Immunotherapies Towards HIV Cure
Author: Carolina Garrido
Publisher: Frontiers Media SA
Published: 2021-07-08
Total Pages: 153
ISBN-13: 2889669815
DOWNLOAD EBOOKRead and Download eBook Full
Author: Carolina Garrido
Publisher: Frontiers Media SA
Published: 2021-07-08
Total Pages: 153
ISBN-13: 2889669815
DOWNLOAD EBOOKAuthor: Mirko Paiardini
Publisher: Frontiers Media SA
Published: 2020-05-15
Total Pages: 157
ISBN-13: 2889637166
DOWNLOAD EBOOKAuthor: Guido Silvestri
Publisher: Springer
Published: 2018-10-11
Total Pages: 253
ISBN-13: 303002816X
DOWNLOAD EBOOKThis volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.
Author: Linqi Zhang
Publisher: Springer
Published: 2018-07-20
Total Pages: 326
ISBN-13: 981130484X
DOWNLOAD EBOOKThis book provides a comprehensive review of the major barriers to HIV cure and vaccine. It covers the fundamental virology and immunology leading to HIV transmission, protection from infection and long term HIV persistence on antiretroviral therapy. In addition, strategies being tested to eliminate persistent HIV and the rational design of vaccines to induce protective immunity are covered. This book also discusses the challenges related to the design of clinical trials for testing the safety and efficacy of these innovative approaches. This book will provide a systematic overview and also discuss controversial issues for researchers in virology and immunology, as well as practicing physicians, and scientists in the pharmaceutical industry.
Author: Michael S. Saag
Publisher:
Published: 2001
Total Pages: 54
ISBN-13:
DOWNLOAD EBOOKAuthor: Constantinos Petrovas
Publisher: Frontiers Media SA
Published: 2019-02-11
Total Pages: 186
ISBN-13: 2889457583
DOWNLOAD EBOOKCurrently, more than 36 million people are infected with HIV. Although the introduction of highly active anti-retroviral therapy (HAART) has led to substantial advances in the clinical management of HIV infected individuals, HAART cannot completely eliminate the virus. This is because CD4 T helper cells, harboring the virus, remain dormant reservoirs. These reservoirs are difficult to measure and are present even in HAART-treated HIV infected individuals with undetectable levels of HIV in the blood. A growing body of studies has revealed follicular helper (Tfh) CD4 T cells, a highly differentiated CD4 T cell population localized in immunologically sanctuary sites (follicle/germinal center), as a major reservoir of HIV. The present Frontiers in Immunology eBook compiles 16 timely review articles focusing on the dynamics of major follicular immune cell types in HIV/SIV infection and their potential role for disease pathogenesis and the viral persistence in the lymph node. This eBook provides a comprehensive presentation of recent published work on lymph node and especially Tfh cell dynamics in HIV infection and we hope that it will be useful for our further understanding of how such dynamics affect the interplay between virus and host as well as for the discovery of novel therapeutic targets in the fight against HIV.
Author: Ulrich R. Hengge
Publisher:
Published: 2004
Total Pages: 144
ISBN-13: 9783895997020
DOWNLOAD EBOOKTremendous progress in the understanding of the immune pathogenesis of HIV disease has been made in the last two decades like in no other field of science ever before. Besides the inhibition of viral replication with highly active antiretroviral therapy (HAART) immunoreconstitution remains an important mainstay to be achieved in the battle against HIV. Intensive research has led to worldwide phase-III studies of immunotreatment of HIV infection such as the SILCAAT and ESPRIT trials to boost existing immune responses and to restore the immune system leading to the control of viral replication. The science and practical management of immunotherapy of HIV patients is described by famous experts from immunology, virology, gene therapy, dermatology, and clinical medicine.
Author: Renee Marije Van Der Sluis
Publisher: Frontiers Media SA
Published: 2021-04-07
Total Pages: 111
ISBN-13: 2889666662
DOWNLOAD EBOOKAuthor: Taisuke Izumi
Publisher: Frontiers Media SA
Published: 2022-01-17
Total Pages: 132
ISBN-13: 2889741060
DOWNLOAD EBOOKAuthor: Sudhir Gupta
Publisher: Springer Science & Business Media
Published: 2013-11-11
Total Pages: 618
ISBN-13: 1489901914
DOWNLOAD EBOOKLeading experts provide the only comprehensive book examining all aspects of immune response and immune-based treatments for HIV infection. Contributions, divided into three sections, discuss basic mechanisms, immunopathogenesis of HIV infection, and immune-based therapies. Researchers thoroughly review vaccine-including prospects of T cell vaccine-and gene therapy for HIV infection. Additional topics include organization of HIV genes, the role of co-receptors in signaling of lymphocytes, and biological response modifiers. This reference is designed for basic and clinical researchers, internists, pediatricians, infectious disease specialists, neuropathologists, oncologists, and rheumatologists.