Mechanisms of Interleukin 6 Induction by Tumor Necrosis Factor and Interleukin 1
Author: Yihong Zhang
Publisher:
Published: 1990
Total Pages: 254
ISBN-13:
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Author: Yihong Zhang
Publisher:
Published: 1990
Total Pages: 254
ISBN-13:
DOWNLOAD EBOOKAuthor: Kazuwa Nakao
Publisher: Springer
Published: 2015-10-13
Total Pages: 330
ISBN-13: 4431556516
DOWNLOAD EBOOKThis book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.
Author: Robert Dantzer
Publisher: Springer Science & Business Media
Published: 1999-07-31
Total Pages: 334
ISBN-13: 0306461358
DOWNLOAD EBOOKUntil a few years ago, cytokines were only known to immunologists; now these molecules have burst upon neurosciences and permeated several avenues of current research. This book examines the possible role of cytokines in mental depression, based on recent clinical and experimental data, and constitutes the first attempt to make a synthesis between the exciting new developments in cytokine research and their implications for the pathophysiology of mental disorders.
Author: Brenda Kay Smith
Publisher:
Published: 1992
Total Pages: 272
ISBN-13:
DOWNLOAD EBOOKAuthor: J.R. Carey
Publisher: Springer Science & Business Media
Published: 2005-12-16
Total Pages: 168
ISBN-13: 3540273883
DOWNLOAD EBOOKUnderstanding the relationship between frailty and longevity becomes increasingly important as the world continues to age and life expectancy in most countries continues to increase. The articles contained in this book are the outcome of a colloquium sponsored by Fondation IPSEN in which interdisciplinary perspectives were brought to bear on conceptual, empirical and clinical aspects of this relationship.
Author: Nancy J. Rothwell
Publisher: Springer Science & Business Media
Published: 2013-03-09
Total Pages: 216
ISBN-13: 1461596955
DOWNLOAD EBOOKAuthor: Marc Feldmann
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 384
ISBN-13: 1461249961
DOWNLOAD EBOOKLeukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.
Author: Michael Hayes Morgan
Publisher:
Published: 1994
Total Pages: 138
ISBN-13:
DOWNLOAD EBOOKAuthor: L.R. Watkins
Publisher: Springer
Published: 2013-03-08
Total Pages: 248
ISBN-13: 3034887493
DOWNLOAD EBOOKWithin the past few years, it has become recognized that the immune system communicates to the brain. Substances released from activated immune cells (cytokines) stimulate peripheral nerves, thereby signaling the brain and spinal cord that infection/inflammation has occurred. Additionally, peripheral infection/inflammation leads to de novo synthesis and release of cytokines within the brain and spinal cord. Thus, cytokines effect neural activation both peripherally and centrally. Through this communication pathway, cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor markedly alter brain function, physiology and behavior. One important but underrecognized aspect of this communication is the dramatic impact that immune activation has on pain modulation. The purpose of this book is to examine, for the first time, immune-to-brain communication from the viewpoint of its effect on pain processing. It is aimed both at the basic scientist and health care providers, in order to clarify the major role that substances released by immune cells play in pain modulation. This book contains chapters contributed by all of the major laboratories focused on understanding how cytokines modulate pain. These chapters provide a unique vantage point from which to examine this question, as the summarized work ranges from evolutionary approaches across diverse species, to the basics of the immune response, to the effect of cytokines on peripheral and central nervous system sites, to therapeutic potential in humans.
Author: Silvia Gatti
Publisher:
Published: 1994
Total Pages:
ISBN-13: 9789171532879
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