High Calorie Diet and the Human Brain
High Calorie Diet and the Human Brain

Author: Akhlaq A. Farooqui

Publisher: Springer

Published: 2015-03-25

Total Pages: 325

ISBN-13: 3319152548

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The purpose of this monograph is to present readers with a comprehensive and cutting edge description of neurochemical effects of diet (beneficial and harmful effects) in normal human brain and to discuss how present day diet promotes pathogenesis of stroke, AD, PD, and depression in a manner that is useful not only to students and teachers but also to researchers, dietitians, nutritionists and physicians. A diet in sufficient amount and appropriate macronutrients is essential for optimal health of human body tissues. In brain, over-nutrition, particularly with high-calorie diet, not only alters cellular homeostasis, but also results in changes in the intensity of signal transduction processes in reward centers of the brain resulting in food addiction. Over-nutrition produces detrimental effects on human health in general and brain health in particular because it chronically increases the systemic and brain inflammation and oxidative stress along with induction of insulin resistance and leptin resistance in the brain as well as visceral organs. Onset of chronic inflammation and oxidative stress not only leads to obesity and heart disease, but also promotes type II diabetes and metabolic syndrome, which are risk factors for both acute neural trauma (stroke) and chronic age-related neurodegenerative and neuropsychological disorders, such as Alzheimer disease (AD), Parkinson disease (PD) and depression.

Fat Detection
Fat Detection

Author: Jean-Pierre Montmayeur

Publisher: CRC Press

Published: 2009-09-14

Total Pages: 646

ISBN-13: 1420067761

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Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se

The Hungry Brain
The Hungry Brain

Author: Stephan J. Guyenet, Ph.D.

Publisher: Flatiron Books

Published: 2017-02-07

Total Pages: 304

ISBN-13: 1250081238

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A Publishers Weekly Best Book of the Year From an obesity and neuroscience researcher with a knack for engaging, humorous storytelling, The Hungry Brain uses cutting-edge science to answer the questions: why do we overeat, and what can we do about it? No one wants to overeat. And certainly no one wants to overeat for years, become overweight, and end up with a high risk of diabetes or heart disease--yet two thirds of Americans do precisely that. Even though we know better, we often eat too much. Why does our behavior betray our own intentions to be lean and healthy? The problem, argues obesity and neuroscience researcher Stephan J. Guyenet, is not necessarily a lack of willpower or an incorrect understanding of what to eat. Rather, our appetites and food choices are led astray by ancient, instinctive brain circuits that play by the rules of a survival game that no longer exists. And these circuits don’t care about how you look in a bathing suit next summer. To make the case, The Hungry Brain takes readers on an eye-opening journey through cutting-edge neuroscience that has never before been available to a general audience. The Hungry Brain delivers profound insights into why the brain undermines our weight goals and transforms these insights into practical guidelines for eating well and staying slim. Along the way, it explores how the human brain works, revealing how this mysterious organ makes us who we are.

Food Components to Enhance Performance
Food Components to Enhance Performance

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1994-02-01

Total Pages: 560

ISBN-13: 030905088X

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The physiological or psychological stresses that employees bring to their workplace affect not only their own performance but that of their co-workers and others. These stresses are often compounded by those of the job itself. Medical personnel, firefighters, police, and military personnel in combat settingsâ€"among othersâ€"experience highly unpredictable timing and types of stressors. This book reviews and comments on the performance-enhancing potential of specific food components. It reflects the views of military and non-military scientists from such fields as neuroscience, nutrition, physiology, various medical specialties, and performance psychology on the most up-to-date research available on physical and mental performance enhancement in stressful conditions. Although placed within the context of military tasks, the volume will have wide-reaching implications for individuals in any job setting.

Survival of the Fattest
Survival of the Fattest

Author: Stephen C. Cunnane

Publisher: World Scientific

Published: 2005

Total Pages: 363

ISBN-13: 9812567704

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How did humans evolve larger and more sophisticated brains? In general, evolution depends on a special combination of circumstances: part genetics, part time, and part environment. In the case of human brain evolution, the main environmental influence was adaptation to a OCyshore-basedOCO diet, which provided the worldOCOs richest source of nutrition, as well as a sedentary lifestyle that promoted fat deposition. Such a diet included shellfish, fish, marsh plants, frogs, birdOCOs eggs, etc. Humans and, and more importantly, hominid babies started to get fat, a crucial distinction that led to the development of larger brains and to the evolution of modern humans. A larger brain is expensive to maintain and this increasing demand for energy results in, succinctly, survival of the fattest."

Brain, Nutrition and Metabolism
Brain, Nutrition and Metabolism

Author: Ruth I. Versteeg

Publisher:

Published: 2017

Total Pages: 233

ISBN-13:

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This thesis describes studies on the effects of obesity, weight loss and meal timing on the human brain and glucose metabolism. We investigated effects of meal timing during a hypocaloric diet and weight loss on brain serotonin transporters (SERT) and dopamine transporters (DAT), neuronal activity patterns and metabolism. In addition, we studied the effect of bright light conditions on glucose and lipid metabolism in lean and obese subjects with type 2 diabetes (T2D). First, we show a trend towards lower hypothalamic SERT binding in obese compared to lean controls and a reduced SERT binding in the diencephalon in obese insulin resistant compared to equally obese insulin sensitive and lean subjects. Second, we show that subjects who consumed most of the calories in the morning during a hypocaloric diet, increased striatal DAT binding and reduced neuronal activation in response to high calorie food pictures in the caudate nucleus, while consuming most of the calories in the evening reduced striatal DAT binding and increased neuronal activation in response to high calorie food pictures in the caudate nucleus. Metabolism and intrahepatic triglyceride content improved after weight loss but without a differential effect of meal timing. Finally, we found that acute exposure to bright light affects glucose metabolism in obese subjects with T2D and lipid metabolism in both, patients with T2D and healthy controls. Taken together, this thesis provides data supporting a clinically relevant interaction between meal timing, body weight loss and the brain, and between light exposure and metabolism.

The Role of Protein and Amino Acids in Sustaining and Enhancing Performance
The Role of Protein and Amino Acids in Sustaining and Enhancing Performance

Author: Institute of Medicine

Publisher: National Academies Press

Published: 1999-09-15

Total Pages: 448

ISBN-13: 0309172810

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It is a commonly held belief that athletes, particularly body builders, have greater requirements for dietary protein than sedentary individuals. However, the evidence in support of this contention is controversial. This book is the latest in a series of publications designed to inform both civilian and military scientists and personnel about issues related to nutrition and military service. Among the many other stressors they experience, soldiers face unique nutritional demands during combat. Of particular concern is the role that dietary protein might play in controlling muscle mass and strength, response to injury and infection, and cognitive performance. The first part of the book contains the committee's summary of the workshop, responses to the Army's questions, conclusions, and recommendations. The remainder of the book contains papers contributed by speakers at the workshop on such topics as, the effects of aging and hormones on regulation of muscle mass and function, alterations in protein metabolism due to the stress of injury or infection, the role of individual amino acids, the components of proteins, as neurotransmitters, hormones, and modulators of various physiological processes, and the efficacy and safety considerations associated with dietary supplements aimed at enhancing performance.

The Intermittent Fasting Revolution
The Intermittent Fasting Revolution

Author: Mark P. Mattson

Publisher: MIT Press

Published: 2023-04-04

Total Pages: 249

ISBN-13: 0262545985

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How intermittent fasting can enhance resilience, improve mental and physical performance, and protect against aging and disease. Most of us eat three meals a day with a smattering of snacks because we think that’s the normal, healthy way to eat. This book shows why that’s not the case. The human body and brain evolved to function well in environments where food could be obtained only intermittently. When we look at the eating patterns of our distant ancestors, we can see that an intermittent fasting eating pattern is normal—and eating three meals a day is not. In The Intermittent Fasting Revolution, prominent neuroscientist Mark Mattson shows that intermittent fasting is not only normal but also good for us; it can enhance our ability to cope with stress by making cells more resilient. It also improves mental and physical performance and protects against aging and disease. Intermittent fasting is not the latest fad diet; it doesn’t dictate food choice or quantity. It doesn’t make money for the pharmaceutical, processed food, or health care industries. Intermittent fasting is an eating pattern that includes frequent periods of time with little or negligible amounts of food. It is often accompanied by weight loss, but, Mattson says, studies show that its remarkable beneficial effects cannot be accounted for by weight loss alone. Mattson—whose pioneering research uncovered the ways that the brain responds to fasting and exercise—explains how thriving while fasting became an evolutionary adaptation. He describes the specific ways that intermittent fasting slows aging; reduces the risk of diseases, including obesity, Alzheimer’s, and diabetes; and improves both brain and body performance. He also offers practical advice on adopting an intermittent fasting eating pattern as well as information for parents and physicians.

Food Addiction, Obesity, and Disorders of Overeating
Food Addiction, Obesity, and Disorders of Overeating

Author: Claire E. Wilcox

Publisher: Springer Nature

Published: 2021-09-30

Total Pages: 224

ISBN-13: 3030830780

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This book is written for providers of broad training backgrounds, and aims to help those who care for people with EDs, overweight and obesity provide evidence-based care. The goal of the book is to provide these providers with a straightforward resource summarizing the current standard of care. However, it goes further by also introducing the concept of food addiction (FA) as a model to understand some forms of overeating. This book discusses the pros and cons of embracing FA and reviews the evidence for and against the validity and utility of FA. By doing so, the chapters convey a “middle ground” approach to help people with obesity, BED, and bulimia nervosa plus FA symptomatology who also want to lose weight. The text discusses FA by reviewing several of the main ongoing controversies associated with the construct. It reviews both the clinical and neuroscientific evidence that some individuals’ eating behavior mirrors that seen in substance use disorders (SUD), such as how their relationship with food appears to be “addictive”. Chapters also discuss how many of the mechanisms known to underlie SUDs appear to drive overeating in animal models and humans. Finally, the text argues that the similarities between the brain mechanisms of addictive disorders and overeating behavior has the potential to open up new avenues for current treatment and treatment development. Food Addiction, Obesity and Disorders of Overeating: An Evidence-Based Assessment and Clinical Guide is suited for both medical and mental health practitioners, including physicians in primary care or psychiatry, nurses, psychologists, social workers, medical students and medical residents. It could also be utilized by researchers in obesity and ED fields, stimulating ideas for future research and study design.

Molecular Mechanisms of Dementia
Molecular Mechanisms of Dementia

Author: Akhlaq A. Farooqui

Publisher: Academic Press

Published: 2019-04-15

Total Pages: 386

ISBN-13: 0128167319

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Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia