Intravital Imaging of Dynamic Bone and Immune Systems
Intravital Imaging of Dynamic Bone and Immune Systems

Author: Masaru Ishii

Publisher: Humana

Published: 2019-06-06

Total Pages: 175

ISBN-13: 9781493985449

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This detailed volume presents a number of chapters that will aid researchers in jumping the hurdle preventing the popularization of advanced intravital imaging technology usage, namely the complicated experimental protocols. Leading researchers undertaking imaging studies in the field of bone and immune systems have contributed the chapters that aim to guide readers through these complex methodologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Intravital Imaging of Dynamic Bone and Immune Systems: Methods and Protocols will serve as an idea guide for general readers in order to establish and perform these experiments by their own.

Make Life Visible
Make Life Visible

Author: Yoshiaki Toyama

Publisher: Springer Nature

Published: 2019-10-02

Total Pages: 285

ISBN-13: 9811379084

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This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Osteoimmunology
Osteoimmunology

Author: Joseph Lorenzo

Publisher: Academic Press

Published: 2015-09-23

Total Pages: 380

ISBN-13: 0128006277

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Osteoimmunology: Interactions of the Immune and Skeletal Systems, Second Edition, explores the advancements that have been made in the field during the last 40 years, including valuable information on our understanding of the interactions between hematopoietic, immune, and bone cells, now known as the field of osteoimmunology. This comprehensive work offers the most extensive summaries of research trends in the field and their translation into new therapeutics. Early chapters deal with the development of osteoblasts, osteoclasts, hematopoietic stem cells, T and B-lymphocytes, and communications between these cellular elements, while later sections contain discussions of the signaling pathways by which RANKL influences osteoclast development and function. Subsequent chapters explore the effects that estrogen has on bone and the immune system, the development of pathologic conditions, and the growing research around osteoporosis, Paget’s disease, the genetics of bone disease, and bone cancer metastasis. Explains the intricate interaction between the immune system and bone Features detailed discussions of the key cellular and molecular mechanisms governing the homeostasis of the individual systems Facilitates greater understanding of osteoimmunologic networks, their environments, and how this understanding leads to better treatments for human diseases involving both systems

Advances in Intravital Microscopy
Advances in Intravital Microscopy

Author: Roberto Weigert

Publisher: Springer

Published: 2014-11-12

Total Pages: 425

ISBN-13: 9401793611

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This is the first book entirely dedicated to Intravital Microscopy. It provides the reader with a broad overview of the main applications of Intravital Microscopy in various areas of the biomedical field. The book contains accurate descriptions of the state of the art methodologies used to image various organs at different level of resolution, ranging from whole tissue down to sub-cellular structures. Moreover, it is an extremely valuable guide to scientists that want to adopt this powerful technique and do not have experience with animal models and microscopy.

National Institute of Allergy and Infectious Diseases, NIH
National Institute of Allergy and Infectious Diseases, NIH

Author: Vassil St. Georgiev

Publisher: Springer Science & Business Media

Published: 2010-07-29

Total Pages: 434

ISBN-13: 1607615126

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National Institute of Allergy and Infectious Diseases, NIH: Volume III: Intramural Research contains a broad overview of the research activity of the NIAID intramural scientists working in the Division of Intramural Research (DIR) and the Vaccine Research Center (VRC), both in the Bethesda campus, and the Rocky Mountains Research Laboratories. Each of these laboratories employs scientists internationally recognized as leaders in their fields of biomedical research. This volume focuses on individual research contributions by internationally known scientists doing research in the NIAID laboratories.

Bone Marrow Environment
Bone Marrow Environment

Author: Marion Espéli

Publisher: Humana

Published: 2021-06-01

Total Pages: 340

ISBN-13: 9781071614242

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This volume brings together classical and cutting-edge protocols on the spatio-temporal study of the cellular subsets constituting the bone and the marrow in both mouse and human. Chapters details methods on bone marrow (BM) ecosystem, to label, sort, analyse, and culture specific cell subsets as well as techniques allowing the evaluation of the function of some of the cellular elements of the BM. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Bone Marrow Environment: Methods and Protocols aims to help new investigators to pursue the characterization of the BM microenvironment in the coming years.

Second Harmonic Generation Imaging
Second Harmonic Generation Imaging

Author: Francesco S. Pavone

Publisher: Taylor & Francis

Published: 2016-04-19

Total Pages: 465

ISBN-13: 1439849153

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Second-harmonic generation (SHG) microscopy has shown great promise for imaging live cells and tissues, with applications in basic science, medical research, and tissue engineering. Second Harmonic Generation Imaging offers a complete guide to this optical modality, from basic principles, instrumentation, methods, and image analysis to biomedical a

Imaging from Cells to Animals In Vivo
Imaging from Cells to Animals In Vivo

Author: Margarida Barroso

Publisher: CRC Press

Published: 2020-12-03

Total Pages: 371

ISBN-13: 1351704508

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Imaging from Cells to Animals In Vivo offers an overview of optical imaging techniques developed over the past two decades to investigate biological processes in live cells and tissues. It comprehensively covers the main imaging approaches used as well as the application of those techniques to biological investigations in preclinical models. Among the areas covered are cell metabolism, receptor-ligand interactions, membrane trafficking, cell signaling, cell migration, cell adhesion, cytoskeleton and other processes using various molecular optical imaging techniques in living organisms, such as mice and zebrafish. Features Brings together biology and advanced optical imaging techniques to provide an overview of progress and modern methods from microscopy to whole body imaging. Fills the need for a comprehensive view of application-driven development and use of new tools to ask new biological questions in the context of a living system. Includes basic chapters on key methods and instrumentation, from fluorescence microscopy and imaging to endoscopy, optical coherence tomography and super-resolution imaging. Discusses approaches at different length scales and biomedical applications to the study of single cell, whole organ, and whole organism behavior. Addresses the impact on discovery, such as cellular function as implicated in human disease and translational medicine, for example in cancer diagnosis.