Anatomy and Physiology
Author: J. Gordon Betts
Publisher:
Published: 2013-04-25
Total Pages: 0
ISBN-13: 9781947172807
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Colonic Motility
Author: Sushil K. Sarna
Publisher: Biota Publishing
Published: 2010-11-01
Total Pages: 159
ISBN-13: 1615041516
DOWNLOAD EBOOKThree distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood.
Regulation of Gastrointestinal Mucosal Growth
Author: Rao N. Jaladanki
Publisher: Biota Publishing
Published: 2016-11-30
Total Pages: 150
ISBN-13: 1615047352
DOWNLOAD EBOOKThe mammalian gastrointestinal mucosa is a rapidly self-renewing tissue in the body, and its homeostasis is preserved through the strict regulation of epithelial cell proliferation, growth arrest, and apoptosis. The control of the growth of gastrointestinal mucosa is unique and, compared with most other tissue in the body, complex. Mucosal growth is regulated by the same hormones that alter metabolism in other tissues, but the gastrointestinal mucosa also responds to host events triggered by the ingestion and presence of food within the digestive tract. These gut hormones and peptides regulate the growth of the exocrine pancreas, gallbladder epithelium, and the mucosa of the oxyntic gland region of the stomach and the small and large intestines. Luminal factors, including nutrients or other dietary factors, secretions, and microbes that occur within the lumen and distribute over a proximal-to-distal gradient, are also crucial for maintenance of normal gut mucosal regeneration and could explain the villous-height-crypt-depth gradient and variety of adaptation, since these factors are diluted, absorbed, and destroyed as they pass down the digestive tract. Recently, intestinal stem cells, cellular polyamines, and noncoding RNAs are shown to play an important role in the regulation of gastrointestinal mucosal growth under physiological and various pathological conditions. In this book, we highlight key issues and factors that control gastrointestinal mucosal growth and homeostasis, with special emphasis on the mechanisms through which epithelial renewal and apoptosis are regulated at the cellular and molecular levels.
Clinical Imaging of the Small Intestine
Author: Hans Herlinger
Publisher: Springer Science & Business Media
Published: 2001-11-30
Total Pages: 596
ISBN-13: 9780387953885
DOWNLOAD EBOOKDesigned as a guide to clinical radiology of the small intestine, the book addresses the pertinent aspects of gastrointestinal radiology, specifically the problems of technique and interpretation that confront the radiologist with interest in the small intestine.
Intestinal Failure
Author: Alan N. Langnas
Publisher: John Wiley & Sons
Published: 2009-01-21
Total Pages: 416
ISBN-13: 1405195797
DOWNLOAD EBOOKIntestinal failure is a challenging, emerging field that has beenthe subject of much research and debate in recent years and hasonly recently become widely accepted as a distinct clinicalsyndrome. This comprehensive book provides an in-depth review ofscientific theory and clinical practice relating to intestinalfailure with specific emphasis on assessment and management as partof a multidisciplinary team. Compiled by an internationallyrecognised editorial team, the book provides a practical how-toguide to the management of adult and pediatric patients withintestinal failure, focusing on quality-of-life issues that are atthe heart of patient care. World experts from centers of excellence share their clinicalexperience and expertise, offering the first ever authoritativeresource on intestinal failure All aspects of patient management are covered, from diagnosisand medical and surgical management (including transplantation) tonutritional consideration and psychosocial aspects of care Numerous illustrations, flow diagrams and summary boxescomplement the text and emphasize important concepts, providing anaccessible approach to this complex field This landmark book is essential reading for anygastroenterologists, surgeons, transplant teams or clinicalnutritionists involved in the care of patients with intestinalfailure.
The Intestine
Author: Ahmed El-Hashash
Publisher: Academic Press
Published: 2021-06-15
Total Pages: 206
ISBN-13: 0128212713
DOWNLOAD EBOOKThe intestine is among the leading organs, in which several cutting edge in vitro and in vivo research tools and approaches have recently been developed and used to investigate stem cell biology/function, and the potential applications of stem cells in the treatment of intestinal diseases. These cutting-edge research tools and approaches involve human and murine organoid cultures, genetic editing in vitro and in vivo, human induced pluripotent cell (iPS cell) models of disease, haploid cells for genetic as well as compound screening paradigms, genetically engineered mice, and stem cell transplantation to cure diseases. Stem Cell Innovation in Health and Disease: Volume 1: The Intestine contains two major sections describing cutting edge research for understanding stem cell functions in the intestine, and for developing methods to bring stem cells from bench to bedside; respectively. Each section includes insights ranging from using mouse and human organoid cultures, genetic editing in vitro and in vivo, and human induced pluripotent cells (iPSCs) to study stem cell functions and model intestinal diseases, through the cutting-edge research, including the potential application of iPSCs, ESCs and blood stem cells (stem cell transplants) in the treatment of intestinal diseases/disorders. This volume, therefore, discusses the fact-based promise of stem cells and regenerative medicine in the intestine in the real world. - Provides intensive scientific background and most recent information on cutting edge research to understand intestinal stem cell functions and develop methods to bring stem cells from bench to bedside for different intestinal diseases - Analyzes the current state, opportunities, and challenges of innovative technologies and stem cells from bench to bed, including organoids and the CRISPR gene editing system in the intestine - Contains two major sections describing cutting-edge research for understanding stem cell functions and for developing methods specific to the intestine
Intestinal Stomas
Author: Peter Cataldo
Publisher: CRC Press
Published: 2004-03-29
Total Pages: 335
ISBN-13: 9780824747077
DOWNLOAD EBOOKThis text features coverage of basic intestinal physiology, as well as the management of complications and unusual problems. Additional chapters and fully updated material consider laparoscopic-assisted colostomy and methods of urinary diversion in stoma management.
Atlas of Intestinal Stomas
Author: Victor W. Fazio
Publisher: Springer Science & Business Media
Published: 2012-02-11
Total Pages: 296
ISBN-13: 0387788514
DOWNLOAD EBOOKDesigned to provide a highly visual reference for surgeons and other members of the patient management team, Atlas of Intestinal Stomas is based on the 1967 gold standard text, Turnbull and Weakly’s Atlas of Intestinal Stomas. Additions include chapters on anatomy and physiology, biliary stomas, pediatric ostomies, the continent ileostomy, urostomy, laparoscopic stoma construction, stomas in trauma surgery, stomas for antegrade continence enema, percutaneous ostomies, and quality of life. There are also sections on ileostomy, colostomy, enterostomal therapy and on the management of complications of stomas such as management of the high output ostomy, enterocutaneous fistula, parastomal hernia, prolapse, and skin conditions. The Cleveland Clinic pioneered the entire practice of ostomies, beginning in 1858 and continuing to this day as the world’s leading academic and clinical center. The editors and contributors are all current or former Cleveland Clinic physicians and instructors. The fundamental focus of the book is not only how to install ostomies, but how to avoid complications and how to treat complications when they arise. Atlas of Intestinal Stomas will be of great value to colorectal and general surgeons, both in practice and in training.
Open Abdomen
Author: Federico Coccolini
Publisher: Springer
Published: 2018-06-06
Total Pages: 281
ISBN-13: 3319480723
DOWNLOAD EBOOKThis book is the first available practical manual on the open abdomen. Practicing physicians, surgeons, anesthesiologists, nurses, and physiotherapists will find in it a ready source of information on all aspects of open abdomen management in a wide variety of settings. The coverage includes, for example, the open abdomen in trauma, intra-abdominal sepsis, and acute pancreatitis, step-by-step descriptions of different techniques with the aid of high-quality color figures, guidance on potential complications and their management, and features of management in different age groups. The book contents illustrate the most recent innovations and drawing upon a thorough and up-to-date literature review. Useful tips and tricks are highlighted, and the book is designed to support in daily decision making. The authors include worldwide opinion leaders in the field, guaranteeing the high scientific value of the content.
Gastrointestinal Motility
Author: D. Grundy
Publisher: Springer Science & Business Media
Published: 2012-12-06
Total Pages: 188
ISBN-13: 9401093555
DOWNLOAD EBOOKThe basis of this book is a ten-lecture course on the control of gastrointesti nal motility given each year to the final year undergraduate students in Physiology at Sheffield University. A naive thought led me to believe that the conversion of my lecture notes into the present book would be a relatively easy task. I now know differently. As there is no equivalent undergraduate course elsewhere that I know of, it would be dishonest of me to claim this book to be an undergraduate text. The comprehensive way in which I have dealt with the subject, together with the inclusion of the most up-to-date material, make the book more relevant to postgraduate students of physiology, medicine and related sciences who require an introduction to the field of gastrointestinal motility and its control. I have, however, attempted to present the current concepts on the physiological mechanisms regulating motility in a way which under graduates, as well as postgraduates, will find readable, informative and, hopefully, enjoyable.
