This introductory text presents the use of statistical methods as an integral part of biological investigation, yet one whose superficial complexities have deterred many biologists from using them. The author argues that the difficulties, such as they are, do not lie in mathematical manipulation, but in grasping a few simple, but unfamiliar concepts. He emphasizes the need for precisely defining problems and for careful selection of the most appropriate methods - a wide range of which are described and illustrated. Each chapter ends with a set of problems which are intended to help the student gain practical experience. No previous knowledge is assumed, and the student is encouraged to develop a competent and critical approach to analysing numerical data. In this second edition, the scope of the book has been extended, problems have been solved in a more satisfactory way, and a greater number of illustrative examples have been added.
Even though an understanding of experimental design and statistics is central to modern biology, undergraduate and graduate students studying biological subjects often lack confidence in their numerical abilities. Allaying the anxieties of students, Introduction to Statistics for Biology, Third Edition provides a painless introduction to the subject while demonstrating the importance of statistics in contemporary biological studies. New to the Third Edition More detailed explanation of the ideas of elementary probability to simplify the rationale behind hypothesis testing, before moving on to simple tests An emphasis on experimental design and data simulation prior to performing an experiment A general template for carrying out statistical tests from hypothesis to interpretation Worked examples and updated Minitab analyses and graphics Downloadable resources contains a free trial version of Minitab Using Minitab throughout to present practical examples, the authors emphasize the interpretation of computer output. With its nontechnical approach and practical advice, this student-friendly introductory text lays the foundation for the advanced study of statistical analysis.
This illustrated textbook for biologists provides a refreshingly clear and authoritative introduction to the key ideas of sampling, experimental design, and statistical analysis. The author presents statistical concepts through common sense, non-mathematical explanations and diagrams. These are followed by the relevant formulae and illustrated by w
"A thorough grounding in statistics is necessary for a career in any experimental science, but many students find themselves intimidated by the subject. Hampton and Havel have written this text with these students in mind. While providing the theory and assumptions necessary for a deep understanding of statistics, they make it approachable and keep it relevant to the interests of biology students. Their examples and exercises show how to choose the appropriate statistical method for a particular hypothesis and how to execute that method using problems encountered by real-world biologists. The second edition has been ambitiously updated and reorganized, facilitating clearer connections between topics and improving clarity of those that are logically distinct."--BOOK JACKET.
Introductory Statistics 2e provides an engaging, practical, and thorough overview of the core concepts and skills taught in most one-semester statistics courses. The text focuses on diverse applications from a variety of fields and societal contexts, including business, healthcare, sciences, sociology, political science, computing, and several others. The material supports students with conceptual narratives, detailed step-by-step examples, and a wealth of illustrations, as well as collaborative exercises, technology integration problems, and statistics labs. The text assumes some knowledge of intermediate algebra, and includes thousands of problems and exercises that offer instructors and students ample opportunity to explore and reinforce useful statistical skills. This is an adaptation of Introductory Statistics 2e by OpenStax. You can access the textbook as pdf for free at openstax.org. Minor editorial changes were made to ensure a better ebook reading experience. Textbook content produced by OpenStax is licensed under a Creative Commons Attribution 4.0 International License.
Advances in computers and biotechnology have had a profound impact on biomedical research, and as a result complex data sets can now be generated to address extremely complex biological questions. Correspondingly, advances in the statistical methods necessary to analyze such data are following closely behind the advances in data generation methods. The statistical methods required by bioinformatics present many new and difficult problems for the research community. This book provides an introduction to some of these new methods. The main biological topics treated include sequence analysis, BLAST, microarray analysis, gene finding, and the analysis of evolutionary processes. The main statistical techniques covered include hypothesis testing and estimation, Poisson processes, Markov models and Hidden Markov models, and multiple testing methods. The second edition features new chapters on microarray analysis and on statistical inference, including a discussion of ANOVA, and discussions of the statistical theory of motifs and methods based on the hypergeometric distribution. Much material has been clarified and reorganized. The book is written so as to appeal to biologists and computer scientists who wish to know more about the statistical methods of the field, as well as to trained statisticians who wish to become involved with bioinformatics. The earlier chapters introduce the concepts of probability and statistics at an elementary level, but with an emphasis on material relevant to later chapters and often not covered in standard introductory texts. Later chapters should be immediately accessible to the trained statistician. Sufficient mathematical background consists of introductory courses in calculus and linear algebra. The basic biological concepts that are used are explained, or can be understood from the context, and standard mathematical concepts are summarized in an Appendix. Problems are provided at the end of each chapter allowing the reader to develop aspects of the theory outlined in the main text. Warren J. Ewens holds the Christopher H. Brown Distinguished Professorship at the University of Pennsylvania. He is the author of two books, Population Genetics and Mathematical Population Genetics. He is a senior editor of Annals of Human Genetics and has served on the editorial boards of Theoretical Population Biology, GENETICS, Proceedings of the Royal Society B and SIAM Journal in Mathematical Biology. He is a fellow of the Royal Society and the Australian Academy of Science. Gregory R. Grant is a senior bioinformatics researcher in the University of Pennsylvania Computational Biology and Informatics Laboratory. He obtained his Ph.D. in number theory from the University of Maryland in 1995 and his Masters in Computer Science from the University of Pennsylvania in 1999. Comments on the first edition: "This book would be an ideal text for a postgraduate course...[and] is equally well suited to individual study.... I would recommend the book highly." (Biometrics) "Ewens and Grant have given us a very welcome introduction to what is behind those pretty [graphical user] interfaces." (Naturwissenschaften) "The authors do an excellent job of presenting the essence of the material without getting bogged down in mathematical details." (Journal American Statistical Association) "The authors have restructured classical material to a great extent and the new organization of the different topics is one of the outstanding services of the book." (Metrika)
Biostatistics with R is designed around the dynamic interplay among statistical methods, their applications in biology, and their implementation. The book explains basic statistical concepts with a simple yet rigorous language. The development of ideas is in the context of real applied problems, for which step-by-step instructions for using R and R-Commander are provided. Topics include data exploration, estimation, hypothesis testing, linear regression analysis, and clustering with two appendices on installing and using R and R-Commander. A novel feature of this book is an introduction to Bayesian analysis. This author discusses basic statistical analysis through a series of biological examples using R and R-Commander as computational tools. The book is ideal for instructors of basic statistics for biologists and other health scientists. The step-by-step application of statistical methods discussed in this book allows readers, who are interested in statistics and its application in biology, to use the book as a self-learning text.
An understanding of statistics and experimental design is essential for life science studies, but many students lack a mathematical background and some even dread taking an introductory statistics course. Using a refreshingly clear and encouraging reader-friendly approach, this book helps students understand how to choose, carry out, interpret and report the results of complex statistical analyses, critically evaluate the design of experiments and proceed to more advanced material. Taking a straightforward conceptual approach, it is specifically designed to foster understanding, demystify difficult concepts and encourage the unsure. Even complex topics are explained clearly, using a pictorial approach with a minimum of formulae and terminology. Examples of tests included throughout are kept simple by using small data sets. In addition, end-of-chapter exercises, new to this edition, allow self-testing. Handy diagnostic tables help students choose the right test for their work and remain a useful refresher tool for postgraduates.
A thorough understanding of biology, no matter which subfield, requires a thorough understanding of statistics. As in previous editions, Havel and Hampton (with new co-author Scott Meiners) ground students in all essential methods of descriptive and inferential statistics, using examples from different biological sciences. The authors have retained the readable, accessible writing style popular with both students and instructors. Pedagogical improvements new to this edition include concept checks in all chapters to assist students in active learning and code samples showing how to solve many of the book's examples using R. Each chapter features numerous practice and homework exercises, with larger data sets available for download at waveland.com.
