This Research Topic is part of the Methods and Applications in Physiology series. Other titles in this series are: • Methods and Applications in Aquatic Physiology • Methods and Applications in Clinical and Translational Physiology • Methods and Applications in Computational Physiology and Medicine • Methods and Applications in Environmental, Aviation and Space Physiology • Methods and Applications in Exercise Physiology • Methods and Applications in Fractal Physiology • Methods and Applications in Invertebrate Physiology • Methods and Applications in Metabolic Physiology • Methods and Applications in Physio-logging • Methods and Applications in Striated Muscle Physiology • Methods and Applications in Respiratory Physiology • Methods and Applications in Vascular Physiology • New Methods for Red Blood Cell Research and Diagnosis, Volume II • Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters
Edited by physiology instructors who are also active clinicians, Integrated Physiology and Pathophysiology is a one-stop guide to key information you need for early clinical and medical training and practice. This unique, integrated textbook unites these two essential disciplines and focuses on the most relevant aspects for clinical application. A concise, review-like format, tables and diagrams, spaced repetition for effective learning, and self-assessment features help you gain and retain a firm understanding of basic physiology and pathophysiology. Integrated Physiology and Pathophysiology works equally well as a great starting point in your studies and as a review for boards. - Shares the knowledge and expertise of an outstanding editorial team consisting of two practicing clinicians who also teach physiology and pathophysiology at Harvard Medical School, plus a top Harvard medical student. - Provides an integrated approach to physiology and pathophysiology in a concise, bulleted format. Chapters are short and focus on clinically relevant, foundational concepts in clear, simple language. - Employs focused repetition of key points, helping you quickly recall core concepts such as pressure-flow-resistance relationships, ion gradients and action potentials, and mass balance. You'll revisit these concepts in a variety of meaningful clinical contexts in different chapters; this "spaced learning" method of reinforcement promotes deeper and more flexible understanding and application. - Includes Fast Facts boxes that emphasize take-home messages or definitions. - Contains Integration boxes that link physiology and pathophysiology to pharmacology, genetics, and other related sciences. - Presents clinical cases and with signs and symptoms, history, and laboratory data that bring pathophysiology to life. - Features end-of-chapter board-type questions, complete with clear explanations of the answers, to help prepare you for standardized exams. - Evolve Instructor site with an image and test bank as well as PowerPoint slides is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
There is a perception in the scientific community that the discipline of Physiology is in crisis, or at least, in a phase of profound transition and change. At the root of the problem is confusion between objectives (the biological questions to be solved) and the methods and technologies to be applied. Traditionally, ever since Claude Bernard’s concept of the “milieu interieur,” Physiology was an integrative science with the prime concern of studying regulatory mechanisms leading to adaptation and homeostasis in the presence of challenges from a dynamic internal and external environment. This study of control mechanisms can be applied on any level of fu- tion whether subcellular, cellular, and organ, but reaches its highest level of complexity with the functioning of the body as a whole and its interaction with the external environment. This involves the determination of the interaction of genetic with environmental factors and the resulting integrated body adaptation. It might seem obvious that in the pursuit of these questions any appropriate combination of techniques on any organizational level could be used. Yet the advent of molecular techniques has resulted in a preoccupation with the problems and challenges inherent in these techniques, sometimes at the expense of the original perspectives and concepts. The many new mechanisms that have been discovered at the molecular level, as well as their economical exploitation, have contributed to a climate of reductionism.
Modelling Methodology for Physiology and Medicine offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modelling methodology that is widely applicable to physiology and medicine. The book opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. - Builds upon and enhances the readers existing knowledge of modelling methodology and practice - Editors are internationally renowned leaders in their respective fields
"Human anatomy and physiology is a fascinating subject. However, students can be overwhelmed by the complexity, the interrelatedness of concepts from different chapters, and the massive amount of material in the course. Our goal was to create a textbook to guide students on a clearly written and expertly illustrated beginner's path through the human body. An Integrative Approach One of the most daunting challenges that students face in mastering concepts in an anatomy and physiology course is integrating related content from numerous chapters. Understanding a topic like blood pressure, for example, requires knowledge from the chapters on the heart, blood vessels, kidneys, and how these structures are regulated by the nervous and endocrine systems. The usefulness of a human anatomy and physiology text is dependent in part on how successfully it helps students integrate these related concepts. Without this, students are only acquiring what seems like unrelated facts without seeing how they fit into the whole. To adequately explain such complex concepts to beginning students in our own classrooms, we as teachers present multiple topics over the course of many class periods, all the while balancing these detailed explanations with refreshers of content previously covered and intermittent glimpses of the big picture. Doing so ensures that students learn not only the individual pieces, but also how the pieces ultimately fit together. This book represents our best effort to replicate this teaching process. In fact, it is the effective integration of concepts throughout the text that makes this book truly unique from other undergraduate anatomy and physiology texts"--
This volume synthesizes theoretical and practical aspects of both the mathematical and life science viewpoints needed for modeling of the cardiovascular-respiratory system specifically and physiological systems generally. Theoretical points include model design, model complexity and validation in the light of available data, as well as control theory approaches to feedback delay and Kalman filter applications to parameter identification. State of the art approaches using parameter sensitivity are discussed for enhancing model identifiability through joint analysis of model structure and data. Practical examples illustrate model development at various levels of complexity based on given physiological information. The sensitivity-based approaches for examining model identifiability are illustrated by means of specific modeling examples. The themes presented address the current problem of patient-specific model adaptation in the clinical setting, where data is typically limited.
Covering respiratory physiology, this is one in a series of texts which takes a fresh, unique approach to learning physiology in a systems-based curriculum. Each chapter includes clinical correlations, as well as questions that test students' ability to integrate information.
Designed to serve as a primary reference source for researchers and students interested in expanding their research to consider a biopsychosocial approach, this book provides a thorough, state-of-the-art, and user-friendly coverage of basic techniques for measurement of physiological variables in health psychology research.
