Mild Cognitive Impairment
Mild Cognitive Impairment

Author: Ronald C. Petersen

Publisher: Oxford University Press

Published: 2003-01-09

Total Pages: 286

ISBN-13: 0198028741

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What are the boundary zones between normal aging and Alzheimer's disease (AD)? Are many elderly people whom we regard as normal actually in the early stages of AD? Alzheimer's disease does not develop overnight; the early phases may last for years or even decades. Recently, clinical investigators have identified a transitional condition between normal aging and and very early Alzheimer's disease that they have called mild cognitive impairment, or MCI. This term typically refers to memory impairment beyond what one would expect in individuals of a given age whose other abilities to function in daily life are well preserved. Persons who meet the criteria for mild cognitive impairment have an increased risk of progressing to Alzheimer's disease in the near future. Though many questions about this condition and its underlying neuropathology remain open, full clinical trials are currently underway worldwide aimed at preventing the progression from MCI to Alzheimer's disease. This book addresses the spectrum of issues involved in mild cognitive impairment, and includes chapters on clinical studies, neuropsychology, neuroimaging, neuropathology, biological markers, diagnostic approaches, and treatment. It is intended for clinicians, researchers, and students interested in aging and cognition, among them neurologists, psychiatrists, geriatricians, clinical psychologists, and neuropsychologists.

Alzheimer’s Disease - From Basic Research to Clinical Applications
Alzheimer’s Disease - From Basic Research to Clinical Applications

Author: Hermann J. Gertz

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 313

ISBN-13: 3709175089

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As human longevity continues to be extended, so will the impact of age-associated dementia on individual lives and society. Alzheimer’s disease as the most common cause of dementia in the elderly remains a sentinal problem and its underlying pathology is still poorly understood. Available therapeutic strategies require considerable refinement and the development of new therapeutic strategies need input from basic research. Thus continued efforts are necessary both to understand basic mechanisms of the condition and to achieve more powerfull therapies. This volume brings together the reports of basic scientists and clinical investigators. The chapters provide a spectrum of information valuable for clinicians and scientists. This issue bridges the gap between laboratory work in basic science and the development of urgently needed therapeutic strategies. Areas presented are the molecular and cellular biology of the disease, pathogenetic mechanisms and potential therapeutic targets, genetics, risk factors, strategies of prevention and treatment as well as practical aspects of medical and social care for patients with Alzheimer’s disease.

Mild Cognitive Impairment and Early Alzheimer's Disease
Mild Cognitive Impairment and Early Alzheimer's Disease

Author: Jeffrey M. Burns

Publisher: John Wiley & Sons

Published: 2008-05-27

Total Pages: 168

ISBN-13:

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Written by leading authorities in the field, this book describes the cognitive changes associated with age, the earliest detectable stages of Alzheimer’s, and the relationship of these conditions to MCI. The authors review the latest advances in our understanding of MCI, its prevalence, evaluation, management, and outcomes and in so doing provide practising physicians with a useful resource that assists them in identifying those MCI patients who will progress to recognised Alzheimer’s Disease. Beautifully presented in full colour, Early Diagnosis and Treatment of Mild Cognitive Impairment includes case studies and discusses future therapeutic and diagnostic strategies. It is an invaluable resource for postgraduates and professionals, for specialist physicians in neurology and psychiatric medicine, geriatric medicine and general practice.

Preventing Cognitive Decline and Dementia
Preventing Cognitive Decline and Dementia

Author: National Academies of Sciences, Engineering, and Medicine

Publisher: National Academies Press

Published: 2017-10-05

Total Pages: 181

ISBN-13: 0309459591

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Societies around the world are concerned about dementia and the other forms of cognitive impairment that affect many older adults. We now know that brain changes typically begin years before people show symptoms, which suggests a window of opportunity to prevent or delay the onset of these conditions. Emerging evidence that the prevalence of dementia is declining in high-income countries offers hope that public health interventions will be effective in preventing or delaying cognitive impairments. Until recently, the research and clinical communities have focused primarily on understanding and treating these conditions after they have developed. Thus, the evidence base on how to prevent or delay these conditions has been limited at best, despite the many claims of success made in popular media and advertising. Today, however, a growing body of prevention research is emerging. Preventing Cognitive Decline and Dementia: A Way Forward assesses the current state of knowledge on interventions to prevent cognitive decline and dementia, and informs future research in this area. This report provides recommendations of appropriate content for inclusion in public health messages from the National Institute on Aging.

Neurology in Clinical Practice
Neurology in Clinical Practice

Author: Walter George Bradley

Publisher:

Published: 2004

Total Pages: 1672

ISBN-13: 9780750674690

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New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Living with Mild Cognitive Impairment
Living with Mild Cognitive Impairment

Author: Nicole D. Anderson

Publisher: Oxford University Press

Published: 2012-08-23

Total Pages: 384

ISBN-13: 0199764824

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This book is for individuals with mild cognitive impairment (MCI), their loved ones, and health care professionals who care for these patients. The text is loaded with up-to-date, scientifically substantiated knowledge about what MCI is, how it affects people, and how to take a proactive approach to health and wellbeing for living with MCI.

Biomarkers in Alzheimer's Disease
Biomarkers in Alzheimer's Disease

Author: Tapan Khan

Publisher: Academic Press

Published: 2016-08-02

Total Pages: 278

ISBN-13: 0128051477

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Biomarkers in Alzheimer's Disease provides a comprehensive overview of all modalities of Alzheimer's disease biomarkers, including neuroimaging, cerebrospinal fluid, genomic, and peripheral systems. Each chapter integrates molecular/cellular abnormality due to Alzheimer's disease and technological advancement of biomarkers techniques. The book is ideal for clinical neuroscience and molecular/cellular neuroscience researchers, psychiatrists, and allied healthcare practitioners involved in the diagnosis and management of patients with cognitive impairment and Alzheimer's disease, and for differential diagnosis of Alzheimer's disease with other non-Alzheimer's dementia. - Presents a comprehensive overview detailing all modalities of Alzheimer's disease biomarkers - Written for neuroscience researchers and clinicians studying or treating patients with Alzheimer's Disease - Integrates, in each chapter, the molecular/cellular abnormality due to Alzheimer's disease and the technological advancement of biomarkers techniques

Alzheimer's Disease
Alzheimer's Disease

Author: Khalid Iqbal

Publisher: John Wiley & Sons

Published: 2001

Total Pages: 900

ISBN-13:

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Alzheimer's Disease is an ever-present problem affecting millions of people around the world and, as people's average lifespan lengthens, its prevalence is set to increase. A global effort is needed to combat the disease, including research to investigate the causes, development of effective treatments and, ultimately, prevention of the disease. Published every two years, these timely books discuss the very latest research. This new volume in the series: Provides a uniques source of reference to the important work being done in this field Gives academics and clinicians an opportunity to learn about cutting edge developments Covers all aspects of Alzheimer's Disease, including diagnosis, clinical course, epidemiological course and therapeutics and disease mechanisms. Alzheimer's Disease: Advances in Etiology, Pathogenesis and Therapeutics and Therapeutics will provide essential information for basic and clinical researchers in Alzheimer's Disease and other dementias as well as for those who care for patients.

White Matter Dementia
White Matter Dementia

Author: Christopher M. Filley

Publisher: Cambridge University Press

Published: 2016-04-28

Total Pages: 231

ISBN-13: 1107035414

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Presenting the novel concept of white matter dementia, this unique book offers hope for a better understanding and treatment of dementia.

Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders
Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders

Author: Adeboye Adejare

Publisher: Academic Press

Published: 2016-09-20

Total Pages: 310

ISBN-13: 0128028114

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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer's Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer's Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer's Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer's Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. - Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders - Examines different classes of compounds currently being used in discovery and development stages - Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions - Distills the most significant information across multiple areas of Alzheimer's disease research to provide a single, comprehensive, and balanced resource