Human Adenoviruses: From Villains To Vectors

Human Adenoviruses: From Villains To Vectors

Author: S Jane Flint

Publisher: World Scientific

Published: 2016-12-21

Total Pages: 416

ISBN-13: 9813109815

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Human adenoviruses play a central role in human diseases and as vectors for vaccines and gene delivery. This monograph describes the underlying principles of adenovirus molecular and structural biology, pathogenesis, antiviral measures and vector development. Much of the history of this virus and the many contributions made by its study are embedded in these discussions. Topics and questions that require further investigation are also considered.Although current virology textbooks cover topics related to adenoviruses, this book provides a comprehensive description of the virus and its interactions with the host. Students and researchers with a particular interest in adenoviruses, gene therapists, and virologists interested in viral pathogenesis will benefit from this book, which presents a unique integration of the basics with applied research in the field.


Infectious Pathology of the Respiratory Tract

Infectious Pathology of the Respiratory Tract

Author: Vsevolod Zinserling

Publisher: Springer Nature

Published: 2021-02-10

Total Pages: 259

ISBN-13: 3030663256

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This book discusses all aspects of pulmonary pathology, including different bacterial, viral, fungal, mycoplasma and protozoan pathogens, accompanied by illustrations that show macro- and histopathological changes. It also presents microbiological, epidemiological and clinical data, with a particular focus on pneumonias of different bacterial aetiologies, influenza, and other viral infections. Further, the book explores the importance of mixed infections, including those in the late stages of HIV infections and virus-bacterial pneumonias, as well as pathological changes in modern tuberculosis, lung granuloma, and respiratory tract inflammation in different age groups.


Biopharmaceuticals

Biopharmaceuticals

Author: Basanta Kumara Behera

Publisher: CRC Press

Published: 2020-12-07

Total Pages: 300

ISBN-13: 1351013130

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Biopharmaceuticals: Challenges and Opportunities This book highlights how the traditional microbial process technology has been upgraded for the production of biologic drugs how manufacturing processes have evolved to meet the global market demand with quality products under the guidelines of internally recognized regulatory bodies. It also carries information on how, armed with a deeper understanding of life-threatening diseases, biopharmaceutical companies and the life sciences industry have developed formal and informal partnerships with researchers in institutes, universities, and other R&D organizations to fulfil timely, quality production with perfect safety and security. One of the most interesting aspects of this book is the conceptual development of personalized medicine (or precision medicine) to provide the right treatment to the right patient, at the right dose at an earlier stage of development, for genetic diseases. Besides this, it also highlights the most challenging aspects of modern biopharmaceutical science, focusing on the hot topics such as design and development of biologic drugs; the use of diversified groups of host cells belonging to animals, plants, microbes, insects, and mammals; stem cell therapy and gene therapy; supply chain management of biopharmaceuticals; and the future scope of biopharmaceutical industry development. This book is the latest resource for a wide circle of scientists, students, and researchers involved in understanding and implementing the knowledge of biopharmaceuticals to develop life-saving biologic drugs and to bring awareness to the development of personalized treatment that can potentially offer patients a faster diagnosis, fewer side effects, and better outcomes. Features: Explains how the traditional cell culture methodology has been changed to a fully continuous or partially continuous process Explains how to design and fabricate living organs of body by 3D bioprinting technology Focuses on how a biopharmaceutical company deals with various problems of regulatory bodies and develops innovative biologic drugs Narrates in detail the updated information on stem cell therapy and gene therapy Explains the development strategies and clinical significance of biosimilars and biobetters Highlights the supply chain management of biopharmaceuticals


Diseases of Poultry

Diseases of Poultry

Author:

Publisher: John Wiley & Sons

Published: 2019-11-19

Total Pages: 1488

ISBN-13: 1119371171

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The most complete and definitive reference to all aspects of poultry diseases, Diseases of Poultry, Fourteenth Edition has been fully revised and updated to offer a comprehensive survey of current knowledge. Updates the definitive reference of poultry health and disease Provides more clinically relevant information on management of specific diseases, contributed by clinical poultry veterinarians Offers information on disease control in organic and antibiotic-free production Presents more concise, streamlined chapters for ease of use Incorporates advances in the field, from new diagnostic tools and information to changes brought about by the increasing globalization and the re-emergence of zoonotic pathogens


The Vaccine Book

The Vaccine Book

Author: Barry R. Bloom

Publisher: Academic Press

Published: 2016-06-23

Total Pages: 666

ISBN-13: 012805400X

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The Vaccine Book, Second Edition provides comprehensive information on the current and future state of vaccines. It reveals the scientific opportunities and potential impact of vaccines, including economic and ethical challenges, problems encountered when producing vaccines, how clinical vaccine trials are designed, and how to introduce vaccines into widespread use. Although vaccines are now available for many diseases, there are still challenges ahead for major diseases, such as AIDS, tuberculosis, and malaria. This book is designed for students, researchers, public health officials, and all others interested in increasing their understanding of vaccines. It answers common questions regarding the use of vaccines in the context of a rapidly expanding anti-vaccine environment. This new edition is completely updated and revised with new and unique topics, including new vaccines, problems of declining immunization rates, trust in vaccines, the vaccine hesitancy, and the social value of vaccines for the community vs. the individual child's risk. - Provides insights into diseases that could be prevented, along with the challenges facing research scientists in the world of vaccines - Gives new ideas about future vaccines and concepts - Introduces new vaccines and concepts - Gives ideas about challenges facing public and private industrial investors in the vaccine area - Discusses the problem of declining immunization rates and vaccine hesitancy


Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)

Author: Daniel Scherman

Publisher: World Scientific

Published: 2019-07-16

Total Pages: 634

ISBN-13: 1786346893

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This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.


The Adenoviruses

The Adenoviruses

Author: Harold S. Ginsberg

Publisher: Springer Science & Business Media

Published: 2013-03-08

Total Pages: 620

ISBN-13: 1468479350

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The discovery of adenoviruses naturally induced a new interest in viruses of the human upper respiratory tract since previously unknown viruses infecting this portion of the human body had not been identified in 20 years, and their unique characteristics stimulated investigations into the biochemical events essential for replication of animal viruses. Indeed, the field of molecular virology has evolved during the period since their dis covery, and adenoviruses have played a major role in this development. The exciting discoveries made with adenoviruses have had such a pro found effect on knowledge in basic virology, molecular biology, viral ge netics, human and animal infections, and cell transformation that this seemed a propitious time to have some of the major contributors review this field. This volume pays tribute to the late Wallace Rowe, Robert Huebner, and Maurice Hilleman whose initial discoveries of adenoviruses have tremendously enriched virology. Harold S. Ginsberg vii Contents Chapter 1 An Overview 1 Harold S. Ginsberg Chapter 2 The Architecture of Adenoviruses M. V. Nermut I. Introduction ................................... . 5 II. Chemical and Physical Properties ................... . 6 III. Virus Capsid: Composition and Organization .......... . 7 A. Hexon ..................................... . 10 B. Penton .................................... . 12 C. Other Virus Polypeptides Associated with the Capsid 13 D. Organization of the Capsid ..................... . 14 IV. Virus Core .................................... . 15 A. Evidence for the Core Shell ..................... . 17 B. Organization of the DNA-Protein Complex (Nucleoc- sid) ....................................... . 18 C. Tentative Model of the Adenovirus Nucleocapsid ... . 22 V. Model of the Adenovirion ......................... . 29 32 References .......................................... .


Pathology of the Lungs E-Book

Pathology of the Lungs E-Book

Author: Bryan Corrin

Publisher: Elsevier Health Sciences

Published: 2011-02-25

Total Pages: 785

ISBN-13: 0702046221

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With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation


Viruses and Man: A History of Interactions

Viruses and Man: A History of Interactions

Author: Milton W. Taylor

Publisher: Springer

Published: 2014-07-21

Total Pages: 433

ISBN-13: 3319077589

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Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.