art in the properties of mineralizing EVs and their potential clinical applications. The first chapter presents foundational biochemical and biological aspects of EVs. Next, the title coves the role of EVs in bone ossification and in cardiovascular and cartilage-related diseases. Considering the unique ability of this class of EVs to form apatite minerals assigned to their special biochemical machinery, three chapters of the book then focus on the enzymes catalysing the inorganic phosphate and calcium turn-over and the dynamic properties of the vesicles' peripheral proteins. Chapters describe the role of inorganic phosphate and calcium ions and of autophagy on the biogenesis and function of mineralizing EVs. Recent studies show that the lumen of mineralizing EVs is partially filled with miRNA, and a chapter therefore considers research on the possible function of these vesicles as signalosomes. The final five chapters of the book describe practical aspects of working with mineralizing EVs, including their purification, proteomic and biophysical analyses, the use of biomimetic models and mineralizing EVs in regenerative medicine. This title presents, for the first time, a comprehensive account of mineralizing EVs and their potential clinical applications. It will be invaluable to researchers in the field. • Covers all aspects of mineralizing EVs, from their composition to their function in physiological and pathological processes, and their clinical potential• Presents mineralizing EVs systematically using clear accessible language• Describes practical aspects of working with mineralizing EVs• Integrates an account of the biochemistry and biophysics of vesicles with their functions• Takes a multidisciplinary perspective, offering an exhaustive and cutting-edge account of mineralizing EVs and human health

The Growth Plate
The Growth Plate

Author: Irving M. Shapiro

Publisher: IOS Press

Published: 2002

Total Pages: 312

ISBN-13: 9781586032401

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Evidence generated by a number of genetic studies indicates that growth is regulated by a number of genes and that interference with their expression can have catastrophic effects on the well being of the whole organism. This work covers skeletal development and growth.

Annexins
Annexins

Author: Joanna Bandorowicz-Pikula

Publisher: Springer Science & Business Media

Published: 2003-07-31

Total Pages: 298

ISBN-13: 9780306478345

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The Annexins is focused on a specific family of calcium and membrane-binding proteins, annexins, ubiquitously spread within living organisms, including animals, plants and fungi. The volume covers important areas of annexinology. The characterization of structural-functional relationship within the annexin family of proteins, together with emerging transgenic animal models, provides an up-to-date overview of potential physiological roles of annexins. Growing evidence of participation of annexins in human diseases, called annexinopathies, related to disturbances in signal transduction, vesicular traffic, ion homeostasis and energy metabolism within the cell. The book will attract a broad scientific audience, not only scientists interested in annexins, but also others involved in multidisciplinary studies, as well as undergraduate and postgraduate students. It can be used in courses relating to special topics such as calcium homeostasis, calcium-binding proteins, membrane structure and transport properties, various signal transduction pathways, and membrane trafficking.

Origin, Evolution, and Modern Aspects of Biomineralization in Plants and Animals
Origin, Evolution, and Modern Aspects of Biomineralization in Plants and Animals

Author: Rex E. Crick

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 532

ISBN-13: 1475761147

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The Fifth International Biomineralization Symposium was held in May 1986 at The University of Texas at Arlington, Arlington, Texas. The chosen theme was the origin, evolution and modern aspects of biomineralization in plants and animals. Thus, the symposium was designed to bring together experts in ocean and atmospheric chemistry, geochemistry, paleontology, biology, medicine and related fields to share accumulated knowledge and to broaden research horizons. The contents of this volume reflect the diversified interests and views of contributors from these fields. Topics range from contrasting views of the origin of ocean chemistry, the cause or causes for the biomineralization among plants and animals, the evolution of style and structure of biomineralization, and the role of inorganic and organic compounds in biomineraliza tion. It was clear from those gathered in Arlington that the efforts of all researchers in any aspect of biomineralization can be strengthened and extended by greater exposure to the work of others in allied fields. At the time of this printing, several collaborative efforts have grown from interest and contacts developed during the symposium. Rex E. Crick viii ACKNOWLEDGEMENTS The symposium would not have occurred with the financial support of The Organized Research Fund of The University of Texas at Arlington and The Sea Grant Program administered by Texas A & M University. The staff of the Department of Geology of The University of Texas at Arlington were largely responsible for providing a pleasant atmosphere for learning.

Dynamics of Bone and Cartilage Metabolism
Dynamics of Bone and Cartilage Metabolism

Author: Markus J. Seibel

Publisher: Elsevier

Published: 2006-07-24

Total Pages: 945

ISBN-13: 008045626X

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This updated edition is a comprehensive treatise that spans the complete range of basic biochemistry of bone and cartilage components to the clinical evaluation of disease markers in bone and joint disorders. With contributions from over 75 international experts, Dynamics of Bone and Cartilage Metabolism, Second Edition, is indispensable reading for those involved in skeletal research as well as for rheumatologists, endocrinologists, clinical biochemists, and other clinical disciplines participating in the management of patients with bone and cartilage diseases. - Part I provides an up-to-date account of current knowledge of the structure, biosynthesis and molecular biology of the major tissue components - Part II covers the organizational structure and cellular metabolism of bone and cartilage - Part III deals with the utility of components specific to bone and cartilage as biomarkers of health and disease

Ten Cate's Oral Histology
Ten Cate's Oral Histology

Author: Antonio Nanci

Publisher: Elsevier Health Sciences

Published: 2008-01-01

Total Pages: 432

ISBN-13: 032304557X

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Accompanying CD-ROM contains ... "150 color images with legends, 472 book figures with legends, 438 multiple choice test questions, and 119 interactive drag-and-drop exercises." -- from CD-ROM Welcome screen.

International Cell Biology 1980–1981
International Cell Biology 1980–1981

Author: Hans G. Schweiger

Publisher: Springer

Published: 2013-12-14

Total Pages: 1045

ISBN-13: 3662399326

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In September, 1976, the International Federation for Cell Biology held its first congress in Boston. On this occasion Berlin was chosen as the site for the next congress. This meant an acknowledgement and at the same time a heavy burden for the still young European Cell Biology Organization, which repre sents a junction of European societies and groups for cell biology. In practical terms, this meant that the members of the young and, compared to the Ame rican Society for Cell Biology, small German Society for Cell Biology had to do a good deal of the organizing of the Cell Biology Congress. This is an op portunity for me, as Chairman of the Organizing Committee, and also on be half of the German Society for Cell Biology, to express my gratitude to all those who have actively participated in the preparations for this Cell Biology Congress. The success of the Congress in Berlin was to a significant extent due to their work. In particular, I would like to especially thank the Secretary General ofECBO Werner Franke, Heidelberg, as well as the Chairman of the Local Organizing Committee, Peter Giesbrecht, Berlin, for the excellent job they did. The Congress in Berlin proved to be significantly larger than that in Boston in 1976. The number of abstracts increased from 1200 to more than 1800. They have been published in the European Journal of Cell Biology. In a simi lar way the number of symposia and workshops expanded.

Cardiovascular Calcification and Bone Mineralization
Cardiovascular Calcification and Bone Mineralization

Author: Elena Aikawa

Publisher: Springer Nature

Published: 2020-07-01

Total Pages: 564

ISBN-13: 3030467252

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The book covers the basic science and clinical aspects of cardiovascular calcification and bone mineralization. Cardiovascular calcification is the leading predictor of cardiovascular morbidity and mortality, with a predictive value more significant than blood lipid levels. The presence of calcific mineral in cardiovascular tissues alters biomechanical performance, increasing workload on the heart and potentiating atherosclerotic plaque rupture and subsequent heart attack and stroke. This book examines the role of calcification in cardiovascular disease covering topics such as calcification in the atherosclerotic plaques and aortic valves arteries and valves, aortic valve replacement, peripheral artery disease, imaging of early calcification and target discovery. In addition, various forms of ectopic calcification as well as mechanisms of bone mineralization are discussed. Cardiovascular Calcification and Bone Mineralization is an essential resource for clinicians, researchers, and other medical professionals in cardiology, pathology, and biomedical engineering.

The Comparative Molecular Biology of Extracellular Matrices
The Comparative Molecular Biology of Extracellular Matrices

Author: Harold Slavkin

Publisher: Academic Press

Published: 2012-12-02

Total Pages: 493

ISBN-13: 0323148220

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The Comparative Molecular Biology of Extracellular Matrices reviews and assesses the comparative molecular biology of extracellular matrices. It covers six areas that are advanced to supplement this study. These include the molecular biology of collagen, monopolysaccharides, proteoglycans, and structural glycoproteins; development process of extracellular matrices; cell surfaces and interactions; evolution of bone and some tissues; and biophysical properties of connective tissues.

Biological Mineralization and Demineralization
Biological Mineralization and Demineralization

Author: G.H. Nancollas

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 411

ISBN-13: 3642685749

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normal and pathological mineralization in vertebrates but also with the interesting problems involved in the formation of in tracellular deposits of calcium oxalate in plants. Here cal cium carbonate and silica may also be involved in the mineral ization processes. Calcium carbonate is an important component in the formation of mollusc and avian shells. The observation that both calcite and aragonite may be formed in biogenic cal cium carbonate raises important questions as to what factors control the formation of the final mineral phase. There is little doubt that thermodynamically less stable phases may be kinetically stabilized for long periods of time by other mole cules present in vivo. In normal mineralization, calcium salts may initially be deposited both within the cells and extracel lularly. In the latter case, the role of matrix vesicles and the ways in which the matrix components might control mineral ization were especially emphasized. There is clearly a need for more structural and functional information involving cells, matrix components, and their associated crystals. The develop ment of further techniques involving mutants, chromofluors, and fixatives for preservation of tissue and the ions present in vivo was recommended. In dealing with abnormal and pathological mineralization, the Workshop concentrated on urolithiasis, gout and pseudo-gout, and the formation of dental caries. Discussions based on the influence of media of low pH on mineral surfaces highlighted some of the factors of importance in controlling crystal dis solution.