Microbial Pathogenomics
Microbial Pathogenomics

Author: Hilde de Reuse

Publisher: Karger Medical and Scientific Publishers

Published: 2009-01-01

Total Pages: 224

ISBN-13: 3805591926

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'Microbial Pathogenomics' contains a unique collection of reviews demonstrating how genomics has revolutionized our understanding of virulence, host-adaptation strategies and the evolution of bacterial pathogens. Current technologies - computational tools and functional approaches to genome analysis - are carefully documented and clearly illustrated. These include visualization tools for genome comparison, databases, in silico metabolic reconstructions and function prediction as well as interactomics for the study of protein-protein interactions. The concepts of pan-genomics and reverse vaccinology are introduced as strategies when addressing the challenge presented by bacterial diversity in the prevention and treatment of infectious diseases. The authors explore individual bacterial pathogens and discuss the mechanisms that have contributed to their evolutionary success. Special cases of host adaptation, for example, are illustrated by Helicobacter pylori and 'Mycobacterium tuberculosis' which are human-specific and highly persistent; further bacteria discussed include 'Escherichia coli, Campylobacter, Pseudomonas, Legionella, Bartonella, Burkholderia' and 'Staphylococcus'.'Microbial Pathogenomics' provides the reader with a global view of key aspects and future trends in bacterial pathogenomics and evaluates their impact on the understanding and treatment of infectious diseases. Well illustrated and accessible to both specialists and nonspecialists, it is recommended not only for researchers in microbiology, genomics and biotechnology, but also for lecturers and teachers.

Pathogenomics
Pathogenomics

Author: Jörg Hacker

Publisher: John Wiley & Sons

Published: 2006-12-13

Total Pages: 616

ISBN-13: 352760751X

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The first book on this young, highly dynamic, and expanding field. This comprehensive, interdisciplinary text focuses on those pathogenic bacteria that are of high scientific and public health interest, yet which also display great potential for the development of new diagnostic, prophylactic and therapeutic procedures. The authors cover all aspects of pathogenomics, including methods, genomics and applications. In addition, the ongoing development of genome, transcriptome, proteome and bioinformatic analyses of pathogenic microorganisms and their host interactions makes for a comprehensive introduction to the field of modern genomic analysis. This result is invaluable to researchers and students wishing to gain a general overview of microbial functional genome analysis and pathogenesis, while also representing a good starting point for those new to the area.

Diagnostics to Pathogenomics of Sexually Transmitted Infections
Diagnostics to Pathogenomics of Sexually Transmitted Infections

Author: Sunit Kumar Singh

Publisher: John Wiley & Sons

Published: 2018-12-06

Total Pages: 442

ISBN-13: 1119380847

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Comprehensively explores sexually transmitted diseases, from epidemiology, causative pathogens, clinical impact, and immunology, to management strategies utilizing new strategies of genomics and next-generation diagnostic tools Sexually transmitted infections (STI) are very common worldwide. More than 20 different STIs have been identified, and about 19 million men and women are infected each year in the United States alone. This book looks at the complete picture of common STIs— how they form, evolve, and transmit, as well as how they can be treated and managed with modern techniques, medicines, and tools. Diagnostics to Pathogenomics of Sexually Transmitted Infections runs the spectrum of discussion ranging from introduction of causative pathogen, their pathogenesis to epidemiology, immunology, to anatomy and physiology of human genitalia and management strategies. The book offers in-depth chapter coverage on effect of probiotics on reproductive health; mucosal immunity in sexually transmitted infections; the role of circumcision in preventing STIs; Human Immunodeficiency Virus (HIV); genital herpes; molluscum contagiosum; genital warts; chlaymydia trachomatis; donovanosis; gonorrhoea; treponematoses; genital mycoplasms; bacterial vaginosis; vulvovaginal candidiasis; chlaymydia; scabies; chancroid, yeast infections; and more. Comprehensively compiles most of the major sexually transmitted infections Presents updated information on clinical aspects of sexually transmitted infections Examines the priorities in pathogenesis of human sexually transmitted infections and discusses new strategies of genomics and next-generation diagnostic tools used for detection of such pathogens Explores the future of rapid molecular diagnostic techniques and the challenges posed in the diagnosis of human STIs Includes bench to bedside content that will appeal to both basic and clinical researchers By offering the latest knowledge about recent advances in sexually transmitted infections in an interdisciplinary fashion, Diagnostics to Pathogenomics of Sexually Transmitted Infections is the perfect book for virologists, microbiologists, infectious disease experts, vaccinologists, biomedical researchers, clinicians, pharmacologists, and public health specialists.

Bacterial Population Genetics in Infectious Disease
Bacterial Population Genetics in Infectious Disease

Author: D. Ashley Robinson

Publisher: John Wiley & Sons

Published: 2010-03-16

Total Pages: 448

ISBN-13: 047060011X

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This book is a unique synthesis of the major concepts and methods in bacterial population genetics in infectious disease, a field that is now about 35 yrs old. Emphasis is given to explaining population-level processes that shape genetic variation in bacterial populations and statistical methods of analysis of bacterial genetic data. A "how to" of bacterial population genetics, which covers an extremely large range of organisms Expanding area of science due to high-throughput genome sequencing of bacterial pathogens Covers both fundamental approaches to analyzing bacterial population structures with conceptual background in bacterial population biology Detailed treatment of statistical methods

Microbiology of Urinary Tract Infections
Microbiology of Urinary Tract Infections

Author: Payam Behzadi

Publisher: BoD – Books on Demand

Published: 2019-02-13

Total Pages: 112

ISBN-13: 1789849551

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Generally, in accordance with anatomical characteristics, urinary tract infections (UTIs) and in particular recurrent UTIs occur in women; in contrast, UTIs normally occur in men with different predisposing factors. There are several types of UTIs, including asymptomatic and symptomatic, complicated and uncomplicated, acute and chronic with a diversity of microbial pathogens. In pathogens, virulence factors and genes determine the type and severity of the UTIs. Obviously, UTIs are a huge problem in global public healthcare systems with a wide range of predisposing factors, including gender, microbial agent, the host's immune deficiencies, genetic diseases, catheterization, etc. The recent items determine the microbiology of UTIs. Accurate diagnosis and definitive treatment are the key to UTI reduction.

The Science and Applications of Microbial Genomics
The Science and Applications of Microbial Genomics

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2013-05-02

Total Pages: 429

ISBN-13: 0309268192

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Over the past several decades, new scientific tools and approaches for detecting microbial species have dramatically enhanced our appreciation of the diversity and abundance of the microbiota and its dynamic interactions with the environments within which these microorganisms reside. The first bacterial genome was sequenced in 1995 and took more than 13 months of work to complete. Today, a microorganism's entire genome can be sequenced in a few days. Much as our view of the cosmos was forever altered in the 17th century with the invention of the telescope, these genomic technologies, and the observations derived from them, have fundamentally transformed our appreciation of the microbial world around us. On June 12 and 13, 2012, the Institute of Medicine's (IOM's) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us. Through invited presentations and discussions, participants examined the use of microbial genomics to explore the diversity, evolution, and adaptation of microorganisms in a wide variety of environments; the molecular mechanisms of disease emergence and epidemiology; and the ways that genomic technologies are being applied to disease outbreak trace back and microbial surveillance. Points that were emphasized by many participants included the need to develop robust standardized sampling protocols, the importance of having the appropriate metadata, data analysis and data management challenges, and information sharing in real time. The Science and Applications of Microbial Genomics summarizes this workshop.

Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications
Microbial Diversity in Ecosystem Sustainability and Biotechnological Applications

Author: Tulasi Satyanarayana

Publisher: Springer

Published: 2019-07-17

Total Pages: 639

ISBN-13: 9811383154

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This book discusses microbial diversity in various habitats and environments, its role in ecosystem maintenance, and its potential applications (e.g. biofertilizers, biocatalysts, antibiotics, other bioactive compounds, exopolysaccharides etc.). The respective chapters, all contributed by renowned experts, offer cutting-edge information in the fields of microbial ecology and biogeography. The book explains the reasons behind the occurrence of various biogeographies and highlights recent tools (e.g. metagenomics) that can aid in biogeography studies by providing information on nucleic acid sequence data, thereby directly identifying microorganisms in various habitats and environments. In turn, the book describes how human intervention results in depletion of biodiversity, and how numerous hotspots are now losing their endemic biodiversity, resulting in the loss of many ecologically important microorganisms. In closing, the book underscores the importance of microbial diversity for sustainable ecosystems.

Microbial Transmission
Microbial Transmission

Author: Fernando Baquero

Publisher: John Wiley & Sons

Published: 2019-08-19

Total Pages: 526

ISBN-13: 1683672917

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Microbial transmission, the processes by which microbes transit to new environments, is a significant and broad-reaching concept with applications throughout the biological sciences. This collection of reviews, edited by an international team of experts studying and working across a range of disciplines, explores transmission not just as an idea in disease but as a fundamental biological process that acts in all domains of nature and exerts its force on disparate size scales, from the micro to the macro, and across units of time as divergent as a single bacterial replication cycle and the entire course of evolution. In five sections, this overview Defines the concept of transmission and covers basic processes of transmission, including causality, control strategies, fitness costs, virulence, and selection Presents numerous combinations of transmission scenarios across the bacterial, animal, and human interface Examines transmission as the defining characteristic of infectious disease Presents methods for experimentally verifying and quantifying transmission episodes Concludes with important theoretical and modeling approaches Anyone studying or working in microbial colonization, evolution, pathogenicity, antimicrobial resistance, or public health will benefit from a deeper understanding of Microbial Transmission.

Advances in microbial food safety
Advances in microbial food safety

Author: P. Fratamico

Publisher: Elsevier Inc. Chapters

Published: 2013-07-31

Total Pages: 46

ISBN-13: 0128089822

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Omic technologies, including genomics, proteomics and metabolomics, are used to study pathogen behavior at the molecular level and develop improved pathogen detection and typing systems. Omic technologies analyze complete or nearly complete expressions of cell functions. DNA sequencing has resulted in complete genomes of foodborne pathogens. Omic-based technologies explore biological processes in a quantitative and integrative manner. They facilitate identification of genes and proteins that contribute to survival and persistence in food and other environments, that play a role in pathogenesis and that are targets for detection methods and control strategies. Challenges that remain are performing genomic and proteomic studies in food and other complex matrices and interpreting and analyzing the data produced from these investigations to enhance food safety.

Microbial Genomic Islands in Adaptation and Pathogenicity
Microbial Genomic Islands in Adaptation and Pathogenicity

Author: Indra Mani

Publisher: Springer Nature

Published: 2023-03-31

Total Pages: 369

ISBN-13: 9811993424

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This book elucidates the role of microbial genomic islands (GEIs) in genome stability, plasticity, evolutionary adaptation, and pathogenicity in the bacterial population. The initial chapters of the book present tools, including bioinformatics, artificial intelligence, machine learning, next-generation sequencing, and molecular biology techniques, for the analysis of the genomic islands. The book also discusses the importance of genomic islands in bacterial speciation, acquisition of genes related to resistome, nitrogen fixation, mobilomes, and nutritional fitness and adaptation. It provides recent advances in understanding microbial genomic islands' distribution, evolution, and mechanistic modes of behavior in pathogenic, non-pathogenic, and environmental species. This book is a valuable source for beginners in molecular microbiology, students, researchers, clinicians, stakeholders, and policymakers interested in understanding the role of GEIs in the adaptive evolution of microorganisms. ​