Dieser Werk behandelt umfassend und aktuell Stoffwechselveränderungen beim Menschen, die mit Wirt-Erreger-Beziehungen in Zusammenhang stehen. Teil 1 beschreibt die Anpassung pathogener Mikroben an Stoffwechselvorgänge. Teil 2 zeigt Wege für die Entwicklung neuartiger Antibiotika.
Infectious diseases have existed longer than us, as long as us, or are relatively newer than us. It may be the case that a disease has existed for many, many years but has only recently begun affecting humans. At the turn of the century the number of deaths caused by infections in the United States had been falling steadily but since the '80s has seen an increase. In the past 30 years alone 37 new pathogens have been identified as human disease threats and 12% of known human pathogens have been classified as either emerging or remerging. Whatever the story, there is currently a "war" on infectious diseases. This war is simply the systematic search for the microbial "cause" of each disease, followed by the development of antimicrobial therapies. The "war" on infectious diseases, however, must be revisited in order to develop a more realistic and detailed picture of the dynamic interactions among and between host organisms and their diverse populations of microbes. Only a fraction of these microbes are pathogens. Thus, in order to explore the crafting of a new metaphor for host-microbe relationships, and to consider how such a new perspective might inform and prioritize biomedical research, the Forum on Microbial Threats of the Institute of Medicine (IOM) convened the workshop, Ending the War Metaphor: The Changing Agenda for Unraveling the Host-Microbe Relationship on March 16-17, 2005. Workshop participants examined knowledge and approaches to learning about the bacterial inhabitants of the human gut, the best known host-microbe system, as well as findings from studies of microbial communities associated with other mammals, fish, plants, soil, and insects. The perspective adopted by this workshop is one that recognizes the breadth and diversity of host-microbe relationships beyond those relative few that result in overt disease. Included in this summary are the reports and papers of individuals participating in the Forum as well as the views of the editors.
Plants and microbes interact in a complex relationship that can have both harmful and beneficial impacts on both plant and microbial communities. Effectors, secreted microbial molecules that alter plant processes and facilitate colonization, are central to understanding the complicated interplay between plants and microbes. Effectors in Plant-Microbe Interactions unlocks the molecular basis of this important class of microbial molecules and describes their diverse and complex interactions with host plants. Effectors in Plant Microbe Interactions is divided into five sections that take stock of the current knowledge on effectors of plant-associated organisms. Coverage ranges from the impact of bacterial, fungal and oomycete effectors on plant immunity and high-throughput genomic analysis of effectors to the function and trafficking of these microbial molecules. The final section looks at effectors secreted by other eukaryotic microbes that are the focus of current and future research efforts. Written by leading international experts in plant-microbe interactions, Effectors in Plant Microbe Interactions, will be an essential volume for plant biologists, microbiologists, pathologists, and geneticists.
The use of microbial plant protection products is growing and their importance will strongly increase due to political and public pressure. World population is growing and the amount of food needed by 2050 will be double of what is produced now whereas the area of agricultural land is decreasing. We must increase crop yield in a sustainable way. Chemical plant growth promoters must be replaced by microbiological products. Also here, the use of microbial products is growing and their importance will strongly increase. A growing area of agricultural land is salinated. Global warming will increase this process. Plants growth is inhibited by salt or even made impossible and farmers tend to disuse the most salinated lands. Microbes have been very successfully used to alleviate salt stress of plants. Chemical pollution of land can make plant growth difficult and crops grown are often polluted and not suitable for consumption. Microbes have been used to degrade these chemical pollutants.
This volume of Methods in Cell Biology is the 3e, and provides comprehensive compendia of laboratory protocols and reviews covering all the new methods developed since 2004. This new volume on Disease Models and Chemical Screens, covers two rapidly emerging and compelling applications of the zebrafish. - Details state-of-the art zebrafish protocols, delineating critical steps in the procedures as well as potential pitfalls - This volume concentrates on Disease Models and Chemical Screens
Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.
This book, divided into 13 chapters, explores recent discoveries in the area of molecular plant-microbe interactions. It focuses mainly on the mechanisms controlling plant disease resistance and the cross talk among the signalling pathways involved, and the strategies used by fungi and viruses to suppress these defences. Two chapters deal with the role of symbionts (such as the symbiotic actinobacteria and vesicular arbuscular mycorrhizal fungi) during their interactions with plants.
Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook, devoted to systems biology, describes how to model networks, how to determine their properties, and how to relate these to phenotypic functions. The prerequisites are some knowledge of linear algebra and biochemistry. Though the links between the mathematical ideas and biological processes are made clear, the book reflects the irreversible trend of increasing mathematical content in biology education. Therefore to assist both teacher and student, in an associated website Palsson provides problem sets, projects and Powerpoint slides, and keeps the presentation in the book concrete with illustrative material and experimental results.
All parts of our body having communication with the external environment such as the skin, vagina, the respiratory tract or the gastrointestinal tract are colonized by a specific microbial community. The colon is by far the most densely populated organ in the human body. The pool of microbes inhabiting our body is known as “microbiota” and their collective genomes as “microbiome”. These microbial ecosystems regulate important functions of the host, and their functionality and the balance among the diverse microbial populations is essential for the maintenance of a “healthy status”. The impressive development in recent years of next generation sequencing (NGS) methods have made possible to determine the gut microbiome composition. This, together with the application of other high throughput omic techniques and the use of gnotobiotic animals has greatly improved our knowledge of the microbiota acting as a whole. In spite of this, most members of the human microbiota are largely unknown and remain still uncultured. The final functionality of the microbiota is depending not only on nutrient availability and environmental conditions, but also on the interrelationships that the microorganisms inhabiting the same ecological niche are able to establish with their partners, or with their potential competitors. Therefore, in such a competitive environment microorganisms have had to develop strategies allowing them to cope, adapt, or cooperate with their neighbors, which may imply notable changes at metabolic, physiological and genetic level. The main aim of this Research Topic was to contribute to better understanding complex interactions among microorganisms residing in human microbial habitats.