This text focuses on the physics of fluid transport in micro- and nanofabricated liquid-phase systems, with consideration of gas bubbles, solid particles, and macromolecules. This text was designed with the goal of bringing together several areas that are often taught separately - namely, fluid mechanics, electrodynamics, and interfacial chemistry and electrochemistry - with a focused goal of preparing the modern microfluidics researcher to analyse and model continuum fluid mechanical systems encountered when working with micro- and nanofabricated devices. This text serves as a useful reference for practising researchers but is designed primarily for classroom instruction. Worked sample problems are included throughout to assist the student, and exercises at the end of each chapter help facilitate class learning.
The first book offering a global overview of fundamental microfluidics and the wide range of possible applications, for example, in chemistry, biology, and biomedical science. As such, it summarizes recent progress in microfluidics, including its origin and development, the theoretical fundamentals, and fabrication techniques for microfluidic devices. The book also comprehensively covers the fluid mechanics, physics and chemistry as well as applications in such different fields as detection and synthesis of inorganic and organic materials. A useful reference for non-specialists and a basic guideline for research scientists and technicians already active in this field or intending to work in microfluidics.
The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products.
This exceptional book is concerned with the application of fractals and chaos, as well as other concepts from nonlinear dynamics to biomedical phenomena. Herein we seek to communicate the excitement being experienced by scientists upon making application of these concepts within the life sciences. Mathematical concepts are introduced using biomedical data sets and the phenomena being explained take precedence over the mathematics. In this new edition what has withstood the test of time has been updated and modernized; speculations that were not borne out have been expunged and the breakthroughs that have occurred in the intervening years are emphasized. The book provides a comprehensive overview of a nascent theory of medicine, including a new chapter on the theory of complex networks as they pertain to medicine.
Now in its Third Edition, the Artech House bestseller, Fundamentals and Applications of Microfluidics, provides engineers and students with the most complete and current coverage of this cutting-edge field. This revised and expanded edition provides updated discussions throughout and features critical new material on microfluidic power sources, sensors, cell separation, organ-on-chip and drug delivery systems, 3D culture devices, droplet-based chemical synthesis, paper-based microfluidics for point-of-care, ion concentration polarization, micro-optofluidics and micro-magnetofluidics. The book shows how to take advantage of the performance benefits of microfluidics and serves as an instant reference for state-of-the-art microfluidics technology and applications. Readers find discussions on a wide range of applications, including fluid control devices, gas and fluid measurement devices, medical testing equipment, and implantable drug pumps. Professionals get practical guidance in choosing the best fabrication and enabling technology for a specific microfluidic application, and learn how to design a microfluidic device. Moreover, engineers get simple calculations, ready-to-use data tables, and rules of thumb that help them make design decisions and determine device characteristics quickly. addressed at the design stage to reduce the risk of failures in the field is presented. The book includes technical details of all state-of-the-art Li-on energy storage subsystems and their requirements, and provides a system designer a single resource detailing all of the common issues navigated when using Li-ion batteries to reduce the risk of field failures. The book details the various industry standards that are applicable to the subsystems of Li-ion energy storage systems and how the requirements of these standards may impact the design of their system. Checklists are included to help readers evaluate their own battery system designs and identify gaps in the designs that increase the risk of field failures. The book is packed with numerous examples of issues that have caused field failures and how a proper design/assembly process could have reduced the risk of these failures.
In the present book, various applications of microfluidics and nanofluidics are introduced. Microfluidics and nanofluidics span a broad array of disciplines including mechanical, materials, and electrical engineering, surface science, chemistry, physics and biology. Also, this book deals with transport and interactions of colloidal particles and biomolecules in microchannels, which have great importance to many microfluidic applications, such as drug delivery in life science, microchannel heat exchangers in electronic cooling, and food processing industry. Furthermore, this book focuses on a detailed description of the thermal transport behavior, challenges and implications that involve the development and use of HTFs under the influence of atomistic-scale structures and industrial applications.
This second edition contains extensive new coverage of both microfluidics and computational fluid dynamics, systematically demonstrating CFD through detailed examples using FlowLab and COMSOL Multiphysics. The chapter on turbulence has been extensively revised to address more complex and realistic challenges, including turbulent mixing and recirculating flows"--Jacket.
The Chemical Engineer's Practical Guide to Fluid Mechanics: Now Includes COMSOL Multiphysics 5 Since most chemical processing applications are conducted either partially or totally in the fluid phase, chemical engineers need mastery of fluid mechanics. Such knowledge is especially valuable in the biochemical, chemical, energy, fermentation, materials, mining, petroleum, pharmaceuticals, polymer, and waste-processing industries. Fluid Mechanics for Chemical Engineers: with Microfluidics, CFD, and COMSOL Multiphysics 5, Third Edition, systematically introduces fluid mechanics from the perspective of the chemical engineer who must understand actual physical behavior and solve real-world problems. Building on the book that earned Choice Magazine's Outstanding Academic Title award, this edition also gives a comprehensive introduction to the popular COMSOL Multiphysics 5 software. This third edition contains extensive coverage of both microfluidics and computational fluid dynamics, systematically demonstrating CFD through detailed examples using COMSOL Multiphysics 5 and ANSYS Fluent. The chapter on turbulence now presents valuable CFD techniques to investigate practical situations such as turbulent mixing and recirculating flows. Part I offers a clear, succinct, easy-to-follow introduction to macroscopic fluid mechanics, including physical properties; hydrostatics; basic rate laws; and fundamental principles of flow through equipment. Part II turns to microscopic fluid mechanics: Differential equations of fluid mechanics Viscous-flow problems, some including polymer processing Laplace's equation; irrotational and porous-media flows Nearly unidirectional flows, from boundary layers to lubrication, calendering, and thin-film applications Turbulent flows, showing how the k-ε method extends conventional mixing-length theory Bubble motion, two-phase flow, and fluidization Non-Newtonian fluids, including inelastic and viscoelastic fluids Microfluidics and electrokinetic flow effects, including electroosmosis, electrophoresis, streaming potentials, and electroosmotic switching Computational fluid mechanics with ANSYS Fluent and COMSOL Multiphysics Nearly 100 completely worked practical examples include 12 new COMSOL 5 examples: boundary layer flow, non-Newtonian flow, jet flow, die flow, lubrication, momentum diffusion, turbulent flow, and others. More than 300 end-of-chapter problems of varying complexity are presented, including several from University of Cambridge exams. The author covers all material needed for the fluid mechanics portion of the professional engineer's exam. The author's website (fmche.engin.umich.edu) provides additional notes, problem-solving tips, and errata. Register your book for convenient access to downloads, updates, and/or corrections as they become available. See inside book for details.
This internationally authored volume presents major findings, concepts, and methods of behavioral neuroscience coordinated with their simulation via neural networks. A central theme is that biobehaviorally constrained simulations provide a rigorous means to explore the implications of relatively simple processes for the understanding of cognition (complex behavior). Neural networks are held to serve the same function for behavioral neuroscience as population genetics for evolutionary science. The volume is divided into six sections, each of which includes both experimental and simulation research: (1) neurodevelopment and genetic algorithms, (2) synaptic plasticity (LTP), (3) sensory/hippocampal systems, (4) motor systems, (5) plasticity in large neural systems (reinforcement learning), and (6) neural imaging and language. The volume also includes an integrated reference section and a comprehensive index.
