Cardiovascular Soft Tissue Mechanics
Cardiovascular Soft Tissue Mechanics

Author: Stephen C. Cowin

Publisher: Springer Science & Business Media

Published: 2001

Total Pages: 252

ISBN-13: 1402002203

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Cowin (New York Center for Biomedical Engineering) and Humphrey (biomedical engineering, Texas A&M U.) present seven papers that discuss current research and future directions. Topics concern tissues within the cardiovascular system (arteries, the heart, and biaxial testing of planar tissues such as heart valves). Themes include an emphasis on data on the underlying microstructure, especially collagen; the consideration of the fact that both arteries and the heart contain muscle and that there is, therefore, a need to quantify both the active and passive response; constitutive relations for active behavior; and the growth and remodeling of cardiovascular tissues. Of interest to cardiovascular and biomechanics soft tissue researchers, and bioengineers. Annotation copyrighted by Book News, Inc., Portland, OR.

Mechanics of Growing Tissues
Mechanics of Growing Tissues

Author: Jonas Ranft

Publisher:

Published: 2012

Total Pages: 162

ISBN-13:

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In this thesis, we investigate the collective organization of cells by cell division and cell death. The multicellular dynamics of growing tissues is influenced by mechanical conditions and can give rise to cell movements. We develop a continuum description of tissue dynamics, which describes the stress distribution and the cell flow field on large scales. Cell division and apoptosis introduce stress sources that, in general, are anisotropic. We show that the tissue effectively behaves as a viscoelastic fluid with a relaxation time set by the rates of division and apoptosis. If the tissue is confined in a fixed volume, it reaches a state in which division and apoptosis balance. In this state, cells undergo a diffusive motion driven by the stochasticity of division and apoptosis. We calculate the diffusion coefficient and compare our results concerning both diffusion and viscosity to simulations of multicellular systems. Introducing a second material component that accounts for the extracellular fluid, we show that a finite permeability of the tissue gives rise to additional mechanical effects. In the limit of long times, the mechanical response of the tissue to external perturbations is confined to a region of which the size depends on the ratio of tissue viscosity and cell-fluid friction. Last but not least, we study the propagation of an interface between two different cell populations within a tissue. We distinguish two different modes of propagation of the more proliferative population: a diffusive regime in which relative fluxes dominate the expansion, and a propulsive regime in which the proliferation gives rise to dominating convective flows.

Extremely Deformable Structures
Extremely Deformable Structures

Author: Davide Bigoni

Publisher: Springer

Published: 2015-06-05

Total Pages: 300

ISBN-13: 3709118778

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Recently, a new research stimulus has derived from the observation that soft structures, such as biological systems, but also rubber and gel, may work in a post critical regime, where elastic elements are subject to extreme deformations, though still exhibiting excellent mechanical performances. This is the realm of ‘extreme mechanics’, to which this book is addressed. The possibility of exploiting highly deformable structures opens new and unexpected technological possibilities. In particular, the challenge is the design of deformable and bi-stable mechanisms which can reach superior mechanical performances and can have a strong impact on several high-tech applications, including stretchable electronics, nanotube serpentines, deployable structures for aerospace engineering, cable deployment in the ocean, but also sensors and flexible actuators and vibration absorbers. Readers are introduced to a variety of interrelated topics involving the mechanics of extremely deformable structures, with emphasis on bifurcation, instability and nonlinear behavior, both in the quasi-static and dynamic regimes. Essential and up-to-date theoretical, numerical and experimental methodologies are covered, as a tool to progress towards a satisfactory modeling of the nonlinear behavior of structures.

Mechanics of Biological Tissue
Mechanics of Biological Tissue

Author: Gerhard A. Holzapfel

Publisher: Springer Science & Business Media

Published: 2006-06-03

Total Pages: 510

ISBN-13: 354031184X

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The mechanics of biological tissues is a multidisciplinary and rapidly expanding area of research. This book points to important directions combining mechanical sciences with the new developments in biology. It delivers articles on mechanics of tissues at the molecular, cellular, tissue and organ levels.

The Mathematics and Mechanics of Biological Growth
The Mathematics and Mechanics of Biological Growth

Author: Alain Goriely

Publisher: Springer

Published: 2017-05-29

Total Pages: 651

ISBN-13: 038787710X

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This monograph presents a general mathematical theory for biological growth. It provides both a conceptual and a technical foundation for the understanding and analysis of problems arising in biology and physiology. The theory and methods are illustrated on a wide range of examples and applications. A process of extreme complexity, growth plays a fundamental role in many biological processes and is considered to be the hallmark of life itself. Its description has been one of the fundamental problems of life sciences, but until recently, it has not attracted much attention from mathematicians, physicists, and engineers. The author herein presents the first major technical monograph on the problem of growth since D’Arcy Wentworth Thompson’s 1917 book On Growth and Form. The emphasis of the book is on the proper mathematical formulation of growth kinematics and mechanics. Accordingly, the discussion proceeds in order of complexity and the book is divided into five parts. First, a general introduction on the problem of growth from a historical perspective is given. Then, basic concepts are introduced within the context of growth in filamentary structures. These ideas are then generalized to surfaces and membranes and eventually to the general case of volumetric growth. The book concludes with a discussion of open problems and outstanding challenges. Thoughtfully written and richly illustrated to be accessible to readers of varying interests and background, the text will appeal to life scientists, biophysicists, biomedical engineers, and applied mathematicians alike.

Biomechanics of Soft Tissues
Biomechanics of Soft Tissues

Author: Adil Al Mayah

Publisher: CRC Press

Published: 2018-02-21

Total Pages: 189

ISBN-13: 1498766234

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The emerging paradigm of incorporating images and biomechanical properties of soft tissues has proven to be an integral part of the advancement of several medical applications, including image guided radiotherapy and surgery, brachytherapy, and diagnostics. This expansion has resulted in a growing community of medical, science, and engineering professionals applying mechanical principles to address medical concerns. This book is tailored to cover a range of mechanical principles, properties, and applications of soft tissues that have previously been addressed in various journals and "anatomical site-specific" books. Biomechanics of Soft Tissues follows a different approach by offering a simplified overview of widely used mechanical models and measuring techniques of soft tissue parameters. This is followed by an investigation of different medical applications, including: biomechanical aspects of cancerous tumor progressions, radiotherapy treatment, and image guided ultrasound guided interventions. Written by leading scholars and professionals in the field, Biomechanics of Soft Tissues combines engineering and medical expertise, thereby producing an excellent source of information for professionals interested in the theoretical and technological advancements related to soft tissues. The book provides medical professionals with an insight on various modeling approaches, testing techniques, and mechanical characteristics that are frequently used by engineers. Conversely, the presented medical applications provide engineers with a glimpse of amazing medical practices and encourage them to expand their roles in the medical field. Provides a simplified overview of mechanics of soft tissues. Highlights different techniques to measure tissues properties for engineering and medical applications. Contains novel ideas to address roles of mechanics in disease progression and treatment. Presents innovative applications of biomechanics in medical procedures.

Data Book on Mechanical Properties of Living Cells, Tissues, and Organs
Data Book on Mechanical Properties of Living Cells, Tissues, and Organs

Author: Hiroyuki Abe

Publisher: Springer Science & Business Media

Published: 2013-06-29

Total Pages: 443

ISBN-13: 4431658629

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A research project entitled Biomechanics of Structure and Function of Living Cells, Tissues, and Organs was launched in Japan in 1992. This data book presents the original, up-to-date information resulting from the research project, supplemented by some of the important basic data published previously. The aim of collecting the information is to offer accurate and useful data on the mechanical properties of living materials to biomechanical scientists, biomedical engineers, medical scientists, and clinicians. The data are presented in graphs and tables (one type of data per page) arranged in an easily accessible manner, along with details of the origin of the material and the experimental method. Together with its two companion volumes, Biomechanics: Functional Adaptation and Remodeling and Computational Biomechanics, the Data Book on Mechanical Properties of Living Cells, Tissues, and Organs is a timely and valuable contribution to the rapidly growing field of biomechanics.

Visualization and Mathematics III
Visualization and Mathematics III

Author: Hans-Christian Hege

Publisher: Springer Science & Business Media

Published: 2013-11-11

Total Pages: 455

ISBN-13: 3662051052

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A collection of state-of-the-art presentations on visualization problems in mathematics, fundamental mathematical research in computer graphics, and software frameworks for the application of visualization to real-world problems. Contributions have been written by leading experts and peer-refereed by an international editorial team. The book grew out of the third international workshop ‘Visualization and Mathematics’, May 22-25, 2002 in Berlin. The variety of topics covered makes the book ideal for researcher, lecturers, and practitioners.