Love and loyalties get tested in another gripping LA drama from Lucy Broadbent. Pearl Sash lives the dream. Adoring husband, perfect child, and a glamorous Hollywood Hills mansion. Shame how perfect gets boring, isn't it? Cue the re-entrance of Brett. Dangerous, sexy Brett who she married years ago, and who left her the second his own Hollywood star was rising. Now he's back, wanting to start over. No man ever made her feel so bad. No man ever made her feel so good! Will Pearl make the right decision to get her own Hollywood ending?
Discover New Methods for Dealing with High-Dimensional DataA sparse statistical model has only a small number of nonzero parameters or weights; therefore, it is much easier to estimate and interpret than a dense model. Statistical Learning with Sparsity: The Lasso and Generalizations presents methods that exploit sparsity to help recover the underl
A New York Times Notable Book of the Year Winner of the Mountains and Plains Book Seller's Association Award "Sprawling in scope. . . . Mr. Egan uses the past powerfully to explain and give dimension to the present." --The New York Times "Fine reportage . . . honed and polished until it reads more like literature than journalism." --Los Angeles Times "They have tried to tame it, shave it, fence it, cut it, dam it, drain it, nuke it, poison it, pave it, and subdivide it," writes Timothy Egan of the West; still, "this region's hold on the American character has never seemed stronger." In this colorful and revealing journey through the eleven states west of the 100th meridian, Egan, a third-generation westerner, evokes a lovely and troubled country where land is religion and the holy war between preservers and possessors never ends. Egan leads us on an unconventional, freewheeling tour: from America's oldest continuously inhabited community, the Ancoma Pueblo in New Mexico, to the high kitsch of Lake Havasu City, Arizona, where London Bridge has been painstakingly rebuilt stone by stone; from the fragile beauty of Idaho's Bitterroot Range to the gross excess of Las Vegas, a city built as though in defiance of its arid environment. In a unique blend of travel writing, historical reflection, and passionate polemic, Egan has produced a moving study of the West: how it became what it is, and where it is going. "The writing is simply wonderful. From the opening paragraph, Egan seduces the reader. . . . Entertaining, thought provoking." --The Arizona Daily Star Weekly "A western breeziness and love of open spaces shines through Lasso the Wind. . . . The writing is simple and evocative." --The Economist
This is the first book to be released on Lasso that provides a step by step how to guide to creating Web solutions. The focus is on teaching essential elements of Lasso for dynamic Web content.
The Panama Canal's untold history—from the Panamanian point of view. Sleuth and scholar Marixa Lasso recounts how the canal’s American builders displaced 40,000 residents and erased entire towns in the guise of bringing modernity to the tropics. The Panama Canal set a new course for the modern development of Central America. Cutting a convenient path from the Atlantic to the Pacific oceans, it hastened the currents of trade and migration that were already reshaping the Western hemisphere. Yet the waterway was built at considerable cost to a way of life that had characterized the region for centuries. In Erased, Marixa Lasso recovers the history of the Panamanian cities and towns that once formed the backbone of the republic. Drawing on vast and previously untapped archival sources and personal recollections, Lasso describes the canal’s displacement of peasants, homeowners, and shop owners, and chronicles the destruction of a centuries-old commercial culture and environment. On completion of the canal, the United States engineered a tropical idyll to replace the lost cities and towns—a space miraculously cleansed of poverty, unemployment, and people—which served as a convenient backdrop to the manicured suburbs built exclusively for Americans. By restoring the sounds, sights, and stories of a world wiped clean by U.S. commerce and political ambition, Lasso compellingly pushes back against a triumphalist narrative that erases the contribution of Latin America to its own history.
"Ted Lasso" is an American comedy TV series that premiered on August 14, 2020, on Apple TV+. The show is created by Bill Lawrence, Jason Sudeikis, Joe Kelly, and Brendan Hunt, and stars Jason Sudeikis as the titular character, Ted Lasso. Ted is a cheerful and optimistic American football coach who is hired by a struggling English Premier League team, AFC Richmond, to manage their soccer team, despite having no prior experience in soccer. The series follows the misadventures of Ted Lasso, his assistant coach, Coach Beard, and the rest of the team, as they try to turn Richmond's fortunes around. The show has received widespread critical acclaim for its engaging storyline, witty writing, and brilliant acting. Critics have praised Jason Sudeikis' performance as Ted Lasso, with many calling it one of the best performances of his career. The show has been praised for its uplifting and positive message, with many viewers finding it to be a much-needed escape from the stresses of daily life. "Ted Lasso" has also been lauded for its diverse cast of characters and big-hearted approach to storytelling, making it one of the most beloved TV shows of recent times.
An accessible and engaging journey through the philosophical themes and concepts of Ted Lasso Ted Lasso and Philosophy explores the hidden depths beneath the vibrant veneer of AppleTV’s breakout, award-winning sitcom. Blending philosophical sophistication with winsome appreciation of this feel-good comedy, the collection features 20 original essays canvassing the breadth of the series and carefully considering the ideas it presents, including the goal of competition, the role of mental health, sportsmanship, revenge versus justice, the importance of friendship, the imperative of respect for persons, humility, leadership, identity, character growth, courage, journalistic ethics, belief, forgiveness, what love looks like, and just how evil tea is. In a nod to the show’s many literary allusions, the compilation concludes with a whimsical appendix that catalogs the books most significant to Ted Lasso’s themes and characters. If football is life, as Dani Rojas fondly repeats, then this book’s a fitting primer. Covers the full breadth of the original Ted Lasso series, including the third season Explores every major character and all of the show's significant subplots and elements Written in the spirit of the show, with in-jokes that will appeal to Ted Lasso fans Features an introduction that guides readers through the book’s materials Includes Beard's Bookshelf, a bibliography of the most significant books shown or alluded to in the series Ted Lasso and Philosophy is for the curious, not judgmental. Sport is quite the metaphor, and we can’t wait to unpack it with you.
Model selection and forecasting in stress tests can be facilitated using machine learning techniques. These techniques have proved robust in other fields for dealing with the curse of dimensionality, a situation often encountered in applied stress testing. Lasso regressions, in particular, are well suited for building forecasting models when the number of potential covariates is large, and the number of observations is small or roughly equal to the number of covariates. This paper presents a conceptual overview of lasso regressions, explains how they fit in applied stress tests, describes its advantages over other model selection methods, and illustrates their application by constructing forecasting models of sectoral probabilities of default in an advanced emerging market economy.
Lasso peptides form a growing family of fascinating ribosomally-synthesized and post-translationally modified peptides produced by bacteria. They contain 15 to 24 residues and share a unique interlocked topology that involves an N-terminal 7 to 9-residue macrolactam ring where the C-terminal tail is threaded and irreversibly trapped. The ring results from the condensation of the N-terminal amino group with a side-chain carboxylate of a glutamate at position 8 or 9, or an aspartate at position 7, 8 or 9. The trapping of the tail involves bulky amino acids located in the tail below and above the ring and/or disulfide bridges connecting the ring and the tail. Lasso peptides are subdivided into three subtypes depending on the absence (class II) or presence of one (class III) or two (class I) disulfide bridges. The lasso topology results in highly compact structures that give to lasso peptides an extraordinary stability towards both protease degradation and denaturing conditions. Lasso peptides are generally receptor antagonists, enzyme inhibitors and/or antibacterial or antiviral (anti-HIV) agents. The lasso scaffold and the associated biological activities shown by lasso peptides on different key targets make them promising molecules with high therapeutic potential. Their application in drug design has been exemplified by the development of an integrin antagonist based on a lasso peptide scaffold. The biosynthesis machinery of lasso peptides is therefore of high biotechnological interest, especially since such highly compact and stable structures have to date revealed inaccessible by peptide synthesis. Lasso peptides are produced from a linear precursor LasA, which undergoes a maturation process involving several steps, in particular cleavage of the leader peptide and cyclization. The post-translational modifications are ensured by a dedicated enzymatic machinery, which is composed of an ATP-dependent cysteine protease (LasB) and a lactam synthetase (LasC) that form an enzymatic complex called lasso synthetase. Microcin J25, produced by Escherichia coli AY25, is the archetype of lasso peptides and the most extensively studied. To date only around forty lasso peptides have been isolated, but genome mining approaches have revealed that they are widely distributed among Proteobacteria and Actinobacteria, particularly in Streptomyces, making available a rich resource of novel lasso peptides and enzyme machineries towards lasso topologies.
