This book provides the latest research and developments in the field of metronomic chemotherapy for breast cancer. It presents the principles and mechanisms of metronomic chemotherapy, preclinical and clinical studies, and the latest developments in drug delivery systems and nanoformulations. The clinical pharmacology of metronomic chemotherapy, including pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions, are also examined. Key Features: Introduces metronomics therapy in the neoadjuvant and adjuvant treatment of breast cancer Explores the potential of metronomics in terms of personalized chemotherapy Present pharmacological bases of metronomic chemotherapy Covers the latest developments in drug delivery systems, nanotechnology, and nanoformulations Discusses antiangiogenic effects and the impact of metronomics on immunity This book is useful for students, researchers, oncologists, pharmacologists, and healthcare experts interested in understanding the clinical potential of metronomic chemotherapy in breast cancer.
This book analyzes all aspects of metronomic chemotherapy, a new approach involving low-dose, long-term, and frequently administered therapy that has preclinical and clinical activity in various tumors. After an opening section on the pharmacological bases of metronomic chemotherapy, including its antiangiogenic effects and impact on immunity, preclinical studies on various classes of drug are discussed. Clinical applications of metronomic chemotherapy in a wide variety of tumors are then addressed in detail, with description of the results of all published studies. The clinical pharmacology of metronomic chemotherapy is also considered in depth, encompassing pharmacokinetics, pharmacogenetics, pharmacoeconomics, and adverse drug reactions. The book closes by describing the role of this therapy in the veterinarian clinic.
As a business leader, you've read dozens of books by the top thought leaders, learning from their research, principles, and tools. Each book dives deep into a specific area of expertise-strategy, execution, cash, people, culture, and leadership. All share powerful concepts on what to do to grow your business. But how do you efficiently unite these tools into a regimen that works for not just one specific area of your business, but for your entire team, company, and life? Metronomics unites top business thought leadership with over twenty years of proven practical experience. The outcome is a prescriptive progressive growth system for every business. In this book, you'll learn how to build a high-performing business team that achieves superior results with ease, speed, and confidence. You'll learn the practical progression that ensures your team is fiercely connected to your strategic execution system. No matter what level you and your team are at right now, Metronomics will meet you where you are-and grow with you to the next level and beyond. The best-kept business secret for the past twenty years, Metronomics will allow your company to win your business Olympics every year, and as a leader, it will set you free.
The Metronome Effect will guide you on your journey to predictable profit. It will ensure the habituation that excellence is derived from is engrained in your organization. Every leader is empowered to set their metric beat to make sure the company is doing everything it needs to do to grow their profit. This book draws on the wisdom of some of the best business minds of our time, as well as the author’s own experiences as a serial entrepreneur, to create a methodology that shows you a practical step-by-step process; how to rhythmically integrate all the crucial parts of your business. Every leader has a metronome—find yours and discover the path to predictable profit. Shannon Byrne Susko has more than twenty years of experience building and leading high-growth technology companies in the financial services industry. She co-founded, served as Chief Executive Officer, and led the sale of two companies in less than six years: Subserveo, Inc. and Paradata Systems Inc. She was recognized as one of Canada’s Top 40 under 40 in 2000, and was awarded the Sarah Kirke Award for Canada’s Leading Women Entrepreneurs in 2006. She currently serves as a corporate director, as well as a leadership coach, helping CEOs and top executives in a variety of industries keep their companies on the path to growth and predictable profit. www.metronome-effect.com “The perfect ‘execution’ book to complement Scaling Up.” Verne Harnish Founder, Gazelles & EO; Author, Scaling Up (Fall 2014), Greatest Business Decisions of All Time, Mastering the Rockefeller Habits “Shannon is a first rate Entrepreneur, Chief Executive, and Business Coach. Through observation of her in each role, directly and through the experience of others working closely with Shannon, the credibility she brings to The Journey to Predictable Profit in a huge asset to fellow Entrepreneurs and Business leaders. Enjoy this book and apply the lessons within.” Keith Cupp President, Gazelles International Coaching Association “An excellent, simple, and proven system to reach strategic clarity and grow your business.” Kaihan Krippendorff Author, Outthink the Competition; CEO, Outthinker
Every company needs a 3HAG--a 3 Year Highly Achievable Goal! The 3HAG WAY is a prescriptive framework that takes the guessing out of your strategy and ensures that you and your whole team are confident in where you are going. It breaks your strategy down into a clear and simple picture--so clear and simple that the whole team will be able to see where the company is going and where it will end up in three years' time. This strategic clarity will align, engage, and empower your team to make confident decisions in order to achieve your 3HAG. You'll find step-by-step instructions to gut out your first 3HAG while building the confidence required to execute with speed toward your goals. The core purpose of this book is to have a significant impact on CEOs, leaders, and their companies and enable them to confidently realize their goals more quickly than they thought possible. And by achieving these goals they will positively impact their families and their communities. Whether you run a team of four, forty or 40,000, the tools and framework in this book will help you articulate your company's strategy in simple terms and create a Strategic Execution System that works. We're going to take each step of the strategy and break it down for you so that you know exactly how to take these steps and why they're critical to achieving your goal.
In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes: namely – to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist’s point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of first approval. The special considerations necessary to address combination drug development, metronomics, biosimilars and breakthrough therapies are also presented.
In this “provocative and persuasive work,” the health advocate reveals the dirty economics of meat—an industry that’s eating into your wallet (Publishers Weekly). Few Americans are aware of the economic system that supports our country’s supply of animal foods. Yet these forces affect us in a number of ways—none of them good. Though we only pay a few dollars per pound of meat at the grocery store, we pay far more in tax-fueled government subsidies—$38 billion more, to be exact. And subsidies are just one layer of meat’s hidden cost. But in Meatonomics, lawyer and sustainability advocate David Robinson Simon offers a path toward lasting solutions. Animal food producers maintain market dominance with artificially low prices, misleading PR, and an outsized influence over legislation. But counteracting these manipulations is easy—with the economic sanity of plant-based foods. In Meatonomics, Simon demonstrates: How government-funded marketing influences what we think of as healthy eating How much of our money is spent to prop up the meat industry How we can change our habits and our country for the better “Spectacularly important.” —John Robbins, author of The Food Revolution “[A] well-researched, passionately written book.” —Publishers Weekly
A world-renowned conductor and composer who has lead most of the major orchestras in North America and Europe, a talented musician who has played under the batons of such luminaries as Toscanini and Walter, and an esteemed arranger, scholar, author, and educator, Gunther Schuller is without doubt a major figure in the music world. Now, in The Compleat Conductor, Schuller has penned a highly provocative critique of modern conducting, one that is certain to stir controversy. Indeed, in these pages he castigates many of this century's most venerated conductors for using the podium to indulge their own interpretive idiosyncrasies rather than devote themselves to reproducing the composer's stated and often painstakingly detailed intentions. Contrary to the average concert-goer's notion (all too often shared by the musicians as well) that conducting is an easily learned skill, Schuller argues here that conducting is "the most demanding, musically all embracing, and complex" task in the field of music performance. Conducting demands profound musical sense, agonizing hours of study, and unbending integrity. Most important, a conductor's overriding concern must be to present a composer's work faithfully and accurately, scrupulously following the score including especially dynamics and tempo markings with utmost respect and care. Alas, Schuller finds, rare is the conductor who faithfully adheres to a composer's wishes. To document this, Schuller painstakingly compares hundreds of performances and recordings with the original scores of eight major compositions: Beethoven's fifth and seventh symphonies, Schumann's second (last movement only), Brahms's first and fourth, Tchaikovsky's sixth, Strauss's "Till Eulenspiegel" and Ravel's "Daphnis et Chloe, Second Suite." Illustrating his points with numerous musical examples, Schuller reveals exactly where conductors have done well and where they have mangled the composer's work. As he does so, he also illuminates the interpretive styles of many of our most celebrated conductors, offering pithy observations that range from blistering criticism of Leonard Bernstein ("one of the world's most histrionic and exhibitionist conductors") to effusive praise of Carlos Kleiber (who "is so unique, so remarkable, so outstanding that one can only describe him as a phenomenon"). Along the way, he debunks many of the music world's most enduring myths (such as the notion that most of Beethoven's metronome markings were "wrong" or "unplayable," or that Schumann was a poor orchestrator) and takes on the "cultish clan" of period instrument performers, observing that many of their claims are "totally spurious and chimeric." In his epilogue, Schuller sets forth clear guidelines for conductors that he believes will help steer them away from self indulgence towards the correct realization of great art. Courageous, eloquent, and brilliantly insightful, The Compleat Conductor throws down the gauntlet to conductors worldwide. It is a controversial book that the music world will be debating for many years to come.
This text highlights seminal discoveries and also provides comprehensive and state-of the-art approach to mouse models of human patient tumors. These areas include training, basic techniques, as well as general troubleshooting. Subsequent chapters focus on the different mouse models of patient tumors including the various strains of immunodeficient mice currently available and the transplantation techniques that can be used as well as state-of-the-art imaging techniques. Practical applications of the models from drug discovery, genome analysis to personalized treatment are also covered. Written by experts in that field, each of these sections address these critical issues. A brief review of the existing literature addressing the particular topic follows in each section. Presently, there is no single source to provide information on technique and uses of mouse models of human patient tumors. Patient-Derived Mouse Models of Cancer will satisfy this need for cancer researchers, oncologists, pharmaceutical and biotechnology industry scientists as well as molecular biologists studying in vivo systems
This contributed book covers all aspects concerning the clinical scenario of breast cancer in young women, providing physicians with the latest information on the topic. Young women are a special subset of patients whose care requires dedicated expertise. The book, written and edited by internationally recognized experts who have been directly involved in the international consensus guidelines for breast cancer in young women, pays particular attention to how the disease and its planned treatment can be effectively communicated to young patients. Highly informative and carefully structured, it provides both theoretical and practice-oriented insight for practitioners and professionals involved in the different phases of treatment, from diagnosis to intervention, to follow-up – without neglecting the important role played by prevention.
