Open Microfluidics

Open Microfluidics

Author: Jean Berthier

Publisher: John Wiley & Sons

Published: 2016-07-20

Total Pages: 384

ISBN-13: 1118720822

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Open microfluidics or open-surface is becoming fundamental in scientific domains such as biotechnology, biology and space. First, such systems and devices based on open microfluidics make use of capillary forces to move fluids, without any need for external energy. Second, the "openness" of the flow facilitates the accessibility to the liquid in biotechnology and biology, and reduces the weight in space applications. This book has been conceived to give the reader the fundamental basis of open microfluidics. It covers successively The theory of spontaneous capillary flow, with the general conditions for spontaneous capillary flow, and the dynamic aspects of such flows. The formation of capillary filaments which are associated to small contact angles and sharp grooves. The study of capillary flow in open rectangular, pseudo-rectangular and trapezoidal open microchannels. The dynamics of open capillary flows in grooves with a focus on capillary resistors. The case of very viscous liquids is analyzed. An analysis of suspended capillary flows: such flows move in suspended channels devoid of top cover and bottom plate. Their accessibility is reinforced, and such systems are becoming fundamental in biology. An analysis of “rails” microfluidics, which are flows that move in channels devoid of side walls. This geometry has the advantage to be compatible with capillary networks, which are now of great interest in biotechnology, for molecular detection for example. Paper-based microfluidics where liquids wick flat paper matrix. Applications concern bioassays such as point of care devices (POC). Thread-based microfluidics is a new domain of investigation. It is seeing presently many new developments in the domain of separation and filtration, and opens the way to smart bandages and tissue engineering. The book is intended to cover the theoretical aspects of open microfluidics, experimental approaches, and examples of application.


Biomedical Microsystems

Biomedical Microsystems

Author: Ellis Meng

Publisher: CRC Press

Published: 2011-06-22

Total Pages: 410

ISBN-13: 1420051237

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Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications. Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. A solutions manual is available for instructors who want to convert this reference to classroom use.


Microfluidics for Biologists

Microfluidics for Biologists

Author: Chandra K. Dixit

Publisher: Springer

Published: 2016-10-13

Total Pages: 256

ISBN-13: 3319400363

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This book describes novel microtechnologies and integration strategies for developing a new class of assay systems to retrieve desired health information from patients in real-time. The selection and integration of sensor components and operational parameters for developing point-of-care (POC) are also described in detail. The basics that govern the microfluidic regimen and the techniques and methods currently employed for fabricating microfluidic systems and integrating biosensors are thoroughly covered. This book also describes the application of microfluidics in the field of cell and molecular biology, single cell biology, disease diagnostics, as well as the commercially available systems that have been either introduced or have the potential of being used in research and development. This is an ideal book for aiding biologists in understanding the fundamentals and applications of microfluidics. This book also: Describes the preparatory methods for developing 3-dimensional microfluidic structures and their use for Lab-on-a-Chip design Explains the significance of miniaturization and integration of sensing components to develop wearable sensors for point-of-care (POC) Demonstrates the application of microfluidics to life sciences and analytical chemistry, including disease diagnostics and separations Motivates new ideas related to novel platforms, valving technology, miniaturized transduction methods, and device integration to develop next generation sequencing Discusses future prospects and challenges of the field of microfluidics in the areas of life sciences in general and diagnostics in particular


Microfluidics

Microfluidics

Author: Bastian E. Rapp

Publisher: Elsevier

Published: 2022-10-07

Total Pages: 850

ISBN-13: 0128240237

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Microfluidics: Modeling, Mechanics and Mathematics, Second Edition provides a practical, lab-based approach to nano- and microfluidics, including a wealth of practical techniques, protocols and experiments ready to be put into practice in both research and industrial settings. This practical approach is ideally suited to researchers and R&D staff in industry. Additionally, the interdisciplinary approach to the science of nano- and microfluidics enables readers from a range of different academic disciplines to broaden their understanding. Alongside traditional fluid/transport topics, the book contains a wealth of coverage of materials and manufacturing techniques, chemical modification/surface functionalization, biochemical analysis, and the biosensors involved. This fully updated new edition also includes new sections on viscous flows and centrifugal microfluidics, expanding the types of platforms covered to include centrifugal, capillary and electro kinetic platforms. - Provides a practical guide to the successful design and implementation of nano- and microfluidic processes (e.g., biosensing) and equipment (e.g., biosensors, such as diabetes blood glucose sensors) - Provides techniques, experiments and protocols that are ready to be put to use in the lab, or in an academic or industry setting - Presents a collection of 3D-CAD and image files on a companion website


BioMEMS and Biomedical Nanotechnology

BioMEMS and Biomedical Nanotechnology

Author: Rashid Bashir

Publisher: Springer Science & Business Media

Published: 2007-04-03

Total Pages: 420

ISBN-13: 0387258450

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Annotation Volume 4 is a balanced review of key aspects of BioMEMS sensors, including (i) BioMEMS sensors and materials, (ii) means of manipulating biological entities at the microscale, and (iii) micro-fluidics and characterization. These three sections provide a succinct review of important topics within one volume of this series.


Single Biomolecule Detection and Analysis

Single Biomolecule Detection and Analysis

Author: Tuhin Subhra Santra

Publisher: CRC Press

Published: 2023-08-15

Total Pages: 355

ISBN-13: 1000916650

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This collection discusses various micro/nanodevice design and fabrication for single-biomolecules detection. It will be an ideal reference text for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. This book- Discusses techniques of single-biomolecule detection, their advantages, limitations, and applications. Covers comprehensively several electrochemical detection techniques. Provides single-molecule separation, sensing, imaging, sequencing, and analysis in detail. Examines different types of cantilever-based biomolecule sensing, and its limitations. Single Biomolecule Detection and Analysis covers single-biomolecule detection and characterization using micro/nanotechnologies and micro/nanofluidic devices, electrical and magnetic detection technologies, microscopy and spectroscopy techniques, single biomolecule optical, and nanopore devices. The text covers key important biosensors-based detection, stochastic optical reconstruction microscopy-based detection, electrochemical detection, metabolic engineering of animal cells, single-molecule intracellular delivery and tracking, terahertz spectroscopy-based detection, total internal reflection fluorescence (TIFR) detection, and Fluorescence Correlation Spectroscopy (FCS) detection. The text will be useful for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. Discussing chemical process, physical process, separation, sensing, imaging, sequencing, and analysis of single-molecule detection, this text will be useful for graduate students and professionals in diverse subject areas including materials science, biomedical engineering, chemical engineering, mechanical engineering, and nanoscience. It covers microscopy and spectroscopy techniques for single-biomolecule detection, analysis, and their biomedical engineering applications.


Nanoscience

Nanoscience

Author: Patrick Boisseau

Publisher: Springer Science & Business Media

Published: 2009-10-14

Total Pages: 1220

ISBN-13: 3540886338

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Nanobiotechnology is a rapidly developing field of research with new applications constantly emerging. This book presents the basics, fundamental results and latest achievements of nanobiotechnological research. It extends as far as promising applications of new nanomaterials and newly discovered nanoeffects. Additionally, it presents a large variety of nanobio-analysis methods.


Process Intensification

Process Intensification

Author: Ramamurthy Nagarajan

Publisher: CRC Press

Published: 2023-04-10

Total Pages: 271

ISBN-13: 1000841529

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Process Intensification: Faster, Better, Cheaper presents basic concepts and applications of process intensification (PI) and links their common effects across processes. It defines two fundamental parameters, PI factor, and Cost Impact (CI) factor, and uses these to analyze various applications where Process Intensification has been carried out. Process Intensification principles have, in the past, been applied to diverse fields, ranging from biodiesel production to offshore processing, and this book unifies these aspects to identify the common factors that drive process enhancements. Each chapter investigates a specific application, discusses the key PI principles, and includes problem sets and examples. The book also provides case studies and realworld examples throughout the chapters. Features: Explores Cost Impact of Process Intensification, and their relative magnitudes, as a universal metric Covers a range of industrial applications, including heat and mass transfer, atomization and comminution, and enhanced oil recovery Discusses the application of Process Intensification for clean coal technology and environmental remediation Includes end-of-chapter problems, examples, and case studies The book is intended for senior undergraduate chemical and mechanical engineering students taking courses in Process Design, Process Optimization, Process Synthesis, and Process Intensification. Instructors will be able to utilize a Solutions Manual and Lecture Slides for their course. The eBook+ version includes the following enhancements: Open-ended essay questions to encourage conceptual thinking and apply new information Pop-up explanations of selected concepts and terms throughout the chapters Interactive definition flashcards that summarize key takeaways at the end of the chapter Quizzes within chapters to help readers refresh their knowledge


Optofluidic Devices and Applications

Optofluidic Devices and Applications

Author: Francisco Yubero

Publisher: MDPI

Published: 2020-12-23

Total Pages: 148

ISBN-13: 3039437178

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Optofluidic devices are of high scientific and industrial interest in chemistry, biology, material science, pharmacy, and medicine. In recent years, they have experienced strong development because of impressive achievements in the synergistic combination of photonics and micro/nanofluidics. Sensing and/or lasing platforms showing unprecedented sensitivities in extremely small analyte volumes, and allowing real-time analysis within a lab-on-a-chip approach, have been developed. They are based on the interaction of fluids with evanescent waves induced at the surface of metallic or photonic structures, on the implementation of microcavities to induce optical resonances in the fluid medium, or on other interactions of the microfluidic systems with light. In this context, a large variety of optofluidic devices has emerged, covering topics such as cell manipulation, microfabrication, water purification, energy production, catalytic reactions, microparticle sorting, micro-imaging, or bio-sensing. Moreover, the integration of these optofluidic devices in larger electro-optic platforms represents a highly valuable improvement towards advanced applications, such as those based on surface plasmon resonances that are already on the market. In this Special Issue, we invited the scientific community working in this rapidly evolving field to publish recent research and/or review papers on these optofluidic devices and their applications.