Human Serum Albumin (HSA)
Human Serum Albumin (HSA)

Author: Travis Stokes

Publisher: Nova Science Publishers

Published: 2015

Total Pages: 0

ISBN-13: 9781634829632

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Human Serum Albumin (HSA) is the most abundant plasma protein. It has been widely used for drug delivery systems and has recently emerged as a versatile carrier for therapeutic agents against diabetes, cancer and infectious diseases. This book provides an overview of the expanding field of preclinical and clinical applications and developments that use albumin as a carrier of drug delivery systems. The authors' discuss the properties of drug binding sites within the structure of HSA, discuss new possibilities for the therapeutic potential of HSA and analyze recently reported HSA-drug complexes including HSA-antibody conjugates. Novel investigations on the applications of albumin fusion proteins are discussed as well, with a focus on tumor targeting and intracellular delivery. Other chapters examine the different aspects of albumin glycation and oxidation, the changes in the structure of human serum albumin determined from infrared spectroscopy and a review of CAPIDAN, a special fluorescent dye, which attaches to drug binding sites of human serum albumin.

Albumin in Medicine
Albumin in Medicine

Author: Masaki Otagiri

Publisher: Springer

Published: 2016-11-01

Total Pages: 279

ISBN-13: 9811021163

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This book presents a comprehensive overview of medical and pharmaceutical applications of human serum albumin (HSA), with updates on structural aspects of albumin from the perspectives of X-ray crystallography and NMR, endogenous and exogenous ligand binding of albumin in various pathological conditions, and genetic variants and their phenotypes. Rapid progress and development of its applications have resulted in outstanding results for which albumin has clearly been proven to be a robust biomaterial. Contributions from leading international experts in this field show how HSA is applied to diagnosis, therapy, drugs, and treatment, with a comprehensive introduction of HSA. This volume will appeal to scientists in pharmaceutical and medical research including pharmaceutical chemists, pharmacokineticists, toxicologists, and biochemists not only in academia but also in industry. Readers can effectively acquire the most recent knowledge of applications of HSA and its impact on human health in a single volume.

All About Albumin
All About Albumin

Author: Theodore Peters Jr.

Publisher: Academic Press

Published: 1995-12-21

Total Pages: 455

ISBN-13: 0080527043

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The first of its kind, All About Albumin summarizes the chemistry, genetics, metabolism, clinical implications, and commercial aspects of albumin. It provides the most up-to-date sequences, structures, and compositions of many species, and includes more than 2000 references. - Includes up-to-date sequences, structures, and compositions of many species - Reviews the protein chemistry, genetic control, and metabolism of albumin - Covers medical and cell culture applications in vivo and in vitro, with a section on handling albumin in the laboratory - Presents the relationship of albumin to its superfamily with an updated scheme for their evolution - First complete coverage of all aspects of serum albumin in one volume, with more than 2000 references

Bio-nanoimaging
Bio-nanoimaging

Author: Vladimir N Uversky

Publisher: Academic Press

Published: 2013-11-05

Total Pages: 556

ISBN-13: 0123978211

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Bio-Nanoimaging: Protein Misfolding & Aggregation provides a unique introduction to both novel and established nanoimaging techniques for visualization and characterization of misfolded and aggregated protein species. The book is divided into three sections covering: - Nanotechnology and nanoimaging technology, including cryoelectron microscopy of beta(2)-microglobulin, studying amyloidogensis by FRET; and scanning tunneling microscopy of protein deposits - Polymorphisms of protein misfolded and aggregated species, including fibrillar polymorphism, amyloid-like protofibrils, and insulin oligomers - Polymorphisms of misfolding and aggregation processes, including multiple pathways of lysozyme aggregation, misfolded intermediate of a PDZ domain, and micelle formation by human islet amyloid polypeptide Protein misfolding and aggregation is a fast-growing frontier in molecular medicine and protein chemistry. Related disorders include cataracts, arthritis, cystic fibrosis, late-onset diabetes mellitus, and numerous neurodegenerative diseases like Alzheimer's and Parkinson's. Nanoimaging technology has proved crucial in understanding protein-misfolding pathologies and in potential drug design aimed at the inhibition or reversal of protein aggregation. Using these technologies, researchers can monitor the aggregation process, visualize protein aggregates and analyze their properties. - Provides practical examples of nanoimaging research from leading molecular biology, cell biology, protein chemistry, biotechnology, genetics, and pharmaceutical labs - Includes over 200 color images to illustrate the power of various nanoimaging technologies - Focuses on nanoimaging techniques applied to protein misfolding and aggregation in molecular medicine

Molecular Pharming
Molecular Pharming

Author: Allison R. Kermode

Publisher: John Wiley & Sons

Published: 2018-03-12

Total Pages: 496

ISBN-13: 1118801482

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A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Neuroprotection in Alzheimer's Disease
Neuroprotection in Alzheimer's Disease

Author: Illana Gozes

Publisher: Academic Press

Published: 2016-12-30

Total Pages: 344

ISBN-13: 0128037121

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Neuroprotection in Alzheimer's Disease offers a translational point-of-view from both basic and clinical standpoints, putting it on the cusp for further clinical development with its emphasis on nerve cell protection, including the accumulation of knowledge from failed clinical trials and new advances in disease management. This book brings together the latest findings, both basic, and clinical, under the same cover, making it easy for the reader to obtain a complete overview of the state-of-the-field and beyond. Alzheimer's disease is the most common form of dementia, accounting for 60 to 80 percent of dementia cases. It is a progressive brain disease that slowly destroys memory, thinking skills, and eventually, even the ability to carry out the simplest tasks. It is characterized by death of synapses coupled to death nerve cells and brain degeneration which is manifested by loss of cognitive abilities. Understanding neuroprotection in Alzheimer's disease will pave the path to better disease management and novel therapeutics. - Comprehensive reference detailing neuroprotection in Alzheimer's Disease, with details on nerve cell protection and new advances in disease management - Combines the knowledge and points-of-view of both medical doctors and basic scientists, putting the subject at the forefront for further clinical development - Edited by one of the leading researchers in Alzheimer's Disease

Comprehensive Chirality
Comprehensive Chirality

Author:

Publisher: Newnes

Published: 2012-12-31

Total Pages: 5635

ISBN-13: 0080951686

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Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Lipoproteins, Apolipoproteins, and Lipases
Lipoproteins, Apolipoproteins, and Lipases

Author:

Publisher: Academic Press

Published: 1994-03-10

Total Pages: 489

ISBN-13: 0080582184

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This volume contains eight chapters that present both new and reviewed information fundamental to a clear understanding of lipid catabolism and transport at the molecular level. Three-dimensional structures of important serum lipoproteins, apolipoproteins, and lipases, utilizing X-ray data when available, are emphasized, and an attempt is made to relate structures to function. - Amphipathic helix - Apolipoprotein E - Lipophorin - Structure of serum albumin - Lipid binding proteins - Apolipoprotein B - Low-density lipoprotein

Nano-inspired Biosensors for Protein Assay with Clinical Applications
Nano-inspired Biosensors for Protein Assay with Clinical Applications

Author: Genxi Li

Publisher: Elsevier

Published: 2018-08-29

Total Pages: 380

ISBN-13: 0128150548

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Nano-inspired Biosensors for Protein Assay with Clinical Applications introduces the latest developments in nano-inspired biosensing, helping readers understand both the fundamentals and frontiers in this rapidly advancing field. In recent decades, there has been increased interest in nano-inspired biosensors for clinical application. Proteins, e.g. antigen-antibody, tumor markers and enzymes are the most important target in disease diagnosis, and a variety of biosensing techniques and strategies have been developed for protein assay. This book brings together all the current literature on the most recent advances of protein analysis and new methodologies in designing new kinds of biosensors for clinical diagnostic use. - Provides a single source of information on the latest developments in the field of biosensors for protein analysis and clinical diagnosis - Focuses on biosensors fabricated with nanomaterials and nanotechnology - Gives detailed methodologies for designing and fabricating nano-inspired biosensors

X-PLOR
X-PLOR

Author: Axel T. Brünger

Publisher: Yale University Press

Published: 1992-01-01

Total Pages: 404

ISBN-13: 9780300054026

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X-PLOR is a highly sophisticated computer program that provides an interface between theoretical foundations and experimental data in structural biology, with specific emphasis on X-ray crystallography and nuclear magnetic resonance spectroscopy in solution of large biological macro-molecules. This manual to X-PLOR Version 3.1 presents the theoretical background, syntax, and function of the program and also provides a comprehensive list of references and sample input files with comments. It is intended primarily for researchers and students in the fields of computational chemistry, structural biology, and computational molecular biology.