Neither minimizing the difficulty of the choices that modern genetics has created for us nor fearing them, Cowan argues that we can improve the quality of our own lives and the lives of our children by using the modern science and technology of genetic screening responsibly.
As a speaker on women's health and the CEO of an internationally recognized anti-aging center of excellence, Genie James knows all too well that many women are spending too much money, time, and worry battling thickening waists, wrinkles, memory loss, and low libido. Besieged by a mountain of anti-aging information and products, James found too much of it was marketing hype written by researchers with financial ties to companies touting the fountain of youth. In this eye-opening read, James doesn't just tell women how to slow the aging process; she offers a revolutionary approach to change the aging process, securing a much healthier, happier, and more vibrant future. Medical miracles really do have the potential to reduce our risk of chronic disease while positively impacting long-term health, sexuality, and longevity, and there are things you can do to override your genes to age slower, happier, and better. But, shift happens, as they say, and there are some things you can't change, and some things that are downright dangerous. James shares the good, the bad, and the ugly. With refreshing candor, case studies, and insights about her personal struggles with gravity and greying, James sifts through the latest science to help women devise a personalized plan to overhaul key areas of health, from hormones, heart and breast health, to weight loss, memory, moods, and their sex lives.
2019 PEN/E.O. Wilson Literary Science Writing Award Finalist "Science book of the year"—The Guardian One of New York Times 100 Notable Books for 2018 One of Publishers Weekly's Top Ten Books of 2018 One of Kirkus's Best Books of 2018 One of Mental Floss's Best Books of 2018 One of Science Friday's Best Science Books of 2018 “Extraordinary”—New York Times Book Review "Magisterial"—The Atlantic "Engrossing"—Wired "Leading contender as the most outstanding nonfiction work of the year"—Minneapolis Star-Tribune Celebrated New York Times columnist and science writer Carl Zimmer presents a profoundly original perspective on what we pass along from generation to generation. Charles Darwin played a crucial part in turning heredity into a scientific question, and yet he failed spectacularly to answer it. The birth of genetics in the early 1900s seemed to do precisely that. Gradually, people translated their old notions about heredity into a language of genes. As the technology for studying genes became cheaper, millions of people ordered genetic tests to link themselves to missing parents, to distant ancestors, to ethnic identities... But, Zimmer writes, “Each of us carries an amalgam of fragments of DNA, stitched together from some of our many ancestors. Each piece has its own ancestry, traveling a different path back through human history. A particular fragment may sometimes be cause for worry, but most of our DNA influences who we are—our appearance, our height, our penchants—in inconceivably subtle ways.” Heredity isn’t just about genes that pass from parent to child. Heredity continues within our own bodies, as a single cell gives rise to trillions of cells that make up our bodies. We say we inherit genes from our ancestors—using a word that once referred to kingdoms and estates—but we inherit other things that matter as much or more to our lives, from microbes to technologies we use to make life more comfortable. We need a new definition of what heredity is and, through Carl Zimmer’s lucid exposition and storytelling, this resounding tour de force delivers it. Weaving historical and current scientific research, his own experience with his two daughters, and the kind of original reporting expected of one of the world’s best science journalists, Zimmer ultimately unpacks urgent bioethical quandaries arising from new biomedical technologies, but also long-standing presumptions about who we really are and what we can pass on to future generations.
The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).
Bonduriansky and Day challenge the premise that genes alone mediate the transmission of biological information across generations and provide the raw material for natural selection. They explore the latest research showing that what happens during our lifetimes--and even our parents' and grandparents' lifetimes--can influence the features of our descendants. Based on this evidence, Bonduriansky and Day develop an extended concept of heredity that upends ideas about how traits can and cannot be transmitted across generations, opening the door to a new understanding of inheritance, evolution, and even human health. --Adapted from publisher description.
If not for the work of his half cousin Francis Galton, Charles Darwin's evolutionary theory might have met a somewhat different fate. In particular, with no direct evidence of natural selection and no convincing theory of heredity to explain it, Darwin needed a mathematical explanation of variability and heredity. Galton's work in biometry—the application of statistical methods to the biological sciences—laid the foundations for precisely that. This book offers readers a compelling portrait of Galton as the "father of biometry," tracing the development of his ideas and his accomplishments, and placing them in their scientific context. Though Michael Bulmer introduces readers to the curious facts of Galton's life—as an explorer, as a polymath and member of the Victorian intellectual aristocracy, and as a proponent of eugenics—his chief concern is with Galton's pioneering studies of heredity, in the course of which he invented the statistical tools of regression and correlation. Bulmer describes Galton's early ambitions and experiments—his investigations of problems of evolutionary importance (such as the evolution of gregariousness and the function of sex), and his movement from the development of a physiological theory to a purely statistical theory of heredity, based on the properties of the normal distribution. This work, culminating in the law of ancestral heredity, also put Galton at the heart of the bitter conflict between the "ancestrians" and the "Mendelians" after the rediscovery of Mendelism in 1900. A graceful writer and an expert biometrician, Bulmer details the eventual triumph of biometrical methods in the history of quantitative genetics based on Mendelian principles, which underpins our understanding of evolution today.
How tiny variations in our personal DNA can determine how we look, how we behave, how we get sick, and how we get well. News stories report almost daily on the remarkable progress scientists are making in unraveling the genetic basis of disease and behavior. Meanwhile, new technologies are rapidly reducing the cost of reading someone's personal DNA (all six billion letters of it). Within the next ten years, hospitals may present parents with their newborn's complete DNA code along with her footprints and APGAR score. In Genetic Twists of Fate, distinguished geneticists Stanley Fields and Mark Johnston help us make sense of the genetic revolution that is upon us. Fields and Johnston tell real life stories that hinge on the inheritance of one tiny change rather than another in an individual's DNA: a mother wrongly accused of poisoning her young son when the true killer was a genetic disorder; the screen siren who could no longer remember her lines because of Alzheimer's disease; and the president who was treated with rat poison to prevent another heart attack. In an engaging and accessible style, Fields and Johnston explain what our personal DNA code is, how a few differences in its long list of DNA letters makes each of us unique, and how that code influences our appearance, our behavior, and our risk for such common diseases as diabetes or cancer.
Recent discoveries in molecular biology have shown that genes governing life processes in widely different organisms from yeast to humans are essentially alike. That is the underlying theme of this book as it looks for meaning in the natural world while exploring complex questions in molecular genetics. Ackerman, a former staff writer for National Geographic and a nature author (Notes from the Shore), weaves her own personal experiences into this popular account of the natural history of heredity. (When she is pregnant with her first child, Ackerman worries that the baby will inherit the gene that caused the retardation of her younger sister.) Topics range from development and sex determination to biological clocks and cell death, and more.