The first guide to providing systematic anticoagulation care in inpatient settings, this new resource will be welcomed by all pharmacists who practice in or are developing, implementing and maintaining an inpatient anticoagulation service; a review of anticoagulant medications and case examples of issues commonly encountered. Each chapter contains tools, references, policies, competency exams, etc that are included on a companion CD-ROM.
Although highly effective in preventing thromboembolic events, the safe management of anticoagulant therapy continues to be a major challenge, requiring constant monitoring and coordinated models of patient-centered care. Anticoagulation Therapy: A Clinical Practice Guide, Second Edition, helps take the guesswork out of managing these therapies and provides essential recommendations. This revised and expanded edition includes: Extensive new information on the direct oral anticoagulants (DOACs) Expanded information on anticoagulant reversal and expanded use of prothrombin complex concentrates New chapters on the use of anticoagulants in special patient populations, the use of anticoagulants in patients with mechanical devices, anticoagulation care delivery standards, regulatory issues, and more Four new appendices on the effect of DOACs on chemotherapy, nutritional influences, types of central nervous system hemorrhage, and use of anticoagulation in patients with coagulopathies
The first practical guide for hospitalists on the use of anticoagulants in hospitalized patients This edited volume provides a comprehensive overview of the vital topic of anticoagulation in the hospital setting. Designed specifically for use by hospital-based clinicians and associated hospital-based staff, this fully evidence-based book addresses the most commonly used anticoagulant agents, the latest advances in anticoagulation drugs, and primary indications for their use at therapeutic levels. This thorough, easy-to-use reference summarizes the most important guidelines and medical literature on anticoagulation. It features a careful review of the epidemiology and treatment of complications associated with anticoagulants. Unique topics include transition of care and practical strategies for developing and implementing quality improvement programs to enhance the administration and safety of anticoagulants. This concise resource also covers: Antiplatelet medications The treatment and prevention of venous thromboembolism in medical patients Venous thromboembolism prophylaxis in surgical patients Peri-operative management of oral anticoagulants and antiplatelet agents Prevention of cardioembolic stroke Antithrombotics for ischemic stroke Antithrombotic therapy for non-ST elevation acute coronary syndrome Hemorrhagic complications of anticoagulants in hospitalized patients Heparin-induced thrombocytopenia Hospitalists and other members of the patient care team will find that Inpatient Anticoagulation answers their questions with dependable and timely information.
In addition to acting as a training guide for pharmacists, pharmacy residents and pharmacy students who seek to practice in areas associated with patients on anticoagulant therapy, the information presented within highlights the growing role of the pharmacist in these contexts. Readers will find useful information on anticoagulant management across all pharmacy practice areas, including the inpatient, ambulatory, emergency services and transitions of care settings. Particular attention is given to summarizing best practices and providing ‘real world’ examples of ways in which pharmacists can be involved in anticoagulation management and the impact of such involvement. In the first major section of the book, each chapter focuses on the role of the pharmacist in the management of medication with a specific type of anticoagulants (e.g. warfarin, heparin and target-specific oral agents) in various healthcare settings. A broader overview of the clinical management of anticoagulation therapy is provided in the second major section, including descriptions of the role of pharmacists in assessing venous thromboembolism risk, ensuring patients receive appropriate prophylactic therapy, and monitoring outcomes.
This book is open access under a CC BY 4.0 license. This quick-reference handbook offers a concise and practical review of key aspects of the treatment of ST-segment elevation myocardial infarction (STEMI) in the era of primary percutaneous coronary intervention (PPCI). In the context of STEMI, PPCI is the preferred mode of emergency revascularization. Access to PPCI is rapidly increasing and is now routinely practiced in both general and specialist hospitals and there has been a recent emphasis on developing STEMI networks to enhance and expedite the referral pathway. This coupled with concurrent developments to enhance the safety and efficacy of the PPCI procedure has heralded an era where STEMI interventions are increasingly considered an important subspecialty within interventional cardiology. Written by leading cardiologists who have been instrumental in the adoption of PPCI in their respective institutions, the book provides junior and senior cardiologists alike with insightful and thought-provoking tips and tricks to enhance the success of PPCI procedures, which may in turn translate into direct improvements in outcomes. The book is also relevant for healthcare providers and emergency department physicians.
Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.
The definitive guide to the knowledge and skills necessary to practice Hospital Medicine Presented in full color and enhanced by more than 700 illustrations, this authoritative text provides a background in all the important clinical, organizational, and administrative areas now required for the practice of hospital medicine. The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Each chapter opens with boxed Key Clinical Questions that are addressed in the text and hundreds of tables encapsulate important information. Case studies demonstrate how to apply the concepts covered in the text directly to the hospitalized patient. Principles and Practice of Hospital Medicine is divided into six parts: Systems of Care: Introduces key issues in Hospital Medicine, patient safety, quality improvement, leadership and practice management, professionalism and medical ethics, medical legal issues and risk management, teaching and development. Medical Consultation and Co-Management: Reviews core tenets of medical consultation, preoperative assessment and management of post-operative medical problems. Clinical Problem-Solving in Hospital Medicine: Introduces principles of evidence-based medicine, quality of evidence, interpretation of diagnostic tests, systemic reviews and meta-analysis, and knowledge translations to clinical practice. Approach to the Patient at the Bedside: Details the diagnosis, testing, and initial management of common complaints that may either precipitate admission or arise during hospitalization. Hospitalist Skills: Covers the interpretation of common “low tech” tests that are routinely accessible on admission, how to optimize the use of radiology services, and the standardization of the execution of procedures routinely performed by some hospitalists. Clinical Conditions: Reflects the expanding scope of Hospital Medicine by including sections of Emergency Medicine, Critical Care, Geriatrics, Neurology, Palliative Care, Pregnancy, Psychiatry and Addiction, and Wartime Medicine.
The available parenteral and oral anticoagulants have a large clinical use. Understanding biochemistry of anticoagulants may help to improve therapeutic strategies. Resistance to vitamin K antagonist drugs might be a problem for rodent populations. Patients who have thrombogenic risk factors should be anticoagulated. The need for cardiac implantable electronic devices is increasing, and there is a substantial number of patients who are on oral anticoagulant therapy. Prothrombin complex concentrate and other plasma concentrates are useful to deal with over-coagulated situations. The efficacy and safety of non-vitamin K antagonist oral anticoagulants have been proven in large phase III trials. The real-world data suggest even better outcomes with these agents compared to vitamin K antagonists.
