Microperimetry allows precise functional examination of the retina and optic nerve and is especially valuable for evaluation of the macular area. This fully up-to-date textbook on microperimetry, written by leading experts in the field, will also serve as an atlas and diagnostic reference. It is designed for use by both ophthalmologists and optometrists in daily clinical practice and clinical research, and the contents thus range from basic technical information to the most advanced clinical applications. Past and current microperimetry techniques are reviewed, and the role of microperimetry in the context of multimodal imaging scenario is explained. The full range of clinical applications is then discussed, including age-related macular degeneration, diabetes, myopia, retinal dystrophies, disorders of the vitreoretinal interface, inflammatory chorioretinal diseases, toxic retinopathies, glaucoma, and low vision.
This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
span style="font-size: xx-small;"Retinal imaging techniques are used to diagnose and screen for various conditions such as macular degeneration and glaucoma. Equally importantly, they are used to monitor the progression of previously diagnosed conditions.
This book contains the proceedings of the XVIII International Symposium on Retinal Degeneration (RD2018). A majority of those who spoke and presented posters at the meeting contributed to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium focused on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume presents representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations were described, there will be many new topics that either are in their infancy or did not exist at the time of the last RD Symposium, RD2016. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those were reported at the RD2016 meeting and included in the current volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations is reflected in the volume.
This book explains the underlying rationale for retinal and choroidal imaging in the context of systemic diseases. Various systemic diseases involve the eyes, and for some, the eyes could provide the first clue to their presence. Advances in posterior segment imaging have significantly improved our understanding of the pathophysiology and management of posterior segment diseases. However, imaging techniques like enhanced depth imaging, oximetry, adaptive optics, and retinal blood flowmetry have remained largely unexplored in connection with systemic diseases. Enhancing the available literature on the use of such imaging techniques for various systemic diseases, this handbook will help readers understand their pathomechanisms, supporting early diagnosis and more targeted therapeutic approaches. As such, it offers an essential resource for ophthalmologists, especially those with predominantly vitreo-retinal and uvea experience.
This book will contain the proceedings of the XIV International Symposium on Retinal Degeneration (RD2010), held July 13-17, 2010, in Mont-Tremblant, Quebec, Canada. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy.
This book presents the latest knowledge and expert guidance on all aspects of inherited retinal diseases, including molecular genetics, diagnosis, clinical features, general principles of treatment, novel treatment methods, and genetic counseling. Recent years have witnessed great advances in understanding of the genetic and cytological background of these diseases. Genetic analysis methods such as next generation sequencing have remarkably reduced the cost and time required for massive analysis of patients’ samples. Studies on gene therapy and stem cell therapy have been successfully carried out in animal models, and gene therapy is now available for Leber congenital amaurosis caused by RPE65 mutations. Against this background, Inherited Retinal Disease will be an invaluable up-to-date resource for ophthalmologists, medical students, and researchers in ocular inflammation. In addition to supplying essential information on each individual disorder, it features many interesting cases contributed by global leaders in the field as well as clinical photographs obtained with newer imaging techniques and numerous images of rare but clinically important diseases.
This book covers the entire range of vitreoretinal surgeries. The first section covers essential information about the anatomy and the appropriate diagnostic techniques which helps in preoperative evaluation. The second section is on surgical instrumentation, and includes adjuncts used in VR surgery. Advanced instrumentation such as 3D visualization system, endoscopic vitrectomy and robotic surgeries are well described in the chapters. The later sections deal with the surgical technique for different disease entities. Management of posterior segment complication of anterior segment surgeries such as cataract and keratoprosthesis are reviewed in detail. A section on gene therapy has been incorporated. This book will help the reader to gather a detailed round-up of basics of and advances made in the field of vitreoretinal surgery. It is supplemented with videos. This book is meant for practicing retinal surgeons, those in training as well as students with interest in vitreoretinal surgery.
This book is a comprehensive guide to the imaging techniques that have revolutionized the diagnosis and management of uveitis during the past decade, including optical coherence tomography (OCT), enhanced depth imaging, fundus autofluorescence, and wide-field angiography. In addition, the current role of the traditional (invasive) gold standard techniques, fluorescein angiography and indocyanine green angiography, is described. Among the newer imaging modalities, detailed attention is paid to the various OCT technologies such as spectral domain OCT, enhanced-depth imaging OCT, and enface swept-source OCT. Further individual chapters focus on imaging using adaptive optics, multiview OCT, and OCT angiography. Uveitis can affect virtually any structure in the eye, and imaging of these structures is critical in the diagnosis, prognosis, and management of the disease. Increasing use and better understanding of the different modalities described in this book are sure to improve our knowledge of disease mechanisms and likely outcomes.
This book will focus for the first time on how to avoid complications of uveitis, or how to deal with them either surgically or medically. Its uniqueness lies in the fact that all other books available on the subject of uveitis concentrate on pathogenesis, natural course, diagnosis and treatment of the uveitic entity itself, barely touching complications arising from inflammation. This book will be divided in chapters, each of them concentrating on a particular portion of the eye, from front to back, and how it can get affected by complications from inflammation. Inflammatory diseases causing these complications will be just superficially touched, the main focus will be the pathogenesis of the actual complication, prevention and treatment. Every chapter will be introduced by a section by a uveitis specialist on how inflammation can cause that particular complication, and how we can avoid it. Then a specialist in the sector (cornea surgeon, glaucoma surgeon, etc) will describe management of the complication. This multi-disciplinary approach to complications of uveitis will provide to the readers the tools to prevent them, or to correctly manage the. It will be a book mainly directed to uveitis specialist but that could also interest other specialists.
