Edible Oleogels
Edible Oleogels

Author: Alejandro G. Marangoni

Publisher: Elsevier

Published: 2015-08-24

Total Pages: 350

ISBN-13: 163067009X

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In an effort to provide alternatives to trans and saturated fats, scientists have been busy modifying the physical properties of oils to resemble those of fats. In this fashion, many food products requiring a specific texture and rheology can be made with these novel oil-based materials without causing significant changes to final product quality. The major approach to form these materials is to incorporate specific molecules (polymers, amphiphiles, waxes) into the oil components that will alter the physical properties of the oil so that its fluidity will decrease and the rheological properties will be similar to those of fats. These new oilbased materials are referred to as oil gels, or "oleogels," and this emerging technology is the focus of many scientific investigations geared toward helping decrease the incidence of obesity and cardiovascular disease. - Presents a novel strategy to eliminate trans fats from our diets and avoid excessive amounts of saturated fat by structuring oil to make it behave like crystalline fat - Reviews recent advances in the structuring of edible oils to form new mesoscale and nanoscale structures, including nanofibers, mesophases, and functionalized crystals and crystalline particles - Identifies evidence on how to develop trans fat free, low saturate functional shortenings for the food industry that could make a major impact on the health characteristics of the foods we consume

Oral Drug Absorption
Oral Drug Absorption

Author: Jennifer B. Dressman

Publisher: CRC Press

Published: 2016-04-19

Total Pages: 432

ISBN-13: 1420077341

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Oral Drug Absorption, Second Edition thoroughly examines the special equipment and methods used to test whether drugs are released adequately when administered orally. The contributors discuss methods for accurately establishing and validating in vitro/in vivo correlations for both MR and IR formulations, as well as alternative approaches for MR an

Nanoparticulate Drug Delivery Systems
Nanoparticulate Drug Delivery Systems

Author: Deepak Thassu

Publisher: CRC Press

Published: 2007-03-30

Total Pages: 317

ISBN-13: 1000654745

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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Oral Lipid-Based Formulations
Oral Lipid-Based Formulations

Author: David J. Hauss

Publisher: CRC Press

Published: 2007-06-08

Total Pages: 370

ISBN-13: 1420017268

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Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Preclinical Evaluation of Lipid-Based Nanosystems
Preclinical Evaluation of Lipid-Based Nanosystems

Author: Ana Catarina Silva

Publisher: Mdpi AG

Published: 2021-07-31

Total Pages: 352

ISBN-13: 9783036515502

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The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC)), nanoemulsions, and liposomes, among others, is widespread. Several researchers have described the advantages of different applications of these nanosystems. For instance, they can increase the targeting and bioavailability of drugs, improving therapeutic effects. Their use in the cosmetic field is also promising, owing to their moisturizing properties and ability to protect labile cosmetic actives. Thus, it is surprising that only a few lipid-based nanosystems have reached the market. This can be explained by the strict regulatory requirements of medicines and the occurrence of unexpected in vivo failure, which highlights the need to conduct more preclinical studies. Current research is focused on testing the in vitro, ex vivo, and in vivo efficacy of lipidbased nanosystems to predict their clinical performance. However, there is a lack of method validation, which compromises the comparison between different studies. This book brings together the latest research and reviews that report on in vitro, ex vivo, and in vivo preclinical studies using lipid-based nanosystems. Readers can find up-todate information on the most common experiments performed to predict the clinical behavior of lipid-based nanosystems. A series of 15 research articles and a review are presented, with authors from 15 different countries, which demonstrates the universality of the investigations that have been carried out in this area.

Nanocosmetics
Nanocosmetics

Author: Jean Cornier

Publisher: Springer

Published: 2019-06-14

Total Pages: 365

ISBN-13: 3030165736

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This book addresses the application of nanotechnology to cosmetics. Edited by three respected experts in the field, the book begins with a general overview of the science behind cosmetics and skin care today, and of the status quo of nanotechnology in cosmetics. Subsequent chapters provide detailed information on the different nanoparticles currently used in cosmetics; the production and characterization of nanoparticles and nanocosmetics; and regulatory, safety and commercialization aspects. Given its scope, the book offers an indispensable guide for scientists in academia and industry, technicians and students, as well as a useful resource for decision-makers in the field and consumer organizations. Chapter 6 of this book is available open access under a CC BY 4.0 licence at link.springer.com.

Amorphous Solid Dispersions
Amorphous Solid Dispersions

Author: Navnit Shah

Publisher: Springer

Published: 2014-11-21

Total Pages: 702

ISBN-13: 1493915983

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This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid dispersions, ASD technologies, excipients for stabilizing amorphous solid dispersions such as polymers, and ASD manufacturing technologies, including spray drying, hot melt extrusion, fluid bed layering and solvent-controlled micro-precipitation technology (MBP). Each technology is illustrated by specific case studies. In addition, dedicated sections cover analytical tools and technologies for characterization of amorphous solid dispersions, the prediction of long-term stability, and the development of suitable dissolution methods and regulatory aspects. The book also highlights future technologies on the horizon, such as supercritical fluid processing, mesoporous silica, KinetiSol®, and the use of non-salt-forming organic acids and amino acids for the stabilization of amorphous systems. Amorphous Solid Dispersions: Theory and Practice is a valuable reference to pharmaceutical scientists interested in developing bioavailable and therapeutically effective formulations of poorly soluble molecules in order to advance these technologies and develop better medicines for the future.

Lymphatic Transport of Drugs
Lymphatic Transport of Drugs

Author: William N. Charman

Publisher: CRC Press

Published: 1992-04-22

Total Pages: 348

ISBN-13: 9780849363948

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Lymphatic Transport of Drugs provides a thorough review of the determinants that affect the uptake and delivery of drugs and xenobiotics to the lymphatics. Factors affecting the transport and delivery of lipophilic drugs through the lymph after oral administration, lymphatic transport of polar drugs and macromolecules after gastrointestinal dosing, transport of drugs into the lymph after parenteral administration, and particulate drug delivery systems are among the topics examined in this volume. Lymphatic Transport of Drugs is primarily intended for pharmaceutical scientists who are attempting to alter the delivery of current therapeutic agents through formulation of prodrugs, as well as for researchers designing new drugs for lymph delivery.

Excipient Applications in Formulation Design and Drug Delivery
Excipient Applications in Formulation Design and Drug Delivery

Author: Ajit S Narang

Publisher: Springer

Published: 2015-10-07

Total Pages: 700

ISBN-13: 3319202065

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In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.

Lipid Nanoparticles: Production, Characterization and Stability
Lipid Nanoparticles: Production, Characterization and Stability

Author: Rohan Shah

Publisher: Springer

Published: 2014-08-28

Total Pages: 105

ISBN-13: 3319107119

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​What are lipid nanoparticles? How are they structured? How are they formed? What techniques are best to characterize them? How great is their potential as drug delivery systems? These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear and understandable understanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. A comprehensive description of the current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems. Nanoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. The work provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure. Current thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed. The many techniques for production, including the author’s own variant of microwave heating, are fully discussed. Techniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity. Finally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. This work appeals to students of colloid science, practitioners of research into drug delivery and academics alike.