This volume offers a comprehensive history of the Mount Desert Island Biological Laboratory (MDIBL), one of the major marine laboratories in the United States and a leader in using marine organisms to study fundamental physiological concepts. Beginning with its founding as the Harpswell Laboratory of Tufts University in 1898, David H. Evans follows its evolution from a teaching facility to a research center for distinguished renal and epithelial physiologists. He also describes how it became the site of major advances in cytokinesis, regeneration, cardiac and vascular physiology, hepatic physiology, endocrinology and toxicology, as well as studies of the comparative physiology of marine organisms. Fundamental physiological concepts in the context of the discoveries made at the MDIBL are explained and the social and administrative history of this renowned facility is described.
This monograph is dedicated to the lives and scientific achievements of the physiology pioneers Warren and Margaret Lewis. Their story spans the first half of the 20th century, from their respective educations through early, independent research to joint research from 1910 to 1955. Among the numerous developments they initiated, were the discovery of pinocytosis, the beginnings of video microscopy and the development of the first mammalian tissue cultures. Their research expanded the theoretical knowledge of cell structure and function. On a more practical level, they advanced many laboratory methods, like the first recipes for culture media. The text is beautifully enriched with personal anecdotes about their lives. This is the story of two scientific pioneers in the context of early 20th century biology and physiology. It is an inspiration for senior and aspiring researchers.
"Since the middle of the 19th century, biologists have migrated to the seashore to study marine organisms as a way of understanding life. By the turn of the 20th century, such work was being done inside permanent seaside field stations. The Stazione Zoologica, in Naples, Italy (from 1874), and the Marine Biological Laboratory, in Woods Hole, Massachusetts (from 1888), attracted leaders in many biological fields, and helped establish biology as a modern science. Why Study Biology by the Sea? tells the story of these unique scientific institutions while attempting to answer the contemporary question, "Why study biology by the sea?" The volume examines the origins and value of these places via perspectives that range from cell biology to philosophy of science"--
Naturalists in antiquity worked hard to dispel fanciful ideas about the meaning of living lights, but remained bewildered by them. Even Charles Darwin was perplexed by the chaotic diversity of luminous organisms, which he found difficult to reconcile with his evolutionary theory. It fell to naturalists and scientists to make sense of the dazzling displays of fireflies and other organisms. In Luminous Creatures Michel Anctil shows how mythical perceptions of bioluminescence gradually gave way to a scientific understanding of its mechanisms, functions, and evolution, and to the recognition of its usefulness for biomedical and other applied fields. Following the rise of the modern scientific method and the circumnavigations and oceanographic expeditions of the eighteenth and nineteenth centuries, biologists began to realize the diversity of bioluminescence’s expressions in light organs and ecological imprints, and how widespread it is on the planet. By the end of the nineteenth century an understanding of the chemical nature and physiological control of the phenomenon was at hand. Technological developments led to an explosion of knowledge on the ecology, evolution, and molecular biology of bioluminescence. Luminous Creatures tracks these historical events and illuminates the lives and the trail-blazing accomplishments of the scientists involved. It offers a unique window into the awe-inspiring, phantasmagorical world of light-producing organisms, viewed from the perspectives of casual observers and scientists alike.
Traces historical developments in scientific conceptions of physiology, ecology, behavior, and evolutionary biology during the mid-twentieth century Life Out of Balance focuses on a period in history when new ideas of self-regulation, adaptation, and fitness became central to a variety of biological disciplines. During the decades surrounding World War II, these ideas developed in several quite different contexts and led to greater debates about the merits of such models as applied to larger systems, including society at large. Particularly in its later cybernetic form, homeostasis seemed to provide new ways of discussing balance and regulation that avoided discredited approaches of earlier champions of vitalism and mechanism. It provided a common perspective and terminology for discussing self-regulating “systems,” whether biological, mechanical, or social. Although enormously fruitful and influential, homeostatic perspectives also generated numerous controversies when critics questioned the degree to which biological systems are characterized by balance and self-regulation. Resolving these controversies continues to be a challenge in modern biology. If natural selection constitutes the first law of biology, scientists who champion homeostasis as a theoretical model claim that it is a second law, equally important and closely related to the first. Such claims notwithstanding, homeostasis has generated a series of controversies since it was formalized by Walter Cannon in the late 1920s. Critics contended that Cannon took a too-optimistic view of life, not only ignoring pathological deviations from normality but also failing to adequately explain the ability of living things to respond adaptively to environmental challenges. Underlying these controversies was the unresolved problem of integrating physiology and other areas of functional biology with the emerging evolutionary synthesis of Mendelian genetics and Darwinian natural selection. The physiological idea of homeostasis as the adaptive “fit” between the organism and its environment and the Darwinian idea of adaptation and fitness in terms of reproductive success might seem to be complementary in an unproblematic way, but historically they have had an uneasy relationship.
Reprints of articles written by workers at the Weir Mitchell Station of the Mount Desert Island Biological Laboratory and published in various journals.
