Immunology of Silicones
Immunology of Silicones

Author: Michael Potter

Publisher: Springer Science & Business Media

Published: 2012-12-06

Total Pages: 423

ISBN-13: 3642852262

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This issue of Current Topics in Microbiology and Immunology records the proceedings of a Workshop on the Immunology of Sili cones held at the Natcher Conference Center, National Institutes of Health, Bethesda, Maryland, March 13 and 14, 1995. A large num ber of investigators from North America and Europe met to discuss available data on how the immune system responds to silicones and related materials. Some aspects of this field are controversial. Nonetheless, the meeting was marked by a civil and open ex change of scientific information and divergent interpretations, re flecting the traditions of scientific communication. Each invited participant was asked to submit an article sum marizing his/her presentation. Most of the papers are published as submitted, with only editorial changes to conform with the guide lines given to each contributor or revisions to clarify aspects of the paper. The papers should not be regarded as peer-reviewed publi cations. This preface will attempt to outline some of the immu nological areas of investigation relating to silicones.

Safety of Silicone Breast Implants
Safety of Silicone Breast Implants

Author: Institute of Medicine

Publisher: National Academies Press

Published: 2000-01-06

Total Pages: 559

ISBN-13: 0309132754

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The Dow Corning case raised serious questions about the safety of silicone breast implants and about larger issues of medical device testing and patient education. Safety of Silicone Breast Implants presents a well-documented, thoughtful exploration of the safety of these devices, drawing conclusions from the available research base and suggesting further questions to be answered. This book also examines the sensitive issues surrounding women's decisions about implants. In reaching conclusions, the committee reviews: The history of the silicone breast implant and the development of its chemistry. The wide variety of U.S.-made implants and their regulation by the Food and Drug Administration. Frequency and consequences of local complications from implants. The evidence for and against links between implants and autoimmune disorders, connective tissue disease, neurological problems, silicone in breast milk, or a proposed new syndrome. Evidence that implants may be associated with lower frequencies of breast cancer. Safety of Silicone Breast Implants provides a comprehensive, well-organized review of the science behind one of the most significant medical controversies of our time.

Injection-Induced Breast Siliconomas
Injection-Induced Breast Siliconomas

Author: Gustavo Emilio Schenone

Publisher: Springer Nature

Published: 2019-11-21

Total Pages: 319

ISBN-13: 3030241165

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Although there is a current ban in many countries on the injection of liquid silicone, paraffin or polyacrylamide hydrogels or other gel or liquid materials into the breasts for the purpose of increasing size, there are still a large number of non-professionals who use these injections and offer them as a cheap alternative to plastic surgery. The results, at first, may seem cosmetically favorable for the patient, but these injections often lead to painful complications like mastitis (inflammation of the mammary gland) and can make it incredibly difficult to diagnose breast cancer early. Many patients suffer delayed complications that force them to seek expert care for corrective and reconstructive surgery. This book, the culmination of decades of research, aims to serve the surgeon faced with these complications, offering a detailed step-by-step guide of the pathology from clinical diagnosis and imaging studies to the different surgical and reconstructive procedures for reconstruction. As there is no clinical management consensus or international guideline, Injection-Induced Breast Siliconomas: Clinical Implications, Evaluation and Treatment fills the gap in the literature and encourages more research. Previously published in Spanish in 2017 under the title "Siliconomas Mamarios por Inyeccion: Clinica, Diagnostico y Tratamiento", this English translation is a true re-edition of the original version with added updates for the English-speaking audience.

Mosaic of Autoimmunity
Mosaic of Autoimmunity

Author: Carlo Perricone

Publisher: Academic Press

Published: 2019-02-13

Total Pages: 728

ISBN-13: 012814307X

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The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis.

Vaccines and Autoimmunity
Vaccines and Autoimmunity

Author: Yehuda Shoenfeld

Publisher: John Wiley & Sons

Published: 2015-07-07

Total Pages: 394

ISBN-13: 1118663438

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In light of the discovery of Autoimmune Syndrome Induced by Adjuvants, or ASIA, Vaccines and Autoimmunity explores the role of adjuvants – specifically aluminum in different vaccines – and how they can induce diverse autoimmune clinical manifestations in genetically prone individuals. Vaccines and Autoimmunity is divided into three sections; the first contextualizes the role of adjuvants in the framework of autoimmunity, covering the mechanism of action of adjuvants, experimental models of adjuvant induced autoimmune diseases, infections as adjuvants, the Gulf War Syndrome, sick-building syndrome (SBS), safe vaccines, toll-like receptors, TLRS in vaccines, pesticides as adjuvants, oil as adjuvant, mercury, aluminum and autoimmunity. The following section reviews literature on vaccines that have induced autoimmune conditions such as MMR and HBV, among others. The final section covers diseases in which vaccines were known to be the solicitor – for instance, systemic lupus erythematosus – and whether it can be induced by vaccines for MMR, HBV, HCV, and others. Edited by leaders in the field, Vaccines and Autoimmunity is an invaluable resource for advanced students and researchers working in pathogenic and epidemiological studies.

Autoantibodies
Autoantibodies

Author: Yehuda Shoenfeld

Publisher: Newnes

Published: 2013-11-26

Total Pages: 917

ISBN-13: 0444593772

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Autoimmune diseases are characterized by the occurrence of antibodies reacting with self-constituents of the body. The fully updated third edition of Autoantibodies is an in-depth review of the main autoantibodies identified up to now, with particular emphasis on those that display a diagnostic or prognostic clinical value. The new edition covers recent scientific advances, diagnostic techniques, and therapeutic technologies. Each chapter is focused on a single family of autoantibodies. This important reference contains historical notes, definitions, origins and sources of antigens recognized genetic associations, mediated pathogenic mechanisms, methods of detection, as well as clinical utility (disease prevalence and association, diagnostic value, sensitivity and specificity, prognostic value). This is an ideal reference for anyone involved in the field of autoimmune diseases. - Presents all known, important autoantibodies in a single source, focusing on the antibodies needed for autoimmune disorder diagnosis - Includes clinical applications for each autoantibody along with general information - Organized by disease and disorder type, by autoantibody family, and completely cross-referenced